Publications

2023

Stylianaki EA, Magkrioti C, Ladopoulou EM, Papavasileiou KD, Lagarias P, Melagraki G, Samiotaki M, Panayotou G, Dedos SG, Afantitis A, Aidinis V, Matralis AN. 2023, ""Hit" to lead optimization and chemoinformatic studies for a new series of Autotaxin inhibitors.", Eur J Med Chem., 2023 Mar 5; 249:115130. doi: 10.1016/j.ejmech.2023.115130. Epub 2023 Jan 23. [PubMed].

Karkali K, Saunders TE, Panayotou G, Martín-Blanco E. 2023, "JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos.", Nat Commun., 2023 Feb 7; 14(1):675. doi: 10.1038/s41467-023-36388-1. [PubMed].

Gomes PA, Bodo C, Nogueras-Ortiz C, Samiotaki M, Chen M, Soares-Cunha C, Silva JM, Coimbra B, Stamatakis G, Santos L, Panayotou G, Tzouanou F, Waites CL, Gatsogiannis C, Sousa N, Kapogiannis D, Costa-Silva B, Sotiropoulos I. 2023, "A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology.", Cell Commun Signal., 2023 Feb 13; 21(1):35. doi: 10.1186/s12964-023-01045-z. [PubMed].

Papadopoulos G, Legaki AI, Georgila K, Vorkas P, Giannousi E, Stamatakis G, Moustakas II, Petrocheilou M, Pyrina I, Gercken B, Kassi E, Chavakis T, Pateras IS, Panayotou G, Gika H, Samiotaki M, Eliopoulos AG, Chatzigeorgiou A. 2023, "Integrated omics analysis for characterization of the contribution of high fructose corn syrup to non-alcoholic fatty liver disease in obesity.", Metabolism., 2023 Mar 28: 155552. doi: 10.1016/j.metabol.2023.155552. Online ahead of print. [PubMed].

2022

Taze C, Drakouli S, Samiotaki M, Panayotou G, Simos G, Georgatsou E, Mylonis I. 2022, "Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling.", Redox Biol., 2022 Nov 17; 58:102545. doi: 10.1016/j.redox.2022.102545. Online ahead of print. [PubMed].

Georgiou-Siafis SK, Samiotaki MK, Demopoulos VJ, Panayotou G, Tsiftsoglou AS. 2022, "Glutathione-Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells' Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis.", Antioxidants (Basel)., 2022 Sep 30; 11(10):1959. doi: 10.3390/antiox11101959 [PubMed].

Armakolas A, Dimopoulou V, Nezos A, Stamatakis G, Samiotaki M, Panayotou G, Tampaki M, Stathaki M, Dourakis S, Koskinas J. 2022, "Cellular, Molecular and Proteomic Characteristics of Early Hepatocellular Carcinoma.", Curr Issues Mol Biol. , 2022 Oct 10; 44(10):4714-4734. doi: 10.3390/cimb44100322 [PubMed].

Temponeras I, Stamatakis G, Samiotaki M, Georgiadis D, Pratsinis H, Panayotou G, Stratikos E. 2022, "ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides.", Int J Mol Sci. , 2022 Feb 8; 23(3):1913. doi: 10.3390/ijms23031913 [PubMed].

Antoniou N, Prodromidou K, Kouroupi G, Boumpoureka I, Samiotaki M, Panayotou G, Xilouri M, Kloukina I, Stefanis L, Grailhe R, Taoufik E, Matsas R. 2022, "High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease.", NPJ Parkinsons Dis., 2022 Feb 11; 8(1):15. doi: 10.1038/s41531-022-00278-y. [PubMed].

Karra AG, Sioutopoulou A, Gorgogietas V, Samiotaki M, Panayotou G, Psarra AG. 2022, "Proteomic analysis of the mitochondrial glucocorticoid receptor interacting proteins reveals pyruvate dehydrogenase and mitochondrial 60 kDa heat shock protein as potent binding partners.", J Proteomics., 2022 Apr 15; 257:104509. doi: 10.1016/j.jprot.2022.104509. Epub 2022 Feb 4. [PubMed].

