Immunity & Inflammation
Neuroscience
Cancer Biology
RNA Biology & Epigenetics
Bioinformatics & Computational Biology
The scientists at BSRC “Alexander Fleming” perform cutting-edge research, aiming to understand molecular mechanisms of complex biological processes in health and disease. We are also committed to contribute to innovation in medicine, by developing novel therapeutic and diagnostic methods, focusing on immunity and inflammation, cancer, and neurodegenerative diseases. To keep our focus on top-notch research, we recruit at all levels with excellence as the sole criterion and we support our researchers by providing state-of-the science infrastructures and a pleasant working environment. FLEMING is a non-profit organization operating under the auspices of the Greek General Secretariat for Research & Technology and is supported by the Greek government and by national, European and international grants.
Highlights
A new Frontiers E-book on “Pulmonary Fibrosis”, guest-edited by Fleming Researchers and distinguished leading experts, was recently published. The E-book comprises of 13 peer-reviewed articles published in the corresponding research topic, in the section of Pulmonary Medicine, Frontiers in Medicine [Frontiers].
Fleming researchers, in collaboration with GlaxoSmithKline and the London School of Hygiene and Tropical Medicine, developed a novel series of fast-kill agents against malaria. Chemoproteomic analysis also showed that the mechanism through which this fast-kill effect is exhibited is the inhibition of serine/arginine protein kinase 2 (SRPK2), thus rendering this target a tractable approach for developing antimalarial compounds with extremely fast-killing properties. [Pubmed]
Glentis et al., from the Dimas lab, uncover genetic risk variants for hereditary breast cancer in the first exome sequencing study to be conducted in the Greek population. The authors carried out exome sequencing on BSRC Alexander Fleming’s in-house NGS platform, in patients with hereditary breast cancer of unknown genetic aetiology and in their informative relatives. [Pubmed]
Custom bioinformatics analysis performed by Dr. Martin Reczko contributed to a new collaborative study that introduces a platform for bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation, associated with a wide range of human disorders, including Alzheimer’s and Parkinson’s disease. [Science Advances]
NEWS AND EVENTS
20/12/2019
Seminar 20/12/2019, 14.00. "At the crossroads of aging, metabolism and cognition", Lida Katsimbardi, PhD , Perception and Memory Lab, Neuroscience Dept., Institut Pasteur, Paris, France.
PUBLICATIONS
Visit BSRC Fleming's scientific Publications web page
FUNDING
Visit BSRC Fleming's funding web page
B.S.R.C. "Alexander Fleming"
34 Fleming Street, 16672 Vari, Greece
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