George Kollias Research Group

2024

Christodoulou-Vafeiadou E, Geka C, Iliopoulou L, Ntari L, Denis MC, Karagianni N, Kollias G. 2024, "A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus.", Arthritis Rheumatol., doi: 10.1002/art.42830. Online ahead of print. [PubMed].

Papadopoulou D, Mavrikaki V, Charalampous F, Tzaferis C, Samiotaki M, Papavasileiou KD, Afantitis A, Karagianni N, Denis MC, Sanchez J, Lane JR, Faidon Brotzakis Z, Skretas G, Georgiadis D, Matralis AN, Kollias G. 2024, "Discovery of the First-in-Class Inhibitors of Hypoxia Up-Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation.", Angew Chem Int Ed Engl., e202319157. doi: 10.1002/anie.202319157. Online ahead of print. [PubMed].

Bagratuni T, Aktypi F, Theologi O, Sakkou M, Verrou KM, Mavrianou-Koutsoukou N, Patseas D, Liacos C, Skourti S, Papadimou A, Taouxi K, Theodorakakou F, Kollias G, Sfikakis P, Terpos E, Dimopoulos MA, Kastritis E. 2024, "Single-cell analysis of MYD88L265P and MYD88WT Waldenström macroglobulinemia patients.", Hemasphere., 8(2):e27. [PubMed].

2023

Fragoulis GE, Vetsika EK, Kyriakidi M, Verrou KM, Kollias G, Tektonidou MG, McInnes IB, Sfikakis PP. 2023, "Distinct innate and adaptive immunity phenotypic profile at the circulating single-cell level in Psoriatic Arthritis.", Clin Immunol., 253:109679. [PubMed].

Elhai M, Micheroli R, Houtman M, Mirrahimi M, Moser L, Pauli C, Bürki K, Laimbacher A, Kania G, Klein K, Schätzle P, Bertoncelj MF, Edalat SG, Keusch L, Khmelevskaya A, Toitou M, Geiss C, Rauer T, Sakkou M, Kollias G, Armaka M, Distler O, Ospelt C. 2023, "The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis.", Nat Commun., 14(1):8172. [PubMed].

Vlachogiannis NI, Evangelou K, Ntari L, Nikolaou C, Denis MC, Karagianni N, Veroutis D, Gorgoulis V, Kollias G, Sfikakis PP. 2023, "Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology.", Mech Ageing Dev., 214:111856. [PubMed].

Chalkidi N, Melissari MT, Henriques A, Stavropoulou A, Kollias G, Koliaraki V. 2023, "Activation and Functions of Col6a1+ Fibroblasts in Colitis-Associated Cancer.", Int J Mol Sci., 25(1):148 [PubMed].

Tzaferis C, Karatzas E, Baltoumas FA, Pavlopoulos GA, Kollias G, Konstantopoulos D. 2023, "SCALA: A complete solution for multimodal analysis of single-cell Next Generation Sequencing data.", Comput Struct Biotechnol J., 21:5382-5393. [PubMed].

Papadopoulou D, Roumelioti F, Tzaferis C, Chouvardas P, Pedersen AK, Charalampous F, Christodoulou-Vafeiadou E, Ntari L, Karagianni N, Denis MC, Olsen JV, Matralis AN, Kollias G. 2023, "Repurposing antipsychotic drug Amisulpride for targeting synovial fibroblast activation in arthritis", JCI insight, 8(9); e165024 [PubMed] [JCI Insight].

2022

Koliaraki V, Dotto GP, Buckley CD, Kollias G. 2022, "Mesenchymal cells in health and disease", Nat Immunol., 23(10): 1395-1398. [PubMed].

Tzaferis C, Karatzas E, Baltoumas FA, Pavlopoulos GA, Kollias G, Konstantopoulos D. 2022, "SCALA: A web application for multimodal analysis of single cell next generation sequencing data", bioRxiv, [doi].

Yan M, Komatsu N, Muro R, Huynh NCN, Tomofuji Y, Okada Y, Suzuki HI, Takaba H, Kitazawa R, Kitazawa S, Pluemsakunthai W, Mitsui Y, Satoh T, Okamura T, Nitta T, Im SH, Kim CJ, Kollias G, Tanaka S, Okamoto K, Tsukasaki M, Takayanagi H. 2022, "ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts", Nat Immunol. , doi: 10.1038/s41590-022-01285-0 [PubMed].

Papadopoulou D, Roumelioti F, Tzaferis C, Chouvardas P, Pedersen AK, Charalampous F, Christodoulou-Vafeiadou E, Ntari L, Karagianni N, Denis M, Olsen JV, Matralis AN, Kollias G. 2022, "Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis", bioRxiv, [doi].

Armaka M, Konstantopoulos D, Tzaferis C, Lavigne MD, Sakkou M, Liakos A, Sfikakis PP, Dimopoulos MA, Fousteri M & Kollias G. 2022, "Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis.", Genome Med. , 14(1) :78. [PubMed].

Roumelioti F, Tzaferis C, Konstantopoulos D, Papadopoulou D, Prados A, Sakkou M, Liakos A, Chouvardas P, Meletakos T, Pandis Y, Karagianni N, Denis M, Fousteri M, Armaka M, Kollias G. 2022, "miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis", bioRxiv, [doi].

Ehlich H, Cater HL, Flenniken AM, Goncalves Da Cruz I, Mura AM, Ntafis V, Raess M, Selloum M, Stoeger C, Suchanova S, Vuolteenaho R, Brown SDM, Hérault Y, Hinttala R, Hrabě de Angelis M, Kollias G, , Kontoyiannis DL, Malissen B, McKerlie C, Sedláček R, Wells SE, Zarubica A, Rozman J, Sorg T. 2022, "INFRAFRONTIER quality principles in systemic phenotyping.", Mamm Genome., 2022 Mar; 33(1):120-122. [PubMed].

Iliopoulou L, Kollias G. 2022, "Harnessing murine models of Crohn's disease ileitis to advance concepts of pathophysiology and treatment", Mucosal Immunol., 15(1): 10-26 [PubMed].

Akhmedov A, Crucet M, Simic B, Kraler S, Bonetti NR, Ospelt C, Distler O, Ciurea A, Liberale L, Jauhiainen M, Metso J, Miranda M, Cydecian R, Schwarz L, Fehr V, Zilinyi R, Amrollahi-Sharifabadi M, Ntari L, Karagianni N, Ruschitzka F, Laaksonen R, Vanhoutte PM, Kollias G, Camici GG, Lüscher TF. 2022, "TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies", Cardiovasc Res., 118(1): 254-266. [PubMed].

2021

Melissari MT, Henriques A, Tzaferis C, Prados A, Sarris ME, Chalkidi N, Mavroeidi D, Chouvardas P, Grammenoudi S, Kollias G, Koliaraki V. 2021, "Col6a1⁺/CD201⁺ mesenchymal cells regulate intestinal morphogenesis and homeostasis", Cell Mol Life Sci., 79(1):1. [PubMed].

Ntari L, Mantzouratou P, Katsaouni A, Pantos C, Kollias G, Mourouzis I. 2021, "Changes in Thyroid Hormone Signaling Mediate Cardiac Dysfunction in the Tg197 Mouse Model of Arthritis: Potential Therapeutic Implications", J Clin Med., 10(23):5512.  [PubMed].

Kostaki EG, Pavlopoulos GA, Verrou KM, Ampatziadis-Michailidis G, Harokopos V, Hatzis P, Moulos P, Siafakas N, Pournaras S, Hadjichristodoulou C, Chatzopoulou F, Chatzidimitriou D, Panagopoulos P, Lourida P, Argyraki A, Lytras T, Sapounas S, Gerolymatos G, Panagiotakopoulos G, Prezerakos P, Tsiodras S, Sypsa V, Hatzakis A, Anastassopoulou C, Spanakis N, Tsakris A, Dimopoulos MA, Kotanidou A, Sfikakis P, Kollias G, Magiorkinis G, Paraskevis D. 2021, "Molecular Epidemiology of SARS-CoV-2 in Greece Reveals Low Rates of Onward Virus Transmission after Lifting of Travel Restrictions Based on Risk Assessment during Summer 2020.", mSphere. , 6(3):e0018021. [PubMed].

Sfikakis PP, Verrou KM, Ampatziadis-Michailidis G, Tsitsilonis O, Paraskevis D, Kastritis E, Lianidou E, Moutsatsou P, Terpos E, Trougakos I, Chini V, Manoloukos M, Moulos P, Pavlopoulos GA, Kollias G, Hatzis P, Dimopoulos MA. 2021, "Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced Asymptomatic Versus Clinical Infection", Front. Immunol., , 12:746203 [PubMed].