Chandris P, Giannouli CC, Panayotou G, . 2022, "Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters.", Front Cell Dev Biol., 2022 Jan 18; 9:725114. doi: 10.3389/fcell.2021.725114. eCollection 2021. [PubMed].

Vasiliki-Iris Perivolidi, Foteini Violitzi, Elisavet Ioannidou, Vagelis Rinotas, George Stamatakis, Martina Samiotaki, George Panayotou, Eleni Douni. 2022, "Proteomic Identification of the SLC25A46 Interactome in Transgenic Mice Expressing SLC25A46-FLAG", J Proteome Res, 2022 Jan 5 doi: 10.1021/acs.jproteome.1c00728. Online ahead of print. [PubMed].

2021

Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis ,Robert-Jan Palstra, Tokameh Mahmoudi. 2021, "A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency", mBio. , 2021 Dec 7; e0298021. doi: 10.1128/mBio.02980-21. Online ahead of print. [PubMed].

George Stamatakis, Martina Samiotaki, Ioannis Temponeras, George Panayotou, Efstratios Stratikos. 2021, "Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 Spike Glycoprotein", J Biol Chem., 2021 Oct 21; 297(5):101329. doi: 10.1016/j.jbc.2021.101329. Online ahead of print. [PubMed].

Vasiliki-Dimitra C Tsolaki, Sofia K Georgiou-Siafis, Athina I Tsamadou, Stefanos A Tsiftsoglou, Martina Samiotaki, George Panayotou, Asterios S Tsiftsoglou. 2021, "Hemin accumulation and identification of a heme-binding protein clan in K562 cells by proteomic and computational analysis", J Cell Physiol., 2021 Oct 7. doi: 10.1002/jcp.30595. Online ahead of print. [PubMed].

Ioanna Maria Gkotinakou, Christina Befani, Martina Samiotaki, George Panayotou, Panagiotis Liakos. 2021, "Novel HIF-2α interaction with Reptin52 impairs HIF-2 transcriptional activity and EPO secretion", Biochem Biophys Res Commun., 2021 Jun 11; 557:143-150. doi: 10.1016/j.bbrc.2021.03.176. Epub 2021 Apr 14. [PubMed].

Kreon Koukoulas, Antonis Giakountis, Angeliki Karagiota, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis. 2021, "ERK signaling controls productive HIF-1 binding to chromatin and cancer cell adaptation to hypoxia through HIF-1α interaction with NPM1", Mol Oncol., 2021 Aug 13. doi: 10.1002/1878-0261.13080. Online ahead of print. [PubMed].

2020

George Stamatakis, Martina Samiotaki, Anastasia Mpakali, George Panayotou, Efstratios Stratikos. 2020, "Generation of SARS-CoV-2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases", J Proteome Res. , 2020 Sep 22. doi: 10.1021/acs.jproteome.0c00457. Online ahead of print. [PubMed].

Georgiou-Siafis,S.K., Samiotaki,M.K., Demopoulos,V.J., Panayotou,G. , and Tsiftsoglou,A.S. 2020, "Forma- tion of novel N-acetylcysteine-hemin adducts abrogates hemin-induced cytotoxicity and suppresses the NRF2- driven stress response in human pro-erythroid K562 cells.", Eur. J. Pharmacol. , 173077 [PubMed].

Ninou I, Sevastou I, Magkrioti C, Kaffe E, Stamatakis G, Thivaios S, Panayotou G, Aoki J, Kollias G, Aidinis V. 2020, "Genetic deletion of Autotaxin from CD11b+ cells decreases the severity of experimental autoimmune encephalomyelitis.", PLoS One, 15(4) :e0226050 [PubMed].

2019

Daras G, Rigas S, Alatzas A, Samiotaki M, Chatzopoulos D, Tsitsekian D, Papadaki V, Templalexis D, Banilas G, Athanasiadou AM, Kostourou V, Panayotou G, Hatzopoulos P. 2019, "LEFKOTHEA Regulates Nuclear and Chloroplast mRNA Splicing in Plants", Developmental Cell. , 12. pii: S1534-5807(19)30630-6. 2019 [PubMed].

