Efthimios Skoulakis Research Group

2024

Zerva MC, Triantafylloudis C, Paspaliaris V, Skoulakis EMC, Papanikolopoulou K. 2024, "Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila.", Cells., 2024 Apr 25; 13(9):746. doi: 10.3390/cells13090746. [PubMed].

Atsoniou K, Giannopoulou E, Georganta EM, Skoulakis EMC. 2024, "Drosophila Contributions towards Understanding Neurofibromatosis 1.", Cells., 2024 Apr 21; 13(8):721. doi: 10.3390/cells13080721. [PubMed].

2023

Ergina Vourkou, Eva D Rouiz Ortega, Sumeet Mahajan, Amrit Mudher, Efthimios M C Skoulakis. 2023, "Human Tau Aggregates Are Permissive to Protein Synthesis-Dependent Memory in Drosophila Tauopathy Models", J Neurosci., 2023 Apr 19; 43(16):2988-3006. doi: 10.1523/JNEUROSCI.1374-22.2023. Epub 2023 Mar 3. [PubMed].

2022

Vourkou E, Paspaliaris V, Bourouliti A, Zerva MC, Prifti E, Papanikolopoulou K, Skoulakis EMC. 2022, "Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS", Int J Mol Sci., 2022 Oct 26;23(21):12985. doi: 10.3390/ijms232112985. [PubMed].

Foka K, Georganta EM, Semelidou O, Skoulakis EMC. 2022, "Loss of the Schizophrenia-linked Furin protein from Drosophila mushroom body neurons results in antipsychotic-reversible habituation deficits.", J Neurosci., 2022 Aug 25; 42(39):7496-511. [PubMed].

Bourouliti A, Skoulakis EMC. 2022, "Anesthesia Resistant Memories in Drosophila, a Working Perspective.", Int J Mol Sci., 2022 Jul 31;, 23(15):8527. doi: 10.3390/ijms23158527 [PubMed].

Bourouliti A, Skoulakis EMC. 2022, "Cold Shock Disrupts Massed Training-Elicited Memory in Drosophila.", Int J Mol Sci., 2022 Jun 8;, 23(12):6407. doi: 10.3390/ijms23126407 [PubMed].

Galanis A, Vardakas P, Reczko M, Harokopos V, Hatzis P, Skoulakis EMC, Pavlopoulos GA, Patalano S. 2022, "Bee foraging preferences, microbiota and pathogens revealed by direct shotgun metagenomics of honey.", Mol Ecol Resour., 2022 May 20. , doi: 10.1111/1755-0998.13626. Online ahead of print [PubMed].

Prifti E, Tsakiri EN, Vourkou E, Stamatakis G, Samiotaki M, Skoulakis EMC, Papanikolopoulou K. 2022, "Mical modulates Tau toxicity via cysteine oxidation in vivo.", Acta Neuropathol Commun., 2022 Apr 4;, 10(1):44. doi: 10.1186/s40478-022-01348-1 [PubMed].

2021

Kosmidis S, Denny CA, Dranovsky A, Skoulakis EMC. 2021, "Editorial: Molecular and Cellular Underpinnings of Age-Related Memory Loss.", Front Cell Dev Biol., 2021 Aug 20;, 9:743187. doi: 10.3389/fcell.2021.743187. eCollection 2021. [PubMed].

Georganta EM, Moressis A, Skoulakis EMC. 2021, " Associative Learning Requires Neurofibromin to Modulate GABAergic Inputs to Drosophila Mushroom Bodies", J Neurosci., 2021 Jun 16;41(24):5274-5286. doi: 10.1523/JNEUROSCI.1605-20.2021. Epub 2021 May 10 [PubMed].

2020

Keramidis I, Vourkou E, Papanikolopoulou K, Skoulakis EMC. 2020, "Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster.", Front Mol Neurosci. , 2020 Oct 21; 13:569520. [PubMed].

Semelidou O, Skoulakis EMC. 2020, "One size does not fit all in Drosophila olfactory habituation", Proc Natl Acad Sci U S A. , 2020 Aug 25; 117(34):20372. doi: 10.1073/pnas.2012622117 [PubMed].

Papanikolopoulou K, Skoulakis EMC. 2020, "Altered Proteostasis in Neurodegenerative Tauopathies", Adv Exp Med Biol., 2020;1233: 177-194. doi: 10.1007/978-3-030-38266-7_7. Review. [PubMed].

2019

Roussou IG, Papanikolopoulou K, Savakis C, Skoulakis EMC. 2019, "Drosophila Bruton's Tyrosine Kinase Regulates Habituation Latency and Facilitation in Distinct Mushroom Body Neurons.", J Neurosci., 2019 Oct 30; 39(44):8730-8743 [PubMed].