Papadopoulou D, Drakopoulos A, Lagarias P, Melagraki G, Kollias G, Afantitis A. 2021, "In Silico Identification and Evaluation of Natural Products as Potential Tumor Necrosis Factor Function Inhibitors Using Advanced Enalos Asclepios KNIME Nodes", Int. J. Mol. Sci., 22(19): 10220; [PubMed].

Papazian Ι, Tsoukala Ε, Boutou Α, Karamita Μ, Kambas Κ, Iliopoulou L, Fischer R, Kontermann RE, Denis MC, Kollias G, Lassmann H & Probert L. 2021, "Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice", J Neuroinflammation, 18(1):222. [PubMed].

Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G. 2021, "Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis", Cell Rep., May 25; 35(8):109168. [PubMed].

Davidson S, Coles M, Thomas T, Kollias G, Ludewig B, Turley S, Brenner M & Buckley CD. 2021, "Fibroblasts as immune regulators in infection, inflammation and cancer", Nat Rev Immunol., 21(11):704-717. [PubMed].

Ntari L, Nikolaou C, Kranidioti K, Papadopoulou D, Christodoulou-Vafeiadou E, Chouvardas P, Meier F, Geka C, Denis MC, Karagianni N, Kollias G. 2021, "Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment", J Transl Med., 19: 165 [PubMed].

Prados A, Onder L, Cheng HW, Mörbe U, Lütge M, Gil-Cruz C, Perez-Shibayama C, Koliaraki V, Ludewig B, Kollias G. 2021, "Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity", Nat Immunol., 22(4):510-519. [PubMed].

Komatsu N, Win S, Yan M, Huynh NC, Sawa S, Tsukasaki M, Terashima A, Pluemsakunthai W, Kollias G, Nakashima T, Takayanagi H. 2021, "Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis", J Clin Invest., 131(6):143060. [PubMed].

Hayer S, Vervoordeldonk MJ, Denis MC, Armaka M, Hoffmann M, Bäcklund J, Nandakumar KS, Niederreiter B, Geka C, Fischer A, Woodworth N, Blüml S, Kollias G, Holmdahl R, Apparailly F, Koenders MI. 2021, "'SMASH' recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models. ", Ann Rheum Dis., 80(6):714-726. [PubMed].

Verrou KM, Vlachogiannis NI, Ampatziadis-Michailidis G, Moulos P, Pavlopoulos GA, Hatzis P, Kollias G, Sfikakis PP. 2021, "Distinct transcriptional profile of blood mononuclear cells in Behcet's disease: insights into the central role of neutrophil chemotaxis", Rheumatology (Oxford), 60(10):4910-4919. [PubMed].

Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. 2021, "Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation", Immunity., 54(3):468-483.e5. [PubMed].

2020

Koliaraki V, Prados A, Armaka M, Kollias G. 2020, "The mesenchymal context in inflammation, immunity and cancer.", Nat Immunol., 21(9): 974-982. Review. [PubMed].

Christodoulou-Vafeiadou E, Geka C, Ntari L, Kranidioti K, Argyropoulou E, Meier F, Armaka M, Mourouzis I, Pantos C, Rouchota M, Loudos G, Denis MC, Karagianni N, Kollias G. 2020, "Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis.", Arthritis Res Ther., 22(1) :232 [PubMed].

Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. 2020, "Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.", Nature, 580(7804) :524-529. [PubMed].

Ninou I, Sevastou I, Magkrioti C, Kaffe E, Stamatakis G, Thivaios S, Panayotou G, Aoki J, Kollias G, Aidinis V. 2020, "Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.", PLoS One, 15(4) :e0226050 [PubMed].

Koliaraki V, Henriques A, Prados A, Kollias G. 2020, "Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme.", J Exp Med., 217 (4). [PubMed].

2019

Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, Wirtz S, Thoma OM, Kramer V, Waldner MJ, Büttner C, Farin HF, Pešić M, Knieling F, Merkel S, Grüneboom A, Gunzer M, Grützmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. 2019, "STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.", Gut., 2019 Nov 4. pii: gutjnl-2019-319200. doi: 10.1136/gutjnl-2019-319200. [Epub ahead of print] [PubMed].

Patsalos A, Tzerpos P, Halasz L, Nagy G, Pap A, Giannakis N, Lyroni K, Koliaraki V, Pintye E, Dezso B, Kollias G, Spilianakis CG, Nagy L. 2019, "The BACH1-HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration.", J Immunol., 2019 Sep 15; 203(6):1532-1547. doi: 10.4049/jimmunol.1900553. Epub 2019 Aug 12. [PubMed].

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M. 2019, "A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.", Nat Cell Biol., 2019 May 13. doi: 10.1038/s41556-019-0324-3. [Epub ahead of print] [PubMed].

Karagianni N, Kranidioti K, Fikas N, Tsochatzidou M, Chouvardas P, Denis MC, Kollias G, Nikolaou C. 2019, "An integrative transcriptome analysis framework for drug efficacy and similarity reveals drug-specific signatures of anti-TNF treatment in a mouse model of inflammatory polyarthritis.", PLoS Comput Biol., 2019 May 9; 15(5):e1006933. doi: 10.1371/journal.pcbi.1006933. eCollection 2019 May. [PubMed].

Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V. 2019, "RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury", Cell Death Differ., 2019 Apr 15. doi: 10.1038/s41418-019-0330-9. [Epub ahead of print] [PubMed].

Kerdidani D, Chouvardas P, Arjo AR, Giopanou I, Ntaliarda G, Guo YA, Tsikitis M, Kazamias G, Potaris K, Stathopoulos GT, Zakynthinos S, Kalomenidis I, Soumelis V, Kollias G, Tsoumakidou M. 2019, "Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma.", Nat Commun., 2019 Mar 29; 10(1):1405. [PubMed].

Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C. 2019, "Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation", Gastroenterology, 2019 Mar; 156(4):1082-1097.e11. doi: 10.1053/j.gastro.2018.11.029. Epub 2018 Nov 16. [PubMed].

Bonetti NR, Diaz-Cañestro C, Liberale L, Crucet M, Akhmedov A, Merlini M, Reiner MF, Gobbato S, Stivala S, Kollias G, Ruschitzka F, Lüscher TF, Beer JH, Camici GG. 2019, "Tumour Necrosis Factor-α Inhibition Improves Stroke Outcome in a Mouse Model of Rheumatoid Arthritis.", Sci Rep., 2019 Feb 18; 9(1):2173. doi: 10.1038/s41598-019-38670-z. [PubMed].

Koliaraki V, Chalkidi N, Henriques A, Tzaferis C, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G. 2019, "Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.", Cell Rep., 2019 Jan 15; 26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072 [PubMed].

2018

Behren A, Speidel D, Kollias G, Howell VM. 2018, "Introduction to Mammalian Genome special issue: inflammation and immunity in cancer.", Mamm Genome., 2018 Dec; 29(11-12):691-693. doi: 10.1007/s00335-018-9787-y. [PubMed].

Cambré I, Gaublomme D, Burssens A, Jacques P, Schryvers N, De Muynck A, Meuris L, Lambrecht S, Carter S, de Bleser P, Saeys Y, Van Hoorebeke L, Kollias G, Mack M, Simoens P, Lories R, Callewaert N, Schett G, Elewaut D. 2018, "Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.", Nat Commun., 2018 Nov 5; 9(1):4613. doi: 10.1038/s41467-018-06933-4 [PubMed].

Kerdidani D, Magkouta S, Chouvardas P, Karavana V, Glynos K, Roumelioti F, Zakynthinos S, Wauters E, Janssens W, Lambrechts D, Kollias G, Tsoumakidou M. 2018, "Cigarette Smoke-Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells.", J Immunol., 2018 Sep 1; 201(5):1558-1569. doi: 10.4049/jimmunol.1700700. Epub 2018 Jul 23. [PubMed].

Melagraki G, Leonis G, Ntougkos E, Rinotas V, Papaneophytou C, Mavromoustakos T, Kontopidis G, Douni E, Kollias G, Afantitis A. 2018, "Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).", Curr Top Med Chem., 2018; 18(8):661-673. doi: 10.2174/1568026618666180607084430 [PubMed].

Melagraki G, Ntougkos E, Papadopoulou D, Rinotas V, Leonis G, Douni E, Afantitis A, Kollias G. 2018, "In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).", Front Pharmacol., doi: 10.3389/fphar.2018.00800 [PubMed].

Henriques A, Koliaraki V, Kollias G. 2018, "Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis", Proc Natl Acad Sci U S A., 2018 Jun 12; 115(24):E5546-E5555. doi: 10.1073/pnas.1805683115 [PubMed].