Katerina Papanikolopoulou, Jean Gouzi, Ilianna Roussou, Martina Samiotaki and Efthimios Skoulakis 2019, "Drosophila Tau negatively regulates translation and olfactory Long-Term Memory, but facilitates footshock habituation and cytoskeletal homeostasis", Journal of Neuroscience. , 39, 8315-8329 [PubMed].

Foteini Violitzi, Vasiliki-Iris Perivolidi, Trias Thireou, Ioannis Grivas, Sylva Haralambous, Martina Samiotaki, George Panayotou, Eleni Douni. 2019, "Mapping interactome networks of DNAJC11, a novel mitochondrial protein causing neuromuscular pathology in mice", J Proteome Res. , 18(11): 3896-3912. 2019 [PubMed].

Papadaki M, Rinotas V, Violitzi F, Thireou T, Panayotou G, Samiotaki M, Douni E. 2019, "New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis.", Front Immunol., 2019 Feb 5; 10:97. doi: 10.3389/fimmu.2019.00097. eCollection 2019. [PubMed].

2018

Papadopoulou LC, Ingendoh-Tsakmakidis A, Mpoutoureli CN, Tzikalou LD, Spyridou ED, Gavriilidis GI, Kaiafas GC, Ntaska AT, Vlachaki E, Panayotou G, Samiotaki M, Tsiftsoglou AS. 2018, "Production and Transduction of a Human Recombinant β-Globin Chain into Proerythroid K-562 Cells To Replace Missing Endogenous β-Globin.", Mol Pharm., 2018 Dec 3; 15(12):5665-5677. doi: 10.1021/acs.molpharmaceut.8b00857. Epub 2018 Nov 12. [PubMed].

2017

Chatzileontiadou DSM, Samiotaki M, Alexopoulou AN, Cotsiki M, Panayotou G, Stamatiadi M, Balatsos NAA, Leonidas DD, Kontou M. 2017, "Proteomic Analysis of Human Angiogenin Interactions Reveals Cytoplasmic PCNA as a Putative Binding Partner.", J Proteome Res. , 2017 Oct 6; 16(10):3606-3622. doi: 10.1021/acs.jproteome.7b00335. Epub 2017 Sep [PubMed].

Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E. 2017, "Novel insights into SLC25A46-related pathologies in a genetic mouse model.", PLoS Genet. , 2017 Apr 4; 13(4):e1006656. doi: 10.1371/journal.pgen.1006656. eCollection 2017 Apr. [PubMed].

Fouka P, Alexopoulos H, Chatzi I, Dedos SG, Samiotaki M, Panayotou G, Politis P, Tzioufas A, Dalakas MC. 2017, "Antibodies to inositol 1,4,5-triphosphate receptor 1 in patients with cerebellar disease", Neurol Neuroimmunol Neuroinflamm. , 2016 Dec 5; 4(1):e306. eCollection 2017 Jan. [PubMed].

Mylonis I, Kourti M, Samiotaki M, Panayotou G, Simos G. 2017, "Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia.", J Cell Sci. 2, 017 Jan 15; 130(2):466-479. doi: 10.1242/jcs.195339. Epub 2016 Dec 1. [PubMed].

2016

Pangou E, Befani C, Mylonis I, Samiotaki M, Panayotou G, Simos G, Liakos P. 2016, "HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.", J Cell Sci. , 2016 Nov 15; 129(22):4213-4226. Epub 2016 Sep 29. [PubMed].

Elkouris M, Kontaki H, Stavropoulos A, Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Saviolaki D, Brown PJ, Sideras P, Panayotou G, Talianidis I. 2016, "SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.", Cell Rep. , 2016 Jun 21; 15(12):2733-44. doi: 10.1016/j.celrep.2016.05.051. Epub 2016 Jun 9. [PubMed].

