Publications

Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E. 2017, "Novel insights into SLC25A46-related pathologies in a genetic mouse model", PLoS Genet, Apr 4;13(4): e1006656. doi: 10.1371 [PubMed].

Llop-Guevara A, Porras M, Cendón C, Di Ceglie I, Siracusa F, Madarena F, Rinotas V, Gómez L, van Lent PL, Douni E, Chang HD, Kamradt T, Román J. 2015, "Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice", Arthritis Res Ther, 17:356. [PubMed].

Papaneophytou C, Alexiou P, Papakyriakou A, Ntougkos E, Tsiliouka K, Maranti A, Liepouri F, Strongilos A, Mettou A, Couladouros E, Eliopoulos E, Douni E, Kollias G, Kontopidis G. 2015, "Synthesis and biological evaluation of potential small molecule inhibitors of tumor necrosis factor", Med. Chem. Commun, 6 : 1196-1209. [PubMed].

Agas D, Marchetti L, Douni E, Sabbieti MG. 2015, "The unbearable lightness of bone marrow homeostasis", Cytokine & Growth Factor Reviews, 26(3) :347-59 [PubMed].

Alexiou P, Papakyriakou A, Ntougkos E, Papaneophytou CP, Liepouri F, Mettou A, Katsoulis I, Maranti A, Tsiliouka K, Strongilos A, Chaitidou S, Douni E, Kontopidis G, Kollias G, Couladouros E, Eliopoulos E. 2014, "Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects", Arch Pharm, 347(11): 798-805 [PubMed].

Ioakeimidis F, Ott C, Kozjak-Pavlovic V, Violitzi F, Rinotas V, Makrinou E, Eliopoulos E, Fasseas C Kollias G, Douni E. 2014, "A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice", PLoS One, 9(8) :e104237 [PubMed].

Perperopoulou FD, Tsoungas PG, Thireou TN, Rinotas VE, Douni EK, Eliopoulos EE, Labrou NE, Clonis YD. 2014, "2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1", Bioorganic and Medicinal Chemistry, 22(15) :3957-70 [PubMed].

Rinotas V, Niti A, Dacquin R, Bonnet N, Stolina M, Han CY, Kostenuik P, Jurdic P, Ferrari S, Douni E. 2014, "Novel genetic models of osteoporosis by overexpression of human RANKL in transgenic mice", J Bone Miner Res. , 29(5) :1158-69 [PubMed].

Zoi OG, Thireou TN, Rinotas VE, Tsoungas PG, Eliopoulos EE Douni EK, Labrou NE, Clonis YD 2013, "Designer Xanthone: An Inhibitor Scaffold for MDR-Involved Human Glutathione Transferase Isoenzyme A1-1", J Biomol Screen, , 2013 Oct; 18(9):1092-102. [PubMed].

Papaneophytou CP, Rinotas V, Douni E, Kontopidis G. 2013, "A statistical approach for optimization of RANKL overexpression in Escherichia coli: Purification and characterization of the protein", Protein Expr Purif, , 2013 Jul; 90(1):9-19 [PubMed].

Bonaparte D, Cinelli P, Douni E, Hérault Y, Maas A, Pakarinen P, Poutanen M, Lafuente MS, Scavizzi F 2013, "FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group", Lab Anim, , 2013 Jul; 47(3):134-45. [PubMed].

Papaneophytou CP, Mettou AK, Rinotas V, Douni E, Kondopidis GA. 2013, "Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study", ACS Med. Chem. Lett; , 4 (1):137–141. [PubMed].

Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G. 2012, "A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.", Hum Mol Genet. , 2012 Feb 15. 21(4):784-98. [PubMed].

Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium , de Angelis MH, Brown SD, Hancock JM, Mallon AM., 2010, "EuroPhenome: a repository for high-throughput mouse phenotyping data.", Nucleic Acids Res, 2010 Jan;38(Database issue):, D577-85. Epub 2009 Nov 23.; [PubMed].

Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P. 2009, "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.", Arthritis Res Ther., 2009 Sep 18;11(5):R138. [Epub ahead of print] , [PubMed]

Douni E,Armaka M, Kontoyiannis DL, Kollias G 2007, "Functional genetic and genomic analysis of modeled arthritis.", Adv Exp Med Biol. , 2007; , 602:33-42 [PubMed].

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M Douni E, Kontoyiannis DL, Zouberakis M, Kollias G; Mugen NoE consortium 2007, "MUGEN mouse database; animal models of human immunological diseases.", Nucleic Acids Res. , 2008 Jan;36(Database issue) , D1048-54. Epub 2007 Oct 11. [PubMed].

Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A Douni E, Blackshear PJ, Kontoyiannis DL, Kollias G. 2006, "Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.", Eur J Immunol. , 2006 Oct;36(10) , 2768-80. [PubMed].

Thwin MM, Douni E, Aidinis V, Kollias G, Kodama K, Sato K, Satish RL, Mahendran R, Gopalakrishnakone P. 2004, "Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study.", Arthritis Res Ther. , 2004;6(3) , R282-94. Epub 2004 Apr 28 [PubMed].

Douni E, Alexiou M, Kollias G. 2004, "Genetic engineering in the mouse: tuning TNF/TNFR expression.", Methods Mol Med. , 2004;98: , 137-70 [PubMed].

Douni E, Sfikakis PP, Haralambous S, Fernandes P, Kollias G. 2004, "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols.", Arthritis Res Ther. , 2004;6(1) , :R65-R72. Epub 2003 Nov 7. [PubMed].

Holtmann MH, Douni E, Schütz M, Zeller G, Mudter J, Lehr HA, Gerspach J, Scheurich P, Galle PR, Kollias G, Neurath MF. 2002, "Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo.", Eur J Immunol. , 2002 Nov;32(11) , :3142-51 [PubMed].

Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L. 2003, "Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.", Proc Natl Acad Sci U S A. , 2003 Jan 21;100(2), :709-14. Epub 2003 Jan 9. [PubMed].

Kollias G, Kontoyiannis D, Douni E, Kassiotis G. 2002, "The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies.", Curr Dir Autoimmun. , 2002;5: , 30-50 [PubMed].

Kollias G, Douni E, Kassiotis G, Kontoyiannis D. 1999, "The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.", Ann Rheum Dis , 1999 Nov; , 58 Suppl 1:I32-9 [PubMed].

Kollias G, Douni E, Kassiotis G, Kontoyiannis D. 1999, "On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.", Immunol Rev. , 1999 Jun; , 169:175-94 [PubMed].

Douni E, Kollias G. 1998, "A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.", J Exp Med. , 1998 Oct 5; , 188(7):1343-52. [PubMed].

Küsters S, Tiegs G, Alexopoulou L, Pasparakis M, Douni E, Künstle G, Bluethmann H, Wendel A, Pfizenmaier K, Kollias G, Grell M. 1997, "In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.", Eur J Immunol.; , 1997 Nov , 27(11):2870-5. [PubMed].

Pasparakis M, Alexopoulou L, Douni E, Kollias G. 1996, "Tumour necrosis factors in immune regulation: everything that's interesting is...new!", Cytokine Growth Factor Rev. ; , 1996 Oct , 7(3):223-9. [PubMed].

Probert L, Akassoglou K, Alexopoulou L, Douni E, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Kollias G. 1996, "Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.", J Leukoc Biol. , 1996 Apr; , 59(4):518-25 [PubMed].

Grell M, Douni E, Wajant H, Löhden M, Clauss M, Maxeiner B, Georgopoulos S, Lesslauer W, Kollias G, Pfizenmaier K, Scheurich P. 1995, "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.", Cell , 1995 Dec 1;, 83(5):793-802 [PubMed].

Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Probert L, Kollias G. 1995, "Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.", J Inflamm. , 1995-1996; , 47(1-2):27-38 [PubMed].

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