Sakkou M, Chouvardas P, Ntari L, Prados A, Moreth K, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Denis M, Karagianni N, Kollias G. 2018, "Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis", JCI Insight [PubMed].

Ntari L, Sakkou M, Chouvardas P, Mourouzis I, Prados A, Denis MC, Karagianni N, Pantos C, Kollias G. 2018, "Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis", Ann Rheum Dis., doi: 10.1136/annrheumdis-2017-212597 [PubMed], [see also ARD Editorial].

Armaka M, Ospelt C, Pasparakis M, Kollias G. 2018, "The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts", Nat Commun., 12;9(1):618 [PubMed] [Research Highlight in Nat Rev Rheumat].

2017

Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, Nakashima T, Takayanagi H. 2017, "Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver", Biochem Biophys Res Commun., 2017 Nov 4; 493(1):437-443. doi: 10.1016/j.bbrc.2017.09.004. Epub 2017 Sep 5. [PubMed].

Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G. 2017, "Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.", Sci Rep., 2017 May 25; 7(1):2397. doi: 10.1038/s41598-017-02581-8. [PubMed].

Ntougkos E, Chouvardas P, Roumelioti F, Ospelt C, Frank-Bertoncelj M, Filer A, Buckley CD, Gay S, Nikolaou C, Kollias G. 2017, "Genomic responses of mouse synovial fibroblasts during TNF-driven arthritogenesis greatly mimic those of human rheumatoid arthritis", Arthritis Rheumatol, 2017 Apr 13. doi: 10.1002/art.40128 [PubMed].

Melagraki G, Ntougkos E, Rinotas V, Papaneophytou C, Leonis G, Mavromoustakos T, Kontopidis G, Douni E, Afantitis A, Kollias G. 2017, "Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)", PLoS Comput Biol., 2017 Apr 20; 13(4):e1005372. doi: 10.1371/journal.pcbi.1005372 [PubMed].

Koliaraki V, Pallangyo CK, Greten FR, Kollias G. 2017, "Mesenchymal Cells in Colon Cancer", Gastroenterology, 2017 Apr;152(5): 964-979. doi: 10.1053/j.gastro.2016.11.049. Review [PubMed].

Frank-Bertoncelj M, Trenkmann M, Klein K, Karouzakis E, Rehrauer H, Bratus A, Kolling C, Armaka M, Filer A, Michel BA, Gay RE, Buckley CD, Kollias G, Gay S, Ospelt C. 2017, "Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions", Nat Commun., 2017 Mar 23; 8:14852. doi: 10.1038/ncomms14852 [PubMed].

2016

Michopoulos F, Karagianni N, Whalley NM, Firth MA, Nikolaou C, Wilson ID, Critchlow SE, Kollias G, Theodoridis GA. 2016, "Targeted metabolic profiling of the Tg197 mouse model reveals itaconic acid as a marker of Rheumatoid Arthritis.", J Proteome Res., 2016 Oct 5. [Epub ahead of print] [PubMed].

Vrontaki E, Melagraki G, Afantitis A, Mavromoustakos T, Kollias G. 2016, "Searching for novel Janus kinase-2 inhibitors using a combination of pharmacophore modeling, 3D QSAR studies and virtual screening", Mini Rev Med Chem., 2016 Sep 19. [Epub ahead of print] [PubMed].

Prados A, Kollias G, Koliaraki V. 2016, "CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs", Sci Rep., 2016 Sep 8; 6:33027. doi:10.1038/srep33027. [PubMed].

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR 2016, "Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression", Ann Rheum Dis., 2016 Sep 5. pii: annrheumdis-2016-209424. doi:10.1136/annrheumdis-2016-209424. [Epub ahead of print] [PubMed].

Chouvardas P Kollias G, Nikolaou C. 2016, "Inferring active regulatory networks from gene expression data using a combination of prior knowledge and enrichment analysis", BMC Bioinformatics, 2016 Jun 6; 17 Suppl 5:181. doi:10.1186/s12859-016-1040-7 [PubMed].

Wroblewski R, Armaka M, Kondylis V, Pasparakis M, Walczak H, Mittrücker HW, Schramm C, Lohse AW, Kollias G, Hanno E. 2016, "Opposing Role of Tumor Necrosis Factor Receptor 1 Signaling in T Cell Mediated Hepatitis and Bacterial Infection In Mice.", Hepatology, 2016 Mar 17. doi: 10.1002/hep.28551. [Epub ahead of print] [PubMed].

Segueni N, Benmerzoug S, Rose S, Gauthier A, Bourigault ML, Reverchon F, Philippeau A, Erard F, Le Bert M, Bouscayrol H, Wachter T, Garcia I, Kollias G, Jacobs M, Ryffel B, Quesniaux VF. 2016, "Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection", Sci Rep., 2016 Mar 2; 6:22454. doi: 10.1038/srep22454 [PubMed].

Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, Szondy Z. 2016, "Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications.", J Immunol., 2016 Jan 4. pii: 1501573. [Epub ahead of print] [PubMed].

2015

Habbas S, Santello M, Becker D, Stubbe H, Zappia G, Liaudet N, Klaus FR, Kollias G, Fontana A, Pryce CR, Suter T, Volterra A. 2015, "Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling.", Cell., 2015 Dec 17; 163(7):1730-41. doi: 10.1016/j.cell.2015.11.023. Epub 2015 Dec 10. [PubMed].

Kollias G, Lambris JD. 2015, "A 'rule of 3' to revive Greek science, research and innovation.", Nat Immunol, 2015 Nov; 16(12):1206-8. doi: 10.1038/ni.3322 [PubMed].

Koliaraki V, Pasparakis M, Kollias G 2015, "IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer", J Exp Med, 2015 Nov 30. pii: jem.20150542. [Epub ahead of print] [PubMed].

Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado GC, Lira SA, Kollias G 2015, "Host and microbiota interactions are critical for development of murine Crohn's-like ileitis", Mucosal Immunol, 2015 Oct 21. doi: 10.1038/mi.2015.102. [Epub ahead of print] [PubMed].

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie AN, Caamaño JH 2015, "Inflammation-induced formation of fat-associated lymphoid clusters", Nat Immunol, 2015 Aug; 16(8):819-28. doi: 10.1038/ni.3215 [PubMed].

Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T, Takayanagi H. 2015, "RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation", Ann Rheum Dis., 2015 May 29. doi: 10.1136/annrheumdis-2014-207137. [Epub ahead of print] [PubMed].

INFRAFRONTIER Consortium. 2015, "INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community", Nucleic Acids Res., 2015. Jan; 43(Database issue):D1171-5. [PubMed].

2014

Roulis M, Nikolaou C, Kotsaki E, Kaffe E, Karagianni N, Koliaraki V, Salpea K, Ragoussis J, Aidinis V, Martini E, Becker C, Herschman HR, Vetrano S, Danese S, Kollias G. 2014, "Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis", Proc Natl Acad Sci U S A. , 2014 Oct 28; 111(43):E4658-67. doi: 10.1073/pnas.1415762111. Epub 2014 Oct 14. [PubMed].

Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, Pasparakis M 2014, "Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout", Cell Death Differ, 2014 Jun 27. doi: 10.1038/cdd.2014.83. [Epub ahead of print] [PubMed].

Hemmerling J, Heller K, Hörmannsperger G, Bazanella M, Clavel T, Kollias G, Haller D 2014, "Fetal exposure to maternal inflammation does not affect postnatal development of genetically-driven ileitis and colitis", PLoS One., 2014 May 21; 9(5):e98237. [PubMed].

Leppkes M, Roulis M, Neurath MF, Kollias G ,Becker C. 2014, "The pleiotropic functions of TNF-α in the regulation of the intestinal epithelial response to inflammation", Int Immunol. , 2014 May 12 [Epub ahead of print] [PubMed].

Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, O'Garra A, Prinz M, Kollias G ,Ley SC. 2014, "Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase", J Immunol. , 2014 Mar 17. [Epub ahead of print] [PubMed].

2013

Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G ,Toftgard R, Sabat R, Pasparakis M, Haase I. 2013, "Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.", Immunity. , 2013 Nov 14;39(5): 899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7. [PubMed].

Furtado GC, Pacer ME, Bongers G, Bénézech C, He Z, Chen L, Berin MC, Kollias G ,Caamaño JH, Lira SA. 2013, "TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells.", Mucosal Immunol. , 2013 Oct 16. doi: 10.1038/mi.2013.79. [Epub ahead of print] [PubMed].

Van Hauwermeiren F, Armaka M, Karagianni N, Kranidioti K, Vandenbroucke RE, Loges S, Van Roy M, Staelens J, Puimège L, Palagani A, Berghe WV, Victoratos P, Carmeliet P, Libert C, Kollias G. 2013, "Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.", J Clin Invest. , 2013 Jun 3;123(6):2590-603. doi: 10.1172/JCI65624. Epub 2013 May 15. [PubMed].