Katerina Papanikolopoulou, Jean Gouzi, Ilianna Roussou, Martina Samiotaki and Efthimios Skoulakis 2019, "Drosophila Tau negatively regulates translation and olfactory Long-Term Memory, but facilitates footshock habituation and cytoskeletal homeostasis", Journal of Neuroscience. , 39, 8315-8329 [PubMed].

Tzortzopoulos A, Thomaidou D, Gaitanou M, Matsas R, Skoulakis E. 2019, "Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation", Neurosci Bull., 2019 May 11. doi: 10.1007/s12264-019-00386-5. [Epub ahead of print] [PubMed].

Papanikolopoulou K, Mudher A, Skoulakis E. 2019, "An assessment of the translational relevance of Drosophila in drug discovery.", Expert Opin Drug Discov, 2019 Jan 21: 1-11. doi: 10.1080/17460441.2019.1569624. [Epub ahead of print] [PubMed].

2018

Semelidou O, Acevedo SF, Skoulakis EM. 2018, "Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation in Drosophila", Elife. , 2018 Dec 21; 7. pii: e39569. doi: 10.7554/eLife.39569. [PubMed].

Kadas D, Papanikolopoulou K, Xirou S, Consoulas C, Skoulakis EMC. 2018, "Human Tau isoform-specific presynaptic deficits in a Drosophila Central Nervous System circuit", Neurobiol Dis., 2018 Dec 8; 124:311-321. doi: 10.1016/j.nbd.2018.12.004 [PubMed].

Crittenden JR, Skoulakis EMC, Goldstein ES, Davis RL. 2018, "Drosophila mef2 is essential for normal mushroom body and wing development.", Biol Open, 2018 Aug 16. pii: bio.035618. doi: 10.1242/bio.035618. [Epub ahead of print] [PubMed].

Gouzi JY, Bouraimi M, Roussou IG, Moressis A, Skoulakis EMC. 2018, "The Drosophila Receptor Tyrosine Kinase Alk Constrains Long-term Memory Formation", JNeurosci., 2018 Aug 29. 38(35):7701-7712. doi: 10.1523/JNEUROSCI.0784-18.2018. Epub 2018 Jul 20. [PubMed].

Turin L, Skoulakis EMC. 2018, "Electron Spin Resonance (EPR) in Drosophila and General Anesthesia.", Methods Enzymol. , 2018;603: 115-128. doi: 10.1016/bs.mie.2018.01.020. Epub 2018 Mar 8. [PubMed].

Papanikolopoulou K, Grammenoudi S, Samiotaki M, Skoulakis EMC. 2018, "Differential effects of 14-3-3 dimers on Tau phosphorylation, stability and toxicity in vivo.", Hum Mol Genet. , 2018 Apr 12. doi: 10.1093/hmg/ddy129. [Epub ahead of print] [PubMed].

2017

Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, Buee L. 2017, "Atypical, non-standard functions of the microtubule associated Tau protein", Acta Neuropathol Commun., 2017 Nov 29; 5(1):91. doi: 10.1186/s40478-017-0489-6. [PubMed].

Maniati K, Haralambous KJ, Turin L, Skoulakis EMC. 2017, "Vibrational Detection of Odorant Functional Groups by Drosophila melanogaster", eNeuro, 2017 Oct 31; 4(5). pii: ENEURO.0049-17.2017. doi: 10.1523/ENEURO.0049-17.2017. eCollection 2017 Sep-Oct. [PubMed].

Kotoula V, Moressis A, Semelidou O, Skoulakis EMC. 2017, "Drk-mediated signaling to Rho kinase is required for anesthesia-resistant memory in Drosophila", Proc Natl Acad Sci U S A. , 2017 Oct 10; 114(41):10984-10989. doi: 10.1073/pnas.1704835114. Epub 2017 Sep 25. [PubMed].

Mansilla A, Chaves-Sanjuán A, Campillo N E, Semelidou O, Martínez-González L, Infantes L, González-Rubio J M, Gil C, Conde S, Skoulakis EMC, Ferrús A, Martínez A, Sánchez-Barrena M J. 2017, "Phenothiazines regulate synaptic function by interfering the NCS-1/Ric8a complex: a novel approach for Fragile X Syndrome", Proc Natl Acad Sci U S A, 114(6) :E999-E1008. doi: 10.1073/pnas.1611089114 [PubMed].

