The scientists at BSRC “Alexander Fleming” perform cutting-edge research, aiming to understand molecular mechanisms of complex biological processes in health and disease. We are also committed to contribute to innovation in medicine, by developing novel therapeutic and diagnostic methods, focusing on immunity and inflammation, cancer, and neurodegenerative diseases. To keep our focus on top-notch research, we recruit at all levels with excellence as the sole criterion and we support our researchers by providing state-of-the science infrastructures and a pleasant working environment. FLEMING is a non-profit organization operating under the auspices of the Greek General Secretariat for Research & Technology and is supported by the Greek government and by national, European and international grants.
Highlights
Koliaraki et al. from the Kollias and Koliaraki labs demonstrate that innate sensing through mesenchymal TLR4/MyD88 signals promotes spontaneous intestinal tumorigenesis. Genetic deletion of TLR4 or MyD88 in IMCs led to altered molecular profiles and reduction of intestinal tumors in the APCmin model. [Pubmed]
Christodoulou-Vafeiadou and Ioakeimidis et al. in the Kontoyiannis lab showed that the ubiquitous RNA binding protein HuR has divergent roles in intestinal epithelial cells and myeloid-derived immune compartment in various models of intestinal inflammation and cancer. [PubMed]
Semelidou et al from the Skoulakis lab demonstrated that distinct neuronal circuits mediate olfactory habituation latency and induction and proposed a novel role for the Lateral Horn, a neuropil innately encoding response valence to odor stimuli, in this process. [Pubmed]
Greece joins the European Research Infrastructure ELIXIR as a full Member. As an ELIXIR Member, the Greek Node of ELIXIR – coordinated by BSRC Fleming - and the Greek bioinformatics community is now able to fully integrate into ELIXIR activities and collaborate with other ELIXIR Nodes. Press release.
NEWS AND EVENTS
11/01/2019
EMBO Workshop "Mesenchymal cells in inflammation, immunity and cancer" | 19-23 May 2019 | Abstract submission and registration is NOW OPEN with a deadline for February 11th.
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B.S.R.C. "Alexander Fleming"
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