Jacques P, Lambrecht S, Verheugen E, Pauwels E, Kollias G, Armaka M, Verhoye M, Van der Linden A, Achten R, Lories RJ, Elewaut D. 2013, "Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells.", Ann Rheum Dis. , 2013 Aug 6. doi: 10.1136/annrheumdis-2013-203643. [Epub ahead of print] [PubMed].

2012

Koliaraki V, Roulis M, Kollias G. 2012, "Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.", J Clin Invest. , 2012 Oct 15. pii: 63917. doi: 10.1172/JCI63917. [Epub ahead of print] [PubMed].

Maniatis NA, Sfika A, Nikitopoulou I, Vassiliou AG, Magkou C, Armaganidis A, Roussos C, Kollias G, Orfanos SE, Kotanidou A. 2012, "Acid-Induced Acute Lung Injury in Mice Associates with p44/42 and c-Jun N-Terminal Kinase Activation and Requires the Function of Tumor Necrosis Factor-α Receptor I.", Shock. , 2012 Jul 18. [Epub ahead of print] [PubMed].

Nikolaou K., Tsagaratou A., Eftychi C., Kollias G., Mosialos G., Talianidis I . 2012, "Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer.", Cancer Cell . , 21: , 738-750 [PubMed].

Olleros ML, Vesin D, Bisig R, Santiago-Raber ML, Schuepbach-Mallepell S, Kollias G., Gaide O, Garcia I. 2012, "Membrane-Bound TNF Induces Protective Immune Responses to M. bovis BCG Infection: Regulation of memTNF and TNF Receptors Comparing Two memTNF Molecules.", PLoS One. , 2012;7(5):e31469. , Epub 2012 May 30. [PubMed].

Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G. 2012, "Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model.", Ann Rheum Dis. , 2012 May 5. [Epub ahead of print] [PubMed].

Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V. 2012, "Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.", J Exp Med., 2012 Apr 9. [Epub ahead of print] [PubMed].

Mouchlis VD, Melagraki G, Mavromoustakos T, Kollias G. , Afantitis A. 2012, "Molecular Modeling on Pyrimidine-Urea Inhibitors of TNF-α Production: An Integrated Approach Using a Combination of Molecular Docking, Classification Techniques, and 3D-QSAR CoMSIA.", Chem Inf Model. , 2012 Mar 15. [Epub ahead of print] [PubMed].

Eftychi C, Karagianni N, Alexiou M, Apostolaki M, Kollias G. 2012, "Myeloid takl acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.", PLoS One., 2012;7(2):e31550. Epub 2012 Feb 14. [PubMed].

Xiao F, Juric M, Li J, Riederer B, Yeruva S, Singh AK, Zheng L, Glage S Kollias G, Dudeja P, Tian DA, Xu G, Zhu J, Bachmann O, Seidler U. 2012, "Loss of downregulated in adenoma (DRA) impairs mucosal HCO(3) (-) secretion in murine ileocolonic inflammation.", Inflamm Bowel Dis. , 2012 Jan;18(1) :101-11. doi: 10.1002/ibd.21744. Epub 2011 May 6 [PubMed].

2011

Tsakiri N, Papadopoulos D, Denis MC, Mitsikostas DD, Kollias G. . 2011, "TNFR2 on non-haematopoietic cells is required for Foxp3+ regulatory T-cell function and disease suppression in experimental autoimmune encephalomyelitis.", Eur J Immunol. , 2011 Nov 22. doi: 10.1002/eji.201141659. [Epub ahead of print] [PubMed].

Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G. 2011, "A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.", Hum Mol Genet. , 2011 Nov 7. [Epub ahead of print] [PubMed].

Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LA, van den Berg WB, Kollias G. , Eckes B, Pap T. 2011, "The loss of integrin α2β1 suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.", Arthritis Rheum. , 2011 Nov 14. doi: 10.1002/art.33487. [Epub ahead of print] [PubMed].

Baur P, Martin FP, Gruber L, Bosco N, Brahmbhatt V, Collino S, Guy P, Montoliu I, Rozman J, Klingenspor M, Tavazzi I, Thorimbert A, Rezzi S, Kochhar S, Benyacoub J, Kollias G. , Haller D. 2011, "Metabolic Phenotyping of the Crohn's Disease-like IBD Etiopathology in the TNF(ΔARE/WT) Mouse Model.", J Proteome Res. , 2011 Oct 26. [Epub ahead of print] [PubMed].

Koliaraki V, Kollias G. 2011, "A New Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis.", Adv Exp Med Biol. , 2012; 780:101-11. [PubMed].

Kollias G, Papadaki P, Apparailly F, Vervoordeldonk MJ, Holmdahl R, Baumans V, Desaintes C, Di Santo J, Distler J, Garside P, Hegen M, Huizinga TW, Jüngel A, Klareskog L, McInnes I, Ragoussis I, Schett G, Hart BT, Tak PP, Toes R, van den Berg W, Wurst W, Gay S. 2011, "Animal models for arthritis: innovative tools for prevention and treatment.", Ann Rheum Dis. , 2011 May 30. [Epub ahead of print] [PubMed].

Roulis M, Armaka M, Manoloukos M, Apostolaki M, Kollias G. 2011, "Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.", Proc Natl Acad Sci U S A , 2011 Mar 14. [Epub ahead of print]. [PubMed].

Afantitis A, Melagraki G, Koutentis PA, Sarimveis H, Kollias G. 2011, "Ligand-based virtual screening procedure for the prediction and the identification of novel β-amyloid aggregation inhibitors using Kohonen maps and Counterpropagation Artificial Neural Networks.", Eur J Med Chem., 2011 Feb; 46(2):497-508. [PubMed].

Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M, Kollias G, Straub RH, Sporns O, Doerfler A, Brune K, Schett G. 2011, "Blockade of TNF-{alpha} rapidly inhibits pain responses in the central nervous system.", Proc Natl Acad Sci U S A., 2011 Jan 18. [Epub ahead of print] [PubMed].

2010

Burmester GR, Lipsky PE, Dörner T; Kitasato Meeting Faculty. 2010, "Kitasato Symposium 2010: new prospects for cytokines.", Arthritis Res Ther. , 2010; 12(6):301. Epub 2010 Dec 17. [PubMed].

Melagraki G, Afantitis A, Sarimveis H, Igglessi-Markopoulou O, Koutentis PA, Kollias G. 2010, "In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives.", Chem Biol Drug Des. , 2010 Nov; , 76(5):397-406 [PubMed].

Viejo-Borbolla A, Martin AP, Muniz LR, Shang L, Marchesi F, Thirunarayanan N, Harpaz N, Garcia RA, Apostolaki M, Furtado GC, Mayer L, Kollias G, Alcami A, Lira SA. 2010, "Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD.", Mucosal Immunol. , 2010 Jul 21., [Epub ahead of print] [PubMed].

Zouberakis M, Chandras C, Swertz M, Smedley D, Gruenberger M, Bard J, Schughart K, Rosenthal N, Hancock JM, Schofield PN, Kollias G, Aidinis V 2010, "Mouse Resource Browser--a database of mouse databases.", Database (Oxford). , Jul 6 2010, baq010. [PubMed].

Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hünig T, Schett G, David JP. 2010, "Regulatory T cells protect from local and systemic bone destruction in arthritis.", J Immunol. , 2010 Jun 15 , 184(12):7238-46. Epub 2010 May 17 [PubMed].

Blüml S, Binder NB, Niederreiter B, Polzer K, Hayer S, Tauber S, Schett G, Scheinecker C, Kollias G, Selzer E, Bilban M, Smolen JS, Superti-Furga G, Redlich K.. 2010, "Anti-inflammatory effects of TNF on hematopoietic cells in the development of erosive arthritis.", Arthritis Rheum., 2010 Feb 12. , Epub ahead of print [PubMed].

Apostolaki M, Armaka M, Victoratos P, Kollias G. 2010, "Cellular Mechanisms of TNF Function in Models of Inflammation and Autoimmunity.", Curr Dir Autoimmun., 2010;11:1-26, Epub 2010 Feb 18. [PubMed].

Jacques P, Venken K, Van Beneden K, Hammad H, Seeuws S, Drennan MB, Deforce D, Verbruggen G, Apostolaki M, Kollias G, Lambrecht BN, De Vos M, Elewaut D. 2010, "Invariant natural killer T cells are natural regulators of spondyloarthritis.", Arthritis Rheum., 2010 Jan 21. , Epub ahead of print [PubMed].

Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium , de Angelis MH, Brown SD, Hancock JM, Mallon AM., 2010, "EuroPhenome: a repository for high-throughput mouse phenotyping data.", Nucleic Acids Res, 2010 Jan;38(Database issue):, D577-85. Epub 2009 Nov 23.; [PubMed].

2009

Christina Chandras, Thomas Weaver, Michael Zouberakis, Damian Smedley, Klaus Schughart, Nadia Rosenthal, John M. Hancock, George Kollias, Paul N. Schofield, and Aidinis V., 2009, "Models for financial sustainability of biological databases and resources ", Database (2009), Vol. 2009, , bap017; [PubMed].

Böhm C, Hayer S, Kilian A, Zaiss MM, Finger S, Hess A, Engelke K, Kollias G, Krönke G, Zwerina J, Schett G, David JP. , 2009, "The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss.", J Immunol. , 2009 Nov 1 183(9):5938-47. Epub 2009 Oct 14 [Pubmed]

Johansen C, Vestergaard C, Kragballe K, Kollias G, Gaestel M, Iversen L., 2009, "MK2 regulates the early stages of skin tumor promotion.", Carcinogenesis, 2009 Oct 6. [Epub ahead of print] [Pubmed]

Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P. 2009, "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.", Arthritis Res Ther., 2009 Sep 18;11(5):R138. [Epub ahead of print] , [PubMed]

Charles KA, Kulbe H, Soper R, Escorcio-Correia M, Lawrence T, Schultheis A, Chakravarty P, Thompson RG, Kollias G, Smyth JF, Balkwill FR, Hagemann T. 2009, "The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans.", J Clin Invest., 2009 Sep 8. pii: 39065. doi: 10.1172/JCI39065. [Epub ahead of print] , [PubMed]

Afantitis A, Melagraki G, Sarimveis H, Koutentis PA, Igglessi-Markopoulou O and Kollias G, 2009, "A combined LS-SVM & MLR QSAR workflow for predicting the inhibition of CXCR3 receptor by quinazolinone analogs", Mol Divers, 2009 May 30. [Epub ahead of print] .[Pubmed]

Sotiria Tzima, Panayiotis Victoratos, Ksanthi Kranidioti, Maria Alexiou and George Kollias, 2009, "Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production", J Exp Med, doi:10.1084/jem.20081582 .[Pubmed]

Maria Armaka, Vassiliki Gkretsi, Dimitris Kontoyiannis and George Kollias, 2009, "A standardized protocol for the isolation and culture of normal and arthritogenic murine synovial fibroblasts .", Nature Protocols , DOI: 10.1038/nprot.2009.102 .[Nature Protocols]

Melagraki G, Afantitis A, Sarimveis H, Koutentis PA, Kollias G, Igglessi-Markopoulou O. 2009, "Predictive QSAR workflow for the in silico identification and screening of novel HDAC inhibitors.", Mol Divers. , [Epub ahead of print], [PubMed].

Huang CH, Vallejo JG, Kollias G, Mann DL. 2009, "Role of the Innate Immune System in Acute Viral Myocarditis.", Basic Res Cardiol. , [Epub ahead of print], [PubMed].

Victoratos P, Kollias G . 2009, "Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells.", Immunity , 30(1):130-42 , [PubMed].

2008

Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, Kardakaris R, Polykratis A,, Kollias G, de Winther MP, Pasparakis M. 2008, "Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.", Cell Metab. , 2008 Nov;8(5):372-83, [PubMed].

Büning J, von Smolinski D, Tafazzoli K, Zimmer KP, Strobel S, Apostolaki M, Kollias G, Heath JK, Ludwig D, Gebert A. 2008, "Multivesicular bodies in intestinal epithelial cells: responsible for MHC class II-restricted antigen processing and origin of exosomes.", Immunology. , 2008 Aug 14. [Epub ahead of print], [PubMed].

Ermolaeva MA, Michallet MC, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M. 2008, "Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.", Nat Immunol. , 2008 Sep;9(9):1037-46. Epub 2008 Jul 20, [Pubmed].

Allie N, Alexopoulou L, Quesniaux VJ, Fick L, Kranidioti K, Kollias G, Ryffel B, Jacobs M. 2008, "Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection.", Immunology, 2008 Jun 9, [Pubmed].

Pullerits R, Jonsson IM, Kollias G, Tarkowski A. 2008, "Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling.", Arthritis Res Ther, 2008;10(3):R72, [Pubmed].

Antreas Afantitis, Georgia Melagraki, Haralambos Sarimveis, Olga Igglessi-Markopoulou, Kollias G, 2008, "A novel QSAR model for predicting the inhibition of CXCR3 receptor by 4-N-aryl-[1,4]diazepane ureas", European Journal of Medicinal Chemistry, 2008.05.028, [ScienceDirect].

Apostolaki M, Manoloukos M, Roulis M, Wurbel MA, Müller W, Papadakis KA, Kontoyiannis DL, Malissen B, Kollias G, 2008, "Role of beta7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease", Gastroenterology., 2008 Mar 5, Epub ahead of print [PubMed].

Huybers S, Apostolaki M, van der Eerden BC, Kollias G, Naber TH, Bindels RJ, Hoenderop JG. 2008, "Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca(2+) transporters", Inflamm Bowel Dis., 2008 Feb 11, Epub ahead of print [PubMed].

Maria Armaka, Maria Apostolaki, Peggy Jacques, Dimitris L. Kontoyiannis, Dirk Elewaut, Kollias G. 2008, "Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases", J Exp Med, 2008 Feb 4, 10.1084/jem.20070906 [PubMed].

Schurigt U, Hummel KM, Petrow PK, Gajda M, Stöckigt R, Middel P, Zwerina J, Janik T, Bernhardt R, Schüler S, Scharnweber D, Beckmann F, Saftig P, Kollias G ,Schett G, Wiederanders B, Bräuer R. 2008, "Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.", Arthritis Rheum., 2008 Jan 31, 58(2):422-434 [PubMed].

Bobacz K, Sunk IG, Hayer S, Amoyo L, Tohidast-Akrad M, Kollias G ,Smolen JS, Schett G. 2008, "Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: Potential importance for cartilage breakdown and synovial hypertrophy.", Arthritis Rheum., 2008 Jan, 58(1):109-18 [PubMed].

2007

Vasilopoulos Y, Gkretsi V, Armaka M, Aidinis V, Kollias G 2007, "Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.", Ann Rheum Dis., 2007 Nov, 66 Suppl 3:iii23-8 [PubMed].

Douni E, Armaka M, Kontoyiannis DL, Kollias G 2007, "Functional genetic and genomic analysis of modeled arthritis.", Adv Exp Med Biol., 2007, 602:33-42. [PubMed in process].

Van Molle W, Van Roy M, Van Bogaert T, Dejager L, Van Lint P, Vanlaere I, Sekikawa K, Kollias G , Libert C. 2007, "Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy.", Cancer Res., 2007 Aug 1, 67(15):7301-7. [PubMed].

Chatzidakis I, Fousteri G, Tsoukatou D, Kollias G , Mamalaki C. 2007, "An essential role for TNF in modulating thresholds for survival, activation, and tolerance of CD8+ T cells.", J Immunol., 2007 Jun 1, 178(11):6735-45. [PubMed].

The Mouse Phenotype Database Integration Consortium ( John M. Hancock, Niels C. Adams, Aidinis V., Andrew Blake, Judith A. Blake, Molly Bogue, Steve D. M. Brown, Elissa Chesler, Duncan Davidson, Christopher Duran, Janan T. Eppig, Valerie Gailus-Durner, Hilary Gates, Georgios V. Gkoutos, Simon Greenaway, Martin Hrabe´ De Angelis, Kollias George, Sophie Leblanc, Kirsty Lee, Christoph Lengger, Holger Maier, Ann-Marie Mallon, Hiroshi Masuya, David G. Melvin, Werner Mu ller, Helen Parkinson, Glenn Proctor, Eli Reuveni, Paul Schofield, Aadya Shukla, Cynthia Smith, Tetsuro Toyoda, Laurent Vasseur, Shigeharu Wakana, Alison Walling, Jacqui White, Joe Wood, Michalis Zouberakis) , 2007, "Integration of mouse phenome data resources", Mamm. Genome., 18(3):157-63., [Pubmed].

Ye P, Kollias G , D'Ercole AJ. 2007, "Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice.", J Neurosci Res., 2007 Feb 5, 85(4):712-722 [Epub ahead of print] [PubMed].

2006

Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A, Douni E, Blackshear PJ, Kontoyiannis DL, Kollias G 2006, "Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.", Eur J Immunol., 2006 Oct, 36(10):2768-80 [PubMed].

Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G ,Cleveland DW, 2006, "Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia.", Science, 2006 Jun 2, 312(5778):1389-92 [PubMed].