Sealey MA, Vourkou E, Cowan CM, Bossing T, Quraishe S, Grammenoudi S, Skoulakis EMC, Mudher A. 2017, "Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy.", Neurobiol Dis. , 2017 May 11; 105:74-83. doi: 10.1016/j.nbd.2017.05.003. [Epub ahead of print] [PubMed].

Paoli M, Münch D, Haase A, Skoulakis EMC, Turin L, Galizia CG. 2017, "Minute Impurities Contribute Significantly to Olfactory Receptor Ligand Studies: Tales from Testing the Vibration Theory", eNeuro. , 2017 Jun 19; 4(3). pii: ENEURO.0070-17.2017. doi: 10.1523/ENEURO.0070-17.2017. eCollection 2017 May-Jun. [PubMed].

2016

Drimyli E, Gaitanidis A, Maniati K, Turin L, Skoulakis EM. 2016, "Differential Electrophysiological Responses to Odorant Isotopologues in Drosophilid Antennae.", eNeuro., 2016 Jun 20; 3(3). pii: ENEURO.0152-15.2016. doi: 10.1523/ENEURO.0152-15.2016. [PubMed].

2015

Turin L, Gane S, Georganakis D, Maniati K, Skoulakis EM. 2015, "Plausibility of the vibrational theory of olfaction", Proc Natl Acad Sci U S A. , 2015 Jun 23; 112(25):E3154. doi: 10.1073/pnas.1508035112. Epub 2015 Jun 4 [PubMed].

Papanikolopoulou K, Skoulakis EM. 2015, "Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila.", Hum Mol Genet. , 2015 Apr 1; 24(7):2065-77. doi: 10.1093/hmg/ddu726. Epub 2014 Dec 18 [PubMed].

2014

Kosmidis S, Missirlis F, Botella JA, Schneuwly S, Rouault TA, Skoulakis EM. 2014, "Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.", Front Pharmacol. , 2014 Apr 4; 5:66. doi: 10.3389/fphar.2014.00066. eCollection 2014 [PubMed].

Turin L, Skoulakis EM, Horsfield AP. 2014, "Electron spin changes during general anesthesia in Drosophila.", Proc Natl Acad Sci U S A. , 2014 Aug 26; 111(34):E3524-33. doi: 10.1073/pnas.1404387111. Epub 2014 Aug 11. [PubMed].

Kosmidis S, Missirlis F, Botella JA, Schneuwly S, Rouault TA, Skoulakis EM. 2014, "Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.", Front Pharmacol, 2014 Apr 4;5:66. doi: 10.3389/fphar.2014.00066. eCollection 2014 [PubMed].

2013

Lalle M, Leptourgidou F, Camerini S, Pozio E, Skoulakis EMC . 2013, "Interkingdom Complementation Reveals Structural Conservation and Functional Divergence of 14-3-3 Proteins.", PLoS ONE , 8(10): e78090. doi:10.1371/journal.pone.0078090 [Pubmed].

Gane S, Georganakis D, Maniati K, Vamvakias M, Ragoussis N, Skoulakis EM . and Turin,L. 2013, "Molecular Vibration-Sensing Component in Human Olfaction.", PLoS ONE , 8(1):e55780. 0 doi:10.1371/journal.pone.005578 [PLOS].

2012

Kanellopoulos AK, Semelidou O, Kotini AG, Anezaki M, Skoulakis EM . 2012, "Learning and memory deficits consequent to reduction of the fragile x mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.", J Neurosci. , 2012 Sep 19; 32(38):13111-24. [PubMed].

Skoulakis EM , Mudher A 2012, "Twice is better: highlights of the second meeting focused on tau biology and pathology.", Biochem Soc Trans. , 2012 Aug 1; 40(4):641-3. [PubMed].

Morales D, Skoulakis EC , Acevedo SF. 2012, "14-3-3s are potential biomarkers for HIV-related neurodegeneration.", J Neurovirol. , 2012 Jul 19. [Epub ahead of print] [PubMed].

Tsigkari KK, Acevedo SF, Skoulakis EM . 2012, "14-3-3ε is required for germ cell migration in Drosophila.", PLoS One. , 2012; , 7(5):e36702. Epub 2012 May 30. [PubMed].

Kadas D, Tzortzopoulos A, Skoulakis EM , Consoulas C. 2012, "Constitutive Activation of Ca2+/Calmodulin-Dependent Protein Kinase II during Development Impairs Central Cholinergic Transmission in a Circuit Underlying Escape Behavior in Drosophila.", J Neurosci. , 2012 Jan 4; , 32(1):170-82. [PubMed].