Agallou M, Athanasiou E, Samiotaki M, Panayotou G, Karagouni E. 2016, "Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis.", PLoS One. , 2016 Feb 23; 11(2):e0149894. doi: 10.1371/journal.pone.0149894. eCollection 2016. [PubMed].

Moulos P, Samiotaki M, Panayotou G, Dedos SG 2016, "Combinatory annotation of cell membrane receptors and signalling pathways of Bombyx mori prothoracic glands", Sci Data. , 2016 Aug 30; 3:160073. doi: 10.1038/sdata.2016.73. [PubMed].

2015

Vandera E, Samiotaki M, Parapouli M, Panayotou G , Koukkou AI. 2015, "Comparative proteomic analysis of Arthrobacter phenanthrenivorans Sphe3 on phenanthrene, phthalate and glucose.", J Proteomics., 2015 Jan 15; 113:73-89. doi: 10.1016/j.jprot.2014.08.018. Epub 2014 Oct 1. [PubMed].

2013

Oehrl, W., Cotsiki, M. and Panayotou G. 2013, "Differential regulation of M3/6 (DUSP8) signalling complexes in response to arsenite-induced oxidative stress.", Cell. Signal. , 25, 429–438 [PubMed].

Alexandratos A, Clos J, Samiotaki M, Efstathiou A, Panayotou G , Soteriadou K, Smirlis D. 2013, "The loss of virulence of histone H1 overexpressing Leishmania donovani parasites is directly associated with a reduction of HSP83 rate of translation.", Mol Microbiol., 2013 Jun; 88(5):1015-31. doi: 10.1111/mmi.12240. Epub 2013 May 7. [PubMed].

2012

Ikonomou G, Kostourou V, Shirasawa S, Sasazuki T, Samiotaki M, Panayotou G. 2012, "Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.", J Proteomics. , 2012 Jul 16. [Epub ahead of print] [PubMed].

Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G. ,Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM, Stratikos E. 2012, "A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing.", J Immunol. , 2012 Jul 25. [Epub ahead of print] [PubMed].

Karkali K, Panayotou G. 2012, "The Drosophila DUSP Puckered is phosphorylated by JNK and p38 in response to arsenite-induced oxidative stress.", Biochem Biophys Res Commun. , 2012 Feb 10; 418(2):301-6. Epub 2012 Jan 12. [PubMed].

2011

Cotsiki M, Oehrl W, Samiotaki M, Theodosiou A, Panayotou G. 2011, "Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.", Cell Signal. , 2012 Mar; 24(3):664-76. Epub 2011 Nov 9. [PubMed].

Gkiafi Z, Panayotou G. 2011, "Comparative Proteomic Analysis Implicates COMMD Proteins as Epstein-Barr Virus Targets in the BL41 Burkitt's Lymphoma Cell Line.", J Proteome Res. , 2011 Jun 14. [Epub ahead of print] [PubMed].

2010

Makridakis M, Roubelakis MG, Bitsika V, Dimuccio V , Samiotaki M, Kossida S,, Panayotou G, Coleman J, Candiano G, Anagnou NP, Vlahou A. 2010, "Analysis of secreted proteins for the study of bladder cancer cell aggressiveness. ", J Proteome Res. , 2010 Jun 4;9(6): , 3243-59. [PubMed].

Tsangaridou E, Polioudaki H, Sfakianaki R, Samiotaki M, Tzardi M, Koulentaki M, Panayotou G , Kouroumalis E, Castanas E, Theodoropoulos PA., 2010, "Differential detection of nuclear envelope autoantibodies in primary biliary cirrhosis using routine and alternative methods .", BMC Gastroenterol , 10. , 28 [PubMed].

Rapti A, Trangas T, Samiotaki M , Ioannidis P, Dimitriadis E, Meristoudis C, Veletza S, Courtis N. 2010, "The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation .", Mol Cell Biochem. , . , Epub ahead of print [PubMed].

Chandris P, Giannouli CC, Panayotou G , Kletsas D. 2010, "Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428) .", Biogerontology. , . , Epub ahead of print [PubMed].

