The research group is dedicated to developing innovative tools and technologies that advance bioscience discovery. These efforts aim to deepen our understanding of the biological processes underlying human health and disease. A key objective of the group is to drive both structural and scientific advancements that enhance public health and contribute to the resilience and sustainability of our economy, society, and environment.
The group’s research focuses on the development and application of structural mass spectrometry (MS) techniques to investigate the structure, dynamics, and function of challenging membrane proteins. These proteins are the primary targets of most known drugs, yet their structural characterization remains limited due to the lack of tools capable of accurately capturing their conformational states under physiologically relevant conditions. To address this gap, the group is advancing hydrogen-deuterium exchange mass spectrometry (HDX-MS) to explore the dynamic signatures of membrane proteins and their complexes, providing critical insights into their function and molecular mechanisms.
The group is leading HORIZON-WIDERA-2023-TALENTS-01-01, “MASSTRUCT” Project to establish biomolecular and structural mass spectrometry for the analysis of complex biological pathways in BSRC “Alexander Fleming” (www.masstruct.org)