2011

Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, et al . 2011, "The Receptor Tyrosine Kinase Alk Controls Neurofibromin Functions in Drosophila Growth and Learning.", PLoS Genet , 7(9): e1002281. doi:10.1371/journal.pgen.1002281 [Plos Genetics].

Papanikolopoulou K, Skoulakis EM. 2011, "The Power and Richness of Modelling Tauopathies in Drosophila.", Mol Neurobiol. , 2011 Jun 17. [Epub ahead of print] [PubMed].

Shandala T, Woodcock JM, Ng Y, Biggs L, Skoulakis EM, Brooks DA, Lopez AF. 2011, "Drosophila 14-3-3{varepsilon} has a crucial role in anti-microbial peptide secretion and innate immunity.", J Cell Sci. , 2011 Jul 1; 124(Pt 13):2165-74. [PubMed].

Memos N, Kataki A, Chatziganni E, Nikolopoulou M, Skoulakis EM, Consoulas C, Zografos G, Konstadoulakis M. 2011, "Alternations of 14-3-3 θ and β protein levels in brain during experimental sepsis.", J Neurosci Res. , 2011 May 26. doi: 10.1002/jnr.22673. [Epub ahead of print] [PubMed].

Kosmidis S, Botella JA, Mandilaras K, Schneuwly S, Skoulakis EM, Rouault TA, Missirlis F. 2011, "Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.", Neurobiol Dis. , 2011 Jul; 43(1):213-9. Epub 2011 Apr 1. [PubMed].

Franco MI, Turin L, Mershin A, Skoulakis EM. 2011, "Molecular vibration-sensing component in Drosophila melanogaster olfaction.", Proc Natl Acad Sci U S A. , 2011 Mar 1;108(9) :3797-802. Epub 2011 Feb 14. [PubMed].

2010

Papanikolopoulou K, Kosmidis S, Grammenoudi S, Skoulakis EM. 2010, "Phosphorylation differentiates tau-dependent neuronal toxicity and dysfunction.", Biochem Soc Trans., 2010 Aug 1;38(4):, 981-7; [PubMed].

Skoulakis EM, Mudher A. 2010, "Two days of tau: a meeting focused on its biology and pathology.", Biochem Soc Trans, 2010 Aug 1;38(4):, 953-4; [PubMed].

Kosmidis S, Grammenoudi S, Papanikolopoulou K, Skoulakis EM. 2010, "Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.", J Neurosci., 2010 Jan 13;30(2):, 464-77.; [PubMed].

2009

Messaritou G, Grammenoudi, S and Skoulakis EMC, 2009, "Dimerization is essential for Drosophila 14-3-3ζ protein stability and function in vivo", J. Biol. Chem, doi/10.1074/jbc.M109.045989, [JBC]

Messaritou G, Leptourgidou F. Franco, M and Skoulakis EMC, 2009, "A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14-3-3ζ gene", FEBS, Lett. 583: 2934-2938., [PubMed]

Anastasios Moressis, Anke R. Friedrich, Elias Pavlopoulos, Ronald L. Davis Efthimios M. C. Skoulakis, 2009, "A Dual Role for the Adaptor Protein DRK in Drosophila Olfactory Learning and Memory .", J. Neurosci. , 2009 29: 2611-2625., [PubMed]

2008

Pavlopoulos E, Anezaki M, Skoulakis EM, 2008, "Neuralized is expressed in the {alpha}/{beta} lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation..", Proc Natl Acad Sci U S A. , 2008 Sep 15.[Epub ahead of print], [PubMed].

Grammenoudi S, Anezaki M, Kosmidis S, Skoulakis EM. , 2008, "Modelling cell and isoform type specificity of tauopathies in Drosophila.", SEB Exp Biol Ser. , 2008;60, 39-56 [PubMed - in process]

2007

Tzortzopoulos A, Skoulakis EM. , 2007, "Paternally and maternally transmitted GAL4 transcripts contribute to UAS transgene expression in early Drosophila embryos.", Genesis , 2007 Dec;45, (12):737-43 [PubMed - in process]

Acevedo SF, Tsigkari KK, Grammenoudi S, Skoulakis E. , 2007, "In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins.", Genetics , 2007 Sep;177, (1):239-53 Epub 2007 Jul 29. [PubMed - in process]

Missirlis F, Kosmidis S, Brody T, Mavrakis M, Holmberg S, Odenwald WF, Skoulakis E. Rouault TA. , 2007, "Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin.", Genetics , 2007 Sep;177, (1):89-100 Epub 2007 Jul 1. [PubMed - in process]

Tsichritzis T, Gaentzsch PC, Kosmidis S, Brown AE, Skoulakis E. Ligoxygakis P, Mosialos G. , 2007, "A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.", Development , 2007 Jul;134, (14):2605-14 Epub 2007 Jun 6. [PubMed - in process]

Summer F. Acevedo, Emmanuil I. Froudarakis, Alexandros Kanellopoulos Skoulakis E. , 2007, "Protection from premature habituation requires functional mushroom bodies in Drosophila.", Learn. Mem. , 2007, 14: 376-384 [].

