The scientists at BSRC “Alexander Fleming” perform cutting-edge research, aiming to understand molecular mechanisms of complex biological processes in health and disease. We are also committed to contribute to innovation in medicine, by developing novel therapeutic and diagnostic methods, focusing on immunity and inflammation, cancer, and neurodegenerative diseases. To keep our focus on top-notch research, we recruit at all levels with excellence as the sole criterion and we support our researchers by providing state-of-the science infrastructures and a pleasant working environment. FLEMING is a non-profit organization operating under the auspices of the Greek General Secretariat for Research & Technology and is supported by the Greek government and by national, European and international grants.
Recent work by Fleming researchers identifies a Wnt-regulated long non-coding RNA that controls intestinal stem cell fate and carcinogenesis. Pubmed
Recent work by Fleming researchers demonstrates that the histone methyltransferase Smyd3 is required for the development of experimentally induced liver and colon cancer in mice. Pubmed
The study by Fleming researchers highlighted in December 2015 (Koliaraki et al., J. Exp. Med. 2015) is featured in a “News & Views” article in Nature. The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.