22/09/2023
Podosomes in lung fibroblasts stimulate extracellular matrix invasion and pulmonary fibrosis, suggesting pharmacologic targeting of podosome formation or organization as a very promising therapeutic option. [PubMed]
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31/08/2023
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. [PubMed]
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25/03/2023
Exploiting the vast transcriptomic information stored at Fibromine, all publicly available omics datasets on Idiopathic Pulmonary Fibrosis (IPF) were compared, and deregulated genes in most datasets were prioritized via machine learning, resulting in a list of genes with highly predictive statistical power. [PubMed]
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05/03/2023
In our effort to discover new Autotaxin (ATX) inhibitors we have previously identified various hits [Pubmed] that led to six Industrial Property Organization (IPO) patents GR1010099, GR1010098, GR1010104, GR1010103, GR1010097, GR1010096. This effort was followed by a hit-to-lead potency optimization process employing Structure-Activity Relationship studies culminating in the finding of two new ATX inhibitors (with an active IPO patent GR1010268 and a Patent Cooperation Treaty (PCT) application WO 2022/003377 A1) now being at the stage of lead optimization [Pubmed].
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05/07/2022
IMultiplex ELISA querying the phosphorylation of 27 phosphoproteins/signaling hubs and the secretion of 32 mediators (cytokines, chemokines and growth factors) revealed that Lysophosphatidic Acid (LPA) is a proinflammatory stimulus of renal tubular epithelial cells. Moreover, LPA responses were compared with other 175 biological stimuli, indicating that LPA clusters with other pro-inflammatory growth factors (e.g. TNF, IL1a).
[Pubmed].
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19/02/2022
Enabling the study of microbiomics locally, a 16S rRNA deep sequencing pipeline has been created and was used to examine and compare the microbial communities of the gut, liver, and lung of obese and lean mice. [PubMed]
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25/11/2021
Fibromine, a new database and data mining tool for target discovery in pulmonary fibrosis has been created to explore the numerous related publicly available datasets. [PubMed]
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25/10/2021
Fleming researchers and clinical collaborators have reported increased serum Autotaxin Levels in Severe COVID-19 patients, correlating with serum IL-6 and endothelial dysfunction biomarkers levels, as well as with impaired functions of dendritic cells. [PubMed]
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18/01/2021
A central role for TPL2 in the regulation of fibrotic responses in the lung. [PubMed]
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27/11/2019
A new Frontiers E-book on “Pulmonary Fibrosis”, guest-edited by Fleming Researchers and distinguished leading experts, was recently published.
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09/05/2018
Expanding previous work on the role of autotaxin in chronic inflammatory disorders that has provided the scientific basis for phase IIb clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a role for this secreted lysophospholipase D in the pathogenesis of lung cancer [PubMed].
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29/01/2018
In a collaborative study published in Nat Med, a Fleming Marie Curie Fellow revealed that aerosolized delivery of active Thyroid Hormone (TH) resolved pulmonary fibrosis in two mouse models through a mechanism that involved improvement of mitochondrial biogenesis and mitophagy in alveolar type II epithelial cells. [PubMed].
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19/12/2016
Expanding previous work on the role of autotaxin in chronic inflammatory disorders that have led to phase II clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a novel, major role for this secreted lysophospholipase D in the pathogenesis of hepatitis and hepatocellular carcinoma. [PubMed].
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06/07/2012
Fleming researchers have revealed a major role for Autotaxin (ATX, ENPP2) and its bioactive lipid product lysophosphatidic acid (LPA) in the pathogenesis of rheumatoid arthritis [Pubmed1] and pulmonary fibrosis [Pubmed2]. Their work establishes the ATX/LPA axis as a novel player in chronic inflammatory disorders [Pubmed3] and as a promising therapeutic target. See also related highlights at Nat. Rev. Rheum, F1000, AJRCMB and TIS.
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16/01/2010
Fleming’s researchers have discovered that embryonic expression of Autotaxin, a secreted lysophospholipase D generating lysophosphatidic acid, is necessary for vascular branching morphogenesis and neural tube closure. [PubMed].
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12/02/2009
Pulmonary translational research at Fleming: Researchers at the institute of immunology in collaboration with various University hospitals have discovered an important role for gelsolin, an actin-binding protein, in lung pathophysiology [Pubmed].
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01/08/2008
Inauguration of BSRC Fleming’s Expression Profiling Unit. The Unit is equipped with the most advanced technology on microarray experimentation and data analysis. The BSRC Al. Fleming’s Expression Profiling Unit provides expression profiling services to academic and research centers as well as the private sector.
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22/02/2008
Researchers at the Institute for Immunology, utilizing comparative expression profiling, have discovered new genes and pathways involved in the pathophysiology of pulmonary fibrosis. Among them and through the utilization of tissue microarrays, HIF-1a was shown to have an early primary role in disease pathogenesis. [Pubmed].
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22/11/2007
The MUGEN Mouse Database (MMdb) is a database of murine models of immune processes and immunological diseases. MMdb was developed in the context of MUGEN network of Excellence (MUGEN NoE) and serves as a use-case example of database integration and interoperability, in the context of CASIMIR, a co-ordination action on mouse resource integration [Pubmed].
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27/02/2007
BSRC "Alexander Fleming" has recently published at PLoS One new work suggesting the use of soluble TNF inhibitors in the treatment of Idiopathic Pulmonary Fibrosis [Pubmed][F1000].
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