2006

Acevedo SF, Froudarakis EI, Tsiorva AA, Skoulakis E. , 2006, "Distinct neuronal circuits mediate experience-dependent, non-associative osmotactic responses in Drosophila.", Mol Cell Neurosci., 2006 Dec 29, [Epub ahead of print] [PubMed].

Grammenoudi S. ,Kosmidis S. ,Skoulakis E. , 2006, "Cell type-specific processing of human Tau proteins in Drosophila.", FEBS Letter., Volume 580, Issue 19, 4602-4606. [PubMed].

Skoulakis E. ,Grammenoudi S., 2006, "Dunces and da Vincis: the genetics of learning and memory in Drosophila", Cell Mol Life Sci., 2006 May, 63(9):975-88. [PubMed].

2004

Mershin A., Pavlopoulos E., Fitch O., Braden B. C., Nanopoulos D. V., Skoulakis E., 2004, "Learning and memory deficits upon TAU accumulation of in Drosophila mushroom body neurons", Learning and Memory, 11, 277-287 [PubMed].

2003

Chen H.-K., Fernandez-Funez P., Lam Y. C., Kaytor M. D., Fernandez M. H., Acevedo S. F., Aitken A., Skoulakis E., Orr H. T., Botas J., Zoghbi H. Y., 2003, "Akt phosphorylation-dependent association of ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1", Cell, 113, 457-468 [PubMed].

Sathyanarayana P., Barthwal M. K., Lane M. E., Acevedo S. F., Skoulakis E., Bergman A., Rana A., 2003, "Drosophila Mixed Lineage Kinase, a missing biochemical Link in Drosophila JNK signaling", Biochem. Biophys. Acta, 1640, 77-84 [PubMed].

2001

Philip N., Acevedo S., Skoulakis E., 2001, "Conditional rescue of olfactory learning and memory defects in mutants of the 14-3-3z gene leonardo", J. Neurosci., 21, 8417-8425 [PubMed].

1999

Nanopoulos D. V., Mershin A., Skoulakis E., 1999, "Quantum Brain?", Proc. Acad. Athens, Greece, 74, 148-179.

1998

Crittenden J. R., Skoulakis E., Han K.-A., Kalderon D., Davis R. L., 1998, "Tripartite Mushroom Body architecture revealed by antigenic markers", Learning and Memory, 5, 38-51 [PubMed].

Skoulakis E., Davis R. L., 1998, "14-3-3 proteins in Neuronal development and Function", Molecular Neurobiology, 16, 269-284 [PubMed].

1997

Li W., Skoulakis E., Davis R. L., Perrimon N., 1997, "The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras1-dependent manner", Development, 124, 4163-4171 [PubMed].

Broadie K., Rushton E., Skoulakis E., Davis R. L., 1997, "Leonardo, a Drosophila 14-3-3 protein involved in Learning regulates presynaptic function", Neuron, 19, 391-402 [PubMed].

1996

Skoulakis E., Davis R. L., 1996, "Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-3-3 protein", Neuron, 17, 931-944 [PubMed].

1995

Davis R. L., Cherry J., Dauwalder B., Han P. L., Skoulakis E., 1995, "The Cyclic AMP System and Drosophila Learning", Molecular and Cellular Biochemistry, 49/150, 271-278 [PubMed].

1993

Skoulakis E., Kalderon D., Davis R. L., 1993, "Preferential Expression in Mushroom Bodies of the Catalytic Subunit of Protein Kinase A and its Role in Learning and Memory", Neuron, 11, 197-208 [PubMed].

Bolwig G., Chromey C., Crittenden J., Dauwalder B., DeZazzo J., Han K. A., Han P. L., Nighorn A., Qiu Y. H., Skoulakis E., West R., Davis R. L., 1993, "Gene expression and learning in Drosophila", J. Cell. Biochemistry, 17D, 246.

1991

Leicht B., Skoulakis E., Sites C., Lyckegaard E., Clark A., 1991, "Identification of cis-regulatory elements involved in alternative splicing of the MLK-ALK pre-messenger-RNA of Drosophila", Am. J. Human Genetics, 49, 430.