Bamias G, Mishina M, Nyce M, Ross WG, Kollias G Rivera-Nieves J, Pizarro TT, Cominelli F, 2006, "Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.", Proc Natl Acad Sci U S A., 2006 May 30, 103(22):8441-6 [PubMed].

Argyropoulos C, Chatziioannou AA, Nikiforidis G, Moustakas A, Kollias G ,Aidinis V., 2006, "Operational criteria for selecting a cDNA microarray data normalization algorithm.", Oncol rep., 2006, 15:983-996 [PubMed].

Zwerina J, Hayer S, Redlich K, Bobacz K, Kollias ,Smolen JS, Schett G., 2006, "Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction.", Arthritis Rheum., 2006 Jan 30, 54(2):463-472 [PubMed].

Victoratos P, Lagnel J, Tzima S, Alimzhanov MB, Rajewsky K, Pasparakis M, Kollias , 2006, "FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. ", Immunity., 2006 Jan, 24(1):65-77. [PubMed].

2005

Hayer S, Tohidast-Akrad M, Haralambous S, Jahn-Schmid B, Skriner K, Trembleau S, Dumortier H, Pinol-Roma S, Redlich K, Schett G, Muller S, Kollias , Smolen J, Steiner G., 2005, "Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-alpha transgenic mice.", J Immunol., 2005 Dec 15, 175(12):8327-36. [PubMed].

Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, Darragh J, McIlrath J, Carr JM, Armit LJ, Clacher C, Malone L, Kollias G, Arthur JS.,, 2005, "Generation and Characterization of p38{beta} (MAPK11) Gene-Targeted Mice", Mol Cell Biol., 2005 Dec, 25(23):10454-10464 [PubMed].

Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Moller S, Kazunori W, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y,Kollias G, 2005, "Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis", PLoS Genet., 2005 Oct, 1(4):e48 [PubMed].

Hovelmeyer N, Hao Z, Kranidioti K, Kassiotis G, Buch T, Frommer F, von Hoch L, Kramer D, Minichiello L, Kollias G , Schett G., 2005, "Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis ", J Immunol., 2005 Nov 1;175(9), 5875-84 [PubMed].

Zwerina J, Tzima S, Hayer S, Redlich K, Hoffmann O, Hanslik-Schnabel B, Smolen JS, Kollias G , Lassmann H, Waisman A., 2005, "Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption, FASEB J., 2005 Oct 18, [PubMed].

Katsanou V, Papadaki O, Milatos S, Blackshear PJ, Anderson P, Kollias G., Kontoyiannis DL., 2005, "HuR as a negative posttranscriptional modulator in inflammation", Mol Cell., 2005 Sep 16;19(6):, 777-89 [PubMed].

Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H Kollias G., Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)., 2005, "The transcriptional landscape of the mammalian genome", Science 2005 Sep 2;309(5740), 1559-63 [PubMed].

Kollias G., 2005, "TNF pathophysiology in murine models of chronic inflammation and autoimmunity", Semin Arthritis Rheum., 2005 Apr;34(5 Suppl1), 3-6. Review. [PubMed].

2004

Panagopoulos D., Victoratos P., Alexiou M., Kollias G., Mosialos G., 2004, "Comparative analysis of signal transduction by CD40 and the Epstein-Barr Virus Oncoprotein LMP1 in vivo", J. Virol., 78 (3), 13253-61 [PubMed].

Staelens J., Puimege L., Mahieu T., Pynaert G., Hochepied T., Vandenabeele A., Grooten J., Kontoyiannis D., Van Roy F., Kollias G., Libert C., 2004, "Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders", Mamm. Genome., 15, 537-543 [PubMed].

Auwerx J., Avner P., Baldock R., Ballabio A., Balling R., Barbacid M., Berns A., Bradley A., Brown S., Carmeliet P., Chambon P., Cox R., Davidson D., Davies K., Duboule D., Forejt J., Granucci F., Hastie N., de Angelis M. H., Jackson I., Kioussis D., Kollias G., Lathrop M., Lendahl U., Malumbres M., von Melchner H., Muller W., Partanen J., Ricciardi-Castagnoli P., Rigby P., Rosen B., Rosenthal N., Skarnes B., Stewart AF, Thornton J., Tocchini-Valentini G., Wagner E., Wahli W., Wurst W., 2004, "The European dimension for the mouse genome mutagenesis program", Nat. Genetics, 36, 925-7 [PubMed].

Smolen J. S., Hayer S., Schett G., Redlich K., Aringer M., Kollias G., Wagner E., Steiner G., 2004, "Autoimmunity and rheumatoid arthritis", Autoimmun. Rev., 3 Suppl 1, S23 [PubMed].

Kollias G., 2004, "Modeling the function of tumor necrosis factor in immune pathophysiology", Autoimmun. Rev., 3 Suppl 1, S24-5 [PubMed].

Xanthoulea S., Pasparakis M., Kousteni S., Brakebusch C., Wallach D., Bauer J., Lassmann H., Kollias G., 2004, "Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases", J. Exp. Med., 2;200 (3), 367-76 [PubMed].

Herrak P., Gortz B., Hayer S., Redlich K., Reiter E., Gasser J., Bergmeister H., Kollias G., Smolen J. S., Schett G., 2004, "Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis", Arthritis Rheum., 50 (7), 2327-37 [PubMed].

Thwin M. M., Douni E., Aidinis V., Kollias G., Kodama K., Sato K., Satish R. L., Mahendran R., Gopalakrishnakone P., 2004, "Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study", Arthritis Res. & Ther., 6 (3), R282-94 [PubMed].

Gortz B., Hayer S., Redlich K., Zwerina J., Tohidast-Akrad M., Tuerk B., Hartmann C., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation", J. Bone Miner. Res., 19 (6), 990-8 [PubMed].

Douni E., Alexiou M., Kollias G., 2004, "Genetic engineering in the mouse: tuning TNF/TNFR expression", Methods Mol. Med., 98, 137-70 [PubMed].

Redlich K., Gortz B., Hayer S., Zwerina J., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Overexpression of tumor necrosis factor causes bilateral sacroiliitis", Arthritis Rheum., 50 (3), 1001-5 [PubMed].

Douni E., Sfikakis P. P., Haralambous S., Fernandes P., Kollias G., 2004, "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols", Arthritis Res. & Ther., 6 (1), R65-R72 [PubMed].

Redlich K., Gortz B., Hayer S., Zwerina J., Doerr N., Kostenuik P., Bergmeister H., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis", Am. J. Pathol., 164 (2), 543-55 [PubMed].

Zwerina J., Hayer S., Tohidast-Akrad M., Bergmeister H., Redlich K., Feige U., Dunstan C., Kollias G., Steiner G., Smolen J., Schett G., 2004, "Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction", Arthritis Rheum., 50, 277-90 [PubMed].

2003

Schett G., Redlich K., Hayer S., Zwerina J., Bolon B., Dunstan C., Gortz B., Schulz A., Bergmeister H., Kollias G., Steiner G., Smolen J. S., 2003, "Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice", Arthritis Rheum., 48, 2042-51 [PubMed].

Sfikakis P. P., Kollias G., 2003, "Tumor necrosis factor biology in experimental and clinical arthritis", Curr. Op. Rheumatol., 15, 380-6 [PubMed].

Probst H. C., Lagnel J., Kollias G., van den Broek M., 2003, "Inducible transgenic mice reveal resting dentritic cells as potent inducers of CD8+ T cell tolerance", Immunity, 18, 713-720 [PubMed].

Aidinis V., Plows D., Haralambous S., Armaka M., Papadopoulos P., Kanaki M. Z., Koczan D., Thiessen H. J., Kollias G., 2003, "Functional analysis of an arthritogenic synovial fibroblast", Arthritis Res. & Ther., 5, 140-157 [PubMed].

Hukkanen M., Platts L. A., Haralambous S., Ainola M., Konttinen Y. T., Kollias G., Polak J. M., 2003, "Induction of Inducible Nitric Oxide Synthase, Argininosuccinate Synthase, and GTP Cyclohydrolase I in Arthritic Joints of Human Tumor Necrosis Factor-a Transgenic Mice", J. Rheumatol., 30, 652-9 [PubMed].

Ye P., Price W., Kassiotis G., Kollias G., D'Ercole A. J., 2003, "Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice", J. Neurosci. Res., 71, 721-31 [PubMed].

Akassoglou K., Douni E., Bauer J., Lassmann H., Kollias G., Probert L., 2003, "Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 100, 709-714 [PubMed].

2002

Holtmann M. H., Douni E., Schutz M., Zeller G., Mudter J., Lehr H. A., Gerspach J., Scheurich P., Galle P. R., Kollias G., Neurath M. F., 2002, "Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimenta colitis in vivo", Eur. J. Immunol., 32, 3142-51 [PubMed].