Parapouli M, Fragkos-Livanios L, Samiotaki, M, Koukkou A, Perisynakis A, Hatziloukas E, Panayotou G , Drainas C. 2010, "Comparative proteomic analysis of alcoholic fermentation employing a new environmental strain of Saccharomyces cerevisiae .", Process Biochemistry. , . , Epub ahead of print [PubMed].

Sikara MP, Routsias JG, Samiotaki M, Panayotou G , Moutsopoulos HM, Vlachoyiannopoulos PG. 2010, "β2 glycoprotein I (β2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome .", Blood. , 115. , 713-723 [PubMed].

Gorbenko O, Panayotou G, , Zhyvoloup A, Volkova D, Gout I, Filonenko V. 2010, "Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4 .", Mol Cell Biochem . , 337. , 299-305 [PubMed].

2009

Ikonomou, G., Samiotaki, M. and Panayotou, G. 2009, " Proteomic methodologies and their application in colorectal cancer research .", Crit. Rev. Clin. Lab. Sci . , 46. , 319-342 [PubMed].

Psarra AM, Hermann S, Panayotou G, Spyrou G. 2009, "Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaBeta modulates glucocorticoid receptor and NF-kappaB signaling in HEK 293 cells .", Biochem J. . , 422. , 521-531 [PubMed].

Stamatakis G, Tsantila N, Samiotaki M, Panayotou GN, , Dimopoulos AC, Halvadakis CP, Demopoulos CA. 2010, "Detection and isolation of antiatherogenic and antioxidant substances present in olive mill wastes by a novel filtration system .", J Agric Food Chem. , 57. , 10554-10564 [PubMed].

2008

Oehrl W. and Panayotou, G. 2008, "Modulation of growth factor action by the extracellular matrix .", Connect Tissue Res . , 49. , 145-148 [PubMed].

Petroutsos D, Katapodis P, Samiotaki M, Panayotou G , Kekos D. 2008, "Detoxification of 2,4-dichlorophenol by the marine microalga Tetraselmis marina .", Phytochemistry , 69. , 707-714 [PubMed].

Thireos G, Panayotou G.,Thanos D. , 2008, "Biochemistry and molecular biology research achievements in Greece.", IUBMB Life, 2008 May;60(5), 254-7 [PubMed].

Lionaki E, de Marcos Lousa C, Baud C, Vougioukalaki M, Panayotou G., Tokatlidis K., 2008, "The Essential Function of Tim12 in Vivo Is Ensured by the Assembly Interactions of Its C-terminal Domain.", J Biol Chem., 2008 Jun 6, 283(23):15747-53 [PubMed].

Koliaraki V, Marinou M, Samiotaki M, Panayotou G., Pantopoulos K, Mamalaki A., 2008, "Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.", Biochimie., 2008 May, 90(5):726-35 [PubMed].

2007

Maratheftis CI, Giannouli S, Spachidou MP, Panayotou G., Voulgarelis M., 2007, "RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II.", Neoplasia., 2007 Dec, 9(12):1012-20 [PubMed].

Karanasios E, Simader H, Panayotou G., Suck D, Simos G., 2007, "Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly.", J Mol Biol., 2007 Dec 7, 374(4):1077-90 [PubMed].

Petroutsos D, Katapodis P, Samiotaki M, Panayotou G., Kekos D., 2007, "Detoxification of 2,4-dichlorophenol by the marine microalga Tetraselmis marina.", Phytochemistry, 2008 Feb, 69(3):707-14 [PubMed].

Tsimogiannis D, Samiotaki M, Panayotou G., Oreopoulou V., 2007, "Characterization of flavonoid subgroups and hydroxy substitution by HPLC-MS/MS.", Molecules, 2007 Mar 21, 12(3):593-606 [PubMed].

