Through our research we aim to understand how medically relevant, complex traits are shaped in humans. We seek to characterize the genetic architecture shaping disease risk, as well as the molecular mechanisms underlying disease pathogenesis.
We address the above aims by applying a muti-omics approach combining genomics with the study of multiple molecular phenotypes including transcriptomes, proteomes, metabolomes, methylomes and gut microbiomes. We characterize each biological separately, but also integrate data across molecular levels to obtain comprehensive biological signatures influencing higher-level phenotypes. We also complement our findings through dynamic experiments in primary cell culture to better characterize the molecular pathways under study. Uncovering and understanding these signatures enables precision medicine approaches and empowers translation for disease management and treatment.