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizzaro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, "Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease", J. Exp. Med., 196, 1563-74 [PubMed].

Redlich K., Hayer S., Ricci R., David J.-P., Tohidast-Akrad M., Kollias G., Steiner G., Smolen G. S., Wagner E. F., Schett G., 2002, "Oscteoclasts are essential for TNF-α-mediated joint destruction", J. Clin. Invest., 110, 1419-1427 [PubMed].

Kollias G., Kontoyiannis D., 2002, "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments", Cytokine Growth Factor Rev., 13, 315-321 [PubMed].

Redlich K., Hayer S., Maier A., Dunstan C. R., Tohidast-Akrad M., Lang S., Turk B., Pietschmann P., Woloszezuk W., Haralambous S., Kollias G., Steiner G., Smolen J. S., Schett G., 2002, "Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin", Arthritis Rheum., 46, 785-92 [PubMed].

Kollias G., Kontoyiannis D., Douni E., Kassiotis G., 2002, "The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies", Curr. Dir. Autoimmun., 5, 30-50 [PubMed].

Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H.-D., Holtmann H., Kollias G., Gaestel M., 2002, "MK2 targets AU-rich elements and regulates biosynthesis of Tumor Necrosis Factor and Interleukin-6 independently at different post-transcriptional levels", J. Biol. Chem., 277, 3065-3068 [PubMed].

2001

Schett G., Hayer S., Tohidast-Akrad M., Jahn Schmid B., Lang S., Turk B., Kainberger F., Kollias G., Newby A. C., Xu Q., Steiner G., Smolen J., 2001, "Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints of TNFα-transgenic mice", Arthritis Rheum., 44, 2888-98 [PubMed].

Kassiotis G., Kranidioti K., Kollias G., 2001, "Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness", J. Neuroimmunol., 119, 239-47 [PubMed].

Kontoyiannis D., Kotlyarov A., Carballo E., Alexopoulou L., Blackshear P. J., Gaestel M., Davis R., Flavell R., Kollias G., 2001, "Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology", EMBO J., 20, 3760-3770 [PubMed].

Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., Vescovi A., Bagetta G., Kollias G., Meodolesi J., Volterra A., 2001, "CXCR4-activated astrocyte glytamate release via TNFα: amplification by microglia triggers neurotoxicity", Nat. Neurosci., 4, 702-10 [PubMed].

Kassiotis G., Kollias G., 2001, "TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models", J. Clin. Invest., 107, 1507-8 [PubMed].

Kassiotis G., Kollias G., 2001, "Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination", J. Exp. Med., 193, 427-434 [PubMed].

2000

Dumitru C. D., Ceci J. D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J. H., Patriotis C., Jenkins N. A., Copeland N. G., Kollias G., Tsichlis P. N., 2000, "TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway", Cell, 103, 1071-1083 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?", Arthritis Res., 2, 342-3 [PubMed].

Biedermann T., Kneilling M., Mailhammer R., Maier K., Sander C. A., Kollias G., Kunkel S. L., Hultner L., Rocken M., 2000, "Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2", J. Exp. Med., 192, 1441-52 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Accelerated autoimmunity and lupus nephritis in NZB mice with engineered heterozygous deficiency in tumor necrosis factor", Eur. J. Immunol., 30, 2038-47 [PubMed].

Schwarz E. M., Lu A. P., Goater J. J., Benz E. B., Kollias G., Rosier R. N., Puzas J. E., O'Keefe R. J., 2000, "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis", J. Orthop. Res., 18, 472-80 [PubMed].

Liefner M., Siebert H., Sachse T., Michel U., Kollias G., Bruck W., 2000, "The role of TNF-alpha during Wallerian degeneration", J. Neuroimmunol., 108, 147-52 [PubMed].

Abu-Amer Y., Erdmann J., Alexopoulou L., Kollias G., Ross F. P., Teitelbaum S. L., 2000, "Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis", J. Biol. Chem., 275, 27307-27310 [PubMed].

White D. W., Badovinac V. P., Kollias G., Harty J. T., 2000, "Cutting Edge: Antilisterial activity of CD8+T cells derived from TNF-deficient and TNF/perforin double-deficient mice", J. Immunol., 165, 5-9 [PubMed].

Pasparakis M., Kousteni S., Peschon J., Kollias G., 2000, "Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic precursors into splenic follicles", Cell. Immunol., 201, 33-41 [PubMed].

Goater J., Muller R., Kollias G., Firestein G. S., Sanz I., O'Keefe R. J., Schwarz E. M., 2000, "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis", J. Rheumatol., 27, 983-9 [PubMed].

Iyler S., Kontoyiannis D., Chevrier D., Woo J., Mori N., Cornejo M., Kollias G., Buelow R., 2000, "Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide", J. Biol. Chem., 275, 17051-7 [PubMed].

Mabbott N. A., Williams A., Farquhar C. F., Pasparakis M., Kollias G., Bruce M. E., 2000, "Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie", J. Virol., 74, 3338-44 [PubMed].

1999

Akassoglou K., Bauer J., Kassiotis G., Lassmann H., Kollias G., Probert L., 1999, "Transgenic models of TNF induced demyelination", Adv. Exp. Med. Biol., 468, 245-259 [PubMed].

Van den Berg W. B., Joosten L. A., Kollias G., and van De Loo F. A., 1999, "Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction", Ann. Rheum. Dis., 58 Suppl 1, I40-8 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Ann. Rheum. Dis., 58 Suppl 1, I32-9 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Immunol. Rev., 169, 175-194 [PubMed].

Glosli H., Veiby O. P., Fjerdingstad H., Mehlum A., Probert L., Kollias G., Gjernes E., Prydz H., 1999, "Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice", Eur. J. Haematol., 63, 50-60 [PubMed].

Moore R. J., Owens D. M., Stamp G., Arnott C., Burke F., East N., Holdsworth H., Turner L., Rollins B., Pasparakis M., Kollias G., Balkwill F., 1999, "Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis", Nat. Med., 5, 828-831 [PubMed].

Zhang Y., Pasparakis M., Kollias G., Simons M., 1999, "Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha", J. Biol. Chem., 274, 14786-14790 [PubMed].

Kontoyiannis D., Pasparakis M., Pizarro T. T., Cominelli F., Kollias G., 1999, "Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies", Immunity, 10, 387-398 [PubMed].

Kassiotis G., Bauer J., Akassoglou K., Lassmann H., Kollias G., Probert L., 1999, "A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice", Eur. J. Immunol., 29, 912-917 [PubMed].

Kassiotis G., Bauer J., Akassoglou K., Lassmann H., Kollias G., Probert L., 1999, "TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis", Eur. J. Immunol., 29:1, 774-780 [PubMed].

Neurath M. F., Hildner K., Becker C., Schlaak J. F., Barbulescu K., Germann T., Schmitt E., Schirmacher P., Haralambous S., Pasparakis M., Meyer Z. B. K., Kollias G., Marker-Hermann E., 1999, "Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression", Clin. Exp. Immunol., 115, 42-55 [PubMed].

Plows D., Kontogeorgos G., Kollias G., 1999, "Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen", J. Immunol., 162, 1018-1023 [PubMed].

1998

Adorini L., Bonneville M., Kollias G., 1998, "Pathogenic and protective T-cell responses in autoimmune diseases", Res. Immunol., 149, 873-875 [PubMed].

Tselios T., Probert L., Kollias G., Matsoukas E., Roumelioti P., Alexopoulos K., Moore G. J., Matsoukas J., 1998, "Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP)", Amino. Acids., 14, 333-341 [PubMed].

Maurer M., Echtenacher B., Hultner L., Kollias G., Mannel D. N., Langley K. E., Galli S. J., 1998, "The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells", J. Exp. Med., 188, 2343-2348 [PubMed].

Douni E., Kollias G., 1998, "A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF- R", J. Exp. Med., 188, 1343-1352 [PubMed].

Akassoglou K., Bauer J., Kassiotis G., Pasparakis M., Lassmann H., Kollias G., Probert L., 1998, "Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy", Am. J. Pathol., 153, 801-813 [PubMed].

Alexopoulou L., Pasparakis M., Kollias G., 1998, "Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function", J. Exp. Med., 188, 745-754 [PubMed].

Fiore M., Alleva E., Probert L., Kollias G., Angelucci F., Aloe L., 1998, "Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha", Physiol. Behav., 63, 571-576 [PubMed].

Bessis N., Chiocchia G., Kollias G., Minty A., Fournier C., Fradelizi D., Boissier M. C., 1998, "Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13", Clin. Exp. Immunol., 111, 391-396 [PubMed].