Skopeliti M, Kratzer U, Altenberend F, Panayotou G, Kalbacher H, Stevanovic S, Voelter W, Tsitsilonis OE. 2007, "Proteomic exploitation on prothymosin alpha-induced mononuclear cell activation.", Proteomics, 7, 1814-1824, PubMed

Fragopoulou E, Nomikos T, Karantonis HC, Apostolakis C, Pliakis E, Samiotaki M, Panayotou G, Antonopoulou S. 2007, "Biological activity of acetylated phenolic compounds.", J Agric Food Chem., 2007 Jan 10, 55(1):80-9 PubMed

Stea EA, Routsias JG, Samiotaki M, Panayotou G, Papalambros E, Moutsopoulos HM, Tzioufas AG. 2007, "Analysis of parotid glands of primary Sjogren's syndrome patients using proteomic technology reveals altered autoantigen composition and novel antigenic targets.", Clin Exp Immunol, 2007 Jan, ;147(1):81-9 PubMed

2006

Janssens R, Dekker S, Hendriks RW, Panayotou G, Van Remoortere A, Kong-A San J, Grosveld F, Drabek D, 2006, "Generation of heavy-chain-only antibodies in mice.", Proc Natl Acad Sci U S A., 2006 Oct 2, Epub ahead of print. PubMed

Lindtner S, Zolotukhin AS, Uranishi H, Bear J, Kulkarni V, Smulevitch S, Samiotaki M, , Panayotou G , Felber BK, Pavlakis GN., 2006, "RBM15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.", J Biol Chem., 2006 Sep 25, Epub ahead of print . PubMed

Mylonis I, Chachami G, Samiotaki M,, Panayotou G , Paraskeva E, Kalousi A, Georgatsou E, Bonanou S, Simos G., 2006, "Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor 1a.", J Biol Chem., 2006 Sep 5, Epub ahead of print . PubMed

Tsoupras AB, Antonopoulou S, Baltas G, Samiotaki M, Panayotou G , Kotsifaki H, Mantzavinos Z, Demopoulos CA., 2006, "Isolation and identification of hydroxyl-platelet-activating factor from natural sources.", Life Sci., 2006 Oct 4, 79(19):1796-803.Epub 2006 Jun 14. PubMed

Vynios DH, Tsagaraki I, Grigoreas GH, Samiotaki M, Panayotou G , Kyriakopoulou D, Georgiou P, Korbakis D, Panayotou A, Nanouri K, Assouti M, Andonopoulos AP., 2006, "Isolation and identification of hydroxyl-platelet-activating factor from natural sources.", Biochimie, 2006 Jul, 88(7):767-73. Epub 2006 Jan 30. PubMed

Trougakos IP, Saridaki A, Panayotou G , Gonos ES., 2006, "Identification of differentially expressed proteins in senescent human embryonic fibroblasts.", Mech Ageing Dev., 2006 Jan, 127(1):88-92. Epub 2005 Oct 5. PubMed

2005

Saridaki A., Panayotou G., 2005, "Identification of growth factor-regulated proteins using 2D electrophresis and mass spectrometry", Growth Factors, 2005 Sep; 23(3):223-32.

2004

Nemazanyy I., Panasyuk G., Zhyvoloup A., Panayotou G., Gout I. T., Filonenko V., 2004, "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism", FEBS Lett., 578, 357-362 [PubMed].

Panayotou G., 2004, "Molecular analysis of signal transduction pathways", Autoimmun. Rev., 3, S28-9 [PubMed].

Sidera K., Samiotaki M., Yfanti E., Panayotou G., Patsavoudi E., 2004, "Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system", J. Biol. Chem., 279, 45379-45388 [PubMed].

Foukas L. C., Panayotou G., Shepherd P. R., 2004, "Direct interaction of MHC class II derived peptides with class Ia PI 3-kinase results in dose-dependent stimulatory effects", J. Biol. Chem., 279, 7505-7511 [PubMed].

2003

Vardakou M., Katapodis P., Samiotaki M., Kekos D., Panayotou G., Christakopoulos P., 2003, "Mode of action of family 10 and 11 endoxylanases on water-unextractable arabinoxylan", Int. J. Biol. Macromol., 33, 129-34 [PubMed].

Dekker S., Toussaint W., Panayotou G., de Wit T., Visser P., Grosveld F., Drabek D., 2003, "Intracellularly expressed single domain antibody prevents the production of porcine retroviruses", J. Virol., 77, 12132-12139 [PubMed].