Alonzi T., Fattori E., Lazzaro D., Costa P., Probert L., Kollias G., De Benedetti F., Poli V., Ciliberto G., 1998, "Interleukin 6 is required for the development of collagen-induced arthritis", J. Exp. Med., 187, 461-468 [PubMed].

1997

Kusters S., Tiegs G., Alexopoulou L., Pasparakis M., Douni E., Kunstle G., Bluethmann H., Wendel A., Pfizenmaier K., Kollias G., Grell M., 1997, "In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis", Eur. J. Immunol., 27, 2870-2875 [PubMed].

Alexopoulou L., Pasparakis M., Kollias G., 1997, "A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling", Eur. J. Immunol., 27, 2588-2592 [PubMed].

Plumier J. C., Krueger A. M., Currie R. W., Kontoyiannis D., Kollias G., Pagoulatos G. N., 1997, "Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury", Cell Stress Chaperones, 2, 162-167 [PubMed].

Butler D. M., Malfait A. M., Mason L. J., Warden P. J., Kollias G., Maini R. N., Feldmann M., Brennan F. M., 1997, "DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition", J. Immunol., 159, 2867-2876 [PubMed].

Ventre J., Doebber T., Wu M., MacNaul K., Stevens K., Pasparakis M., Kollias G., Moller D. E., 1997, "Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice", Diabetes, 46, 1526-1531 [PubMed].

Neurath M. F., Fuss I., Pasparakis M., Alexopoulou L., Haralambous S., Meyer Z. B. K., Strober W., Kollias G., 1997, "Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice", Eur. J. Immunol., 27, 1743-1750 [PubMed].

Pasparakis M., Alexopoulou L., Grell M., Pfizenmaier K., Bluethmann H., Kollias G., 1997, "Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor", Proc. Natl. Acad. Sci. U.S.A., 94, 6319-6323 [PubMed].

Cope A. P., Liblau R. S., Yang X. D., Congia M., Laudanna C., Schreiber R. D., Probert L., Kollias G., McDevitt H. O., 1997, "Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling", J. Exp. Med., 185, 1573-1584 [PubMed].

Probert L., Akassoglou K., Kassiotis G., Pasparakis M., Alexopoulou L., Kollias G., 1997, "TNF-alpha transgenic and knockout models of CNS inflammation and degeneration", J. Neuroimmunol., 72, 137-141 [PubMed].

Akassoglou K., Probert L., Kontogeorgos G., Kollias G., 1997, "Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice", J. Immunol., 158, 438-445 [PubMed].

1996

Pasparakis M., Alexopoulou L., Douni E., Kollias G., 1996, "Tumour necrosis factors in immune regulation: everything that's interesting is...new!", Cytokine Growth Factor Rev., 7, 223-229 [PubMed].

Pasparakis M., Alexopoulou L., Episkopou V., Kollias G., 1996, "Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response", J. Exp. Med., 184, 1397-1411 [PubMed].

Fiore M., Probert L., Kollias G., Akassoglou K., Alleva E., Aloe L., 1996, "Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain", Brain Behav. Immun., 10, 126-138 [PubMed].

Georgopoulos S., Plows D., Kollias G., 1996, "Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice", J. Inflamm., 46, 86-97 [PubMed].

Probert L., Akassoglou K., Alexopoulou L., Douni E., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Kollias G., 1996, "Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice", J. Leukoc. Biol., 59, 518-525 [PubMed].

1995

Douni E., Akassoglou K., Alexopoulou L., Georgopoulos S., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Probert L., Kollias G., 1995, "Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis", J. Inflamm., 47, 27-38 [PubMed].

Grell M., Douni E., Wajant H., Lohden M., Clauss M., Maxeiner B., Georgopoulos S., Lesslauer W., Kollias G., Pfizenmaier K., 1995, "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor", Cell, 83, 793-802 [PubMed].

Plumier J. C., Ross B. M., Currie R. W., Angelidis C. E., Kazlaris H., Kollias G., Pagoulatos G. N., 1995, "Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery", J. Clin. Invest., 95, 1854-1860 [PubMed].

Probert L., Plows D., Kontogeorgos G., Kollias G., 1995, "The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice", Eur. J. Immunol., 25, 1794-1797 [PubMed].

Aloe L., Probert L., Kollias G., Micera A., Tirassa P., 1995, "Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice", Rheumatol. Int., 14, 249-252 [PubMed].

Siegel S. A., Shealy D. J., Nakada M. T., Le J., Woulfe D. S., Probert L., Kollias G., Ghrayeb J., Vilcek J., Daddona P. E., 1995, "The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo", Cytokine, 7, 15-25 [PubMed].

Probert L., Akassoglou K., Pasparakis M., Kontogeorgos G., Kollias G., 1995, "Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha", Proc. Natl. Acad. Sci. U.S.A., 92, 11294-11298 [PubMed].

1994

Taverne J., Sheikh N., de Souza J. B., Playfair J. H., Probert L., Kollias G., 1994, "Anaemia and resistance to malaria in transgenic mice expressing human tumour necrosis factor", Immunology, 82, 397-403 [PubMed].

1993

Grigoreas C., Pappas D., Galatas I. D., Kollias G., Papadimos S., Papadakis P., 1993, "Serum total IgE levels in a representative sample of a Greek population. I. Correlation with age, sex, and skin reactivity to common aeroallergens", Allergy, 48 (3), 142-146 [PubMed].

Probert L., Keffer J., Corbella P., Cazlaris H., Patsavoudi E., Stephens S., Kaslaris E., Kioussis D., Kollias G., 1993, "Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell- targeted human tumor necrosis factor transgenes", J. Immunol., 151, 1894-1906 [PubMed].

Kollias G., 1993, "Tumour necrosis factor: a specific trigger in arthritis", Res. Immunol., 144, 342-347 [PubMed].

Aloe L., Probert L., Kollias G., Bracci-Laudiero L., Spillantini M. G., Levi-Montalcini R., 1993, "The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor", Growth Factors, 9, 149-155 [PubMed].

Aloe L., Probert L., Kollias G., Bracci-Laudiero L., Micera A., Mollinari C., Levi-Montalcini R., 1993, "Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice", Int. J. Tissue React., 15, 139-143 [PubMed].

1991

Keffer J., Probert L., Cazlaris H., Georgopoulos S., Kaslaris E., Kioussis D., Kollias G., 1991, "Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis", EMBO J., 10, 4025-4031 [PubMed].

Dillon N., Kollias G., Grosveld F., Williams J. G., 1991, "Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice", Nucleic. Acids. Res., 19, 6227-6230 [PubMed].

1988

Grosveld F., Kollias G., 1988, "Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities", Cell, 54, 920 [PubMed].

1987

Grosveld F., van Assendelft G. B., Greaves D. R., Kollias G., 1987, "Position-independent, high-level expression of the human beta-globin gene in transgenic mice", Cell, 51, 975-985 [PubMed].

Grosveld F., Antoniou M., van Assendelft G. B., de Boer E., Hurst J., Kollias G., MacFarlane F., Wrighton N., 1987, "The regulation of expression of human beta-globin genes", Prog. Clin. Biol. Res., 251, 133-144 [PubMed].

Kollias G., Hurst J., deBoer E., Grosveld F., 1987, "The human beta-globin gene contains a downstream developmental specific enhancer", Nucleic. Acids. Res., 15, 5739-5747 [PubMed].

Kollias G., Evans D. J., Ritter M., Beech J., Morris R., Grosveld F., 1987, "Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities", Cell, 51, 21-31 [PubMed].

Kollias G., Spanopoulou E., Grosveld F., Ritter M., Beech J., Morris R., 1987, "Differential regulation of a Thy-1 gene in transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 84, 1492-1496 [PubMed].

1986

Kollias G., Wrighton N., Hurst J., Grosveld F., 1986, "Regulated expression of human A gamma-, beta-, and hybrid gamma beta- globin genes in transgenic mice: manipulation of the developmental expression patterns", Cell, 46, 89-94 [PubMed].

Kolsto A. B., Kollias G., Giguere V., Isobe K. I., Prydz H., Grosveld F., 1986, "The maintenance of methylation-free islands in transgenic mice", Nucleic. Acids. Res., 14, 9667-9678 [PubMed].

Isobe K., Kollias G., Kolsto A. B., Grosveld F., 1986, "T cell independent Thy-1 allo-antibody response with the use of transgenic mice", J. Immunol., 137, 2089-2092 [PubMed].

1985

Kollias G., Sekeris C. E., Grosveld F. G., 1985, "Alpha-amanitin insensitive transcription of the human epsilon-globin gene", Nucleic. Acids. Res., 13, 7993-8005 [PubMed].