Staikou E. V., Routsias J. G., Makri A. A., Terzoglou A., Sakarellos-Daitsiotis M., Sakarellos C., Panayotou G., Moutsopoulos H. M., Tzioufas A. G., 2003, "Calreticulin binds preferentially with B cell linear epitopes of Ro60 kD autoantigen, enhancing recognition by anti-Ro60 kD autoantibodies", Clin. Exp. Immunol., 134, 143-50 [PubMed].

Zamanou A., Samiotaki M., Panayotou G., Margaritis L., Lymberi P., 2003, "Fine specificity and subclasses of IgG anti-actin autoantibodies differ in health and disease", J. Autoimm., 20, 333-334 [PubMed].

2002

Gonos E. S., Agrafiotis D., Dontas A. S., Efthimiopoulos S., Galaris D., Karamanos N. K., Kletsas D., Kolettas E., Panayotou G., Pratsinis H., Sekeri-Pataryas K. E., Simoes D., Sourlingas T. G., Stathakos D., Stratigos A. J., Tavernarakis N., Trougakos I. P., Tsiganos C. P., Vynios D. H., 2002, "Ageing research in Greece", Exp. Gerontol., 37 (6), 735-747 [PubMed].

Chan T. O., Rodeck U., Chan A. M., Kimmelman A. C., Rittenhouse S. E., Panayotou G., Tsichlis P. N., 2002, "Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit", Cancer Cell, 1, 181-191 [PubMed].

Theodosiou A. ,and Ashworth A., 2002, "MAP kinase phosphatases", Genome Biol., 3(7) , 3009 (1-10) [PubMed].

2001

Panayotou G., Ladbury J., 2001, "Analysis of SH2 domain - phosphopeptide interactions by Isothermal Titration Calorimetry and Surface Plasmon Resonance", Methods Mol. Biol., 124, 295-311 [PubMed].

2000

Rosler A., Panayotou G., Hornby D. P., Barlow T., Brown T., Pearl L. H., Savva R., Blackburn G. M., 2000, "The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues", Nucleosides Nucleotides Nucleic Acids, 19, 1505-1516 [PubMed].

Baynes K. C., Beeton C. A., Panayotou G., Stein R., Soos M., Hansen T., Simpson H., O'Rahilly S., Shepherd P. R., Whitehead J. P., 2000, "Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity", Diabetologia, 43, 321-331 [PubMed].

1999

Greagg M. A., Fogg M. J., Panayotou G., Evans S. J., Connolly B. A., Pearl L. H., 1999, "A read-ahead function in archaeal DNA polymerases detects pro-mutagenic template-strand uracil", Proc. Natl. Acad. Sci. U.S.A., 96, 9045-9050 [PubMed].

Chaudri Z. N., Barlet-Jones M., Panayotou G., Klonisch T., Roitt I. M., Lund T., Delves P. J., 1999, "Dual specificity antibodies using a double-stranded oligonucleotide bridge", FEBS Lett., 450, 23-26 [PubMed].

Lo Surdo P., Bottomley M. J., Arcaro A., Siegal G., Panayotou G., Sankar A., Gaffney P. R. J., Riley A. M., Potter B. V. L., Waterfield M. D., Driscoll P. C., 1999, "Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85α SH2 domains with phosphoinositides and inositol polyphosphates", J. Biol. Chem., 274, 15678-15685 [PubMed].

Harpur A. G., Layton M. J., Das P., Bottomley M. J., Panayotou G., Driscoll P. C., Waterfield M. D., 1999, "Intermolecular interactions of the p85 a regulatory subunit of phosphatidylinositol 3-kinase", J. Biol. Chem., 274, 12323-12332 [PubMed].

1998

Keusch J., Panayotou G., Malissard M., Berger E. G., Appert H. E., Lydyard P. M., Delves P. J., 1998, "Antibody recognition of epitopes on wild-type and mutant β-(1>4)-galactosyltransferase-1", Carbohydrate Res., 313, 37-48 [PubMed].

Bottomley M. J., Salim K., Panayotou G., 1998, "Phospholipid-binding protein domains", Biochim. Biophys. Acta, 1436, 165-183 [PubMed].

Layton M. J., Harpur A. G., Panayotou G., Bastiens P. I. H., Waterfield M. D., 1998, "Binding of a diphosphotyrosine-containing peptide that mimics activated Platelet-derived Growth Factor Receptor β induces oligomerisation of phosphatidylinositol 3-kinase", J. Biol. Chem., 273, 33379-33385 [PubMed].

Panayotou G., 1998, "Surface Plasmon Resonance: Measuring protein interactions in real time", Methods Mol. Biol., 88, 1-10 [PubMed].

Siegal G., Davis B., Kristensen S. M., Sankar A., Linacre J., Stein R., Panayotou G., Waterfield M. D., Driscoll P. C., 1998, "Solution structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase", J. Mol. Biol., 276, 461-478 [PubMed].

Barrett T. E., Savva R., Panayotou G., Barlow T., Brown T. A., Jiricny J., Pearl L. H., 1998, "Crystal structure of a G:T/U mismatch-specific DNA glycosylase: Mismatch recognition by complementary-strand interactions", Cell, 92, 117-129 [PubMed].

Flynn P., Mellor H., Palmer R., Panayotou G., Parker P. J., 1998, "Multiple interactions of PRK1 with RhoA. Functional assignment of the HR1 repeat motif", J. Biol. Chem., 273, 2698-2705 [PubMed].

Panayotou G., Brown T., Barlow T., Pearl L. T., Savva R., 1998, "Direct measurement of the substrate preference of Uracil-DNA Glycosylase", J. Biol. Chem., 273, 45-50 [PubMed].

Panayotou G., 1998, "Surface Plasmon Resonance", In 'Encyclopedia of Immunology' (2nd edition; eds. Delves and Roitt), Academic Press, 2247-2250.

1997

Vanhaesebroeck B., Leevers S. J., Panayotou G., Waterfield M. D., 1997, "Phosphoinositide 3-kinases: a conserved family of signal transducers", Trends Biochem. Sci., 22, 267-272 [PubMed].

Reith A. D., Panayotou G., 1997, "Growth factor signalling pathways in cancer", In 'Cellular and Molecular Biology of Cancer', (eds. Franks and Teich), 3rd edition, Oxford University Press, 230-250.

1996

Salim K., Bottomley M. J., Querfurth E., Zvelebil M., Gout I., Scaife R., Margolis R. L., Gigg R., Smith C. I. E., Driscoll P. C., Waterfield M. D., Panayotou G., 1996, "Distinct specificity in the recognition of phosphoinositides by the Pleckstrin Homology domains of dynamin and Bruton's tyrosine kinase (Btk)", EMBO J., 15, 6241-6250 [PubMed].

Klonisch T., Panayotou G., Edwards P., Jackson A. M., Berger P., Delves P. J., Lund T., Roitt I. M., 1996, "Enhancement in antigen binding by a combination of synergy and antibody capture", Immunology, 89, 165-171 [PubMed].

Spanopoulou E., Zaitseva F., Wang F-H., Santagata S., Baltimore D., Panayotou G., 1996, "The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination", Cell, 87, 263-276 [PubMed].

Ladbury J..E., Hensmann M., Panayotou G., Campbell I. D., 1996, "Alternative modes of tyrosyl phosphopeptide binding to a Src family SH2 domain: Implications for regulation of tyrosine kinase activity", Biochemistry, 35, 11062-11069 [PubMed].

Klonisch T., Delves P., Berger P., Panayotou G., Lapthorn A. J., Isaacs N. W., Wick G., Lund T., Roitt I. M., 1996, "Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model", Eur. J. Immunol., 26, 1897-1905 [PubMed].

Wientjes F. B., Panayotou G., Reeves E., Segal A. W., 1996, "Interactions between cytosolic components of the NADPH oxidase-p40phox interacts with both p67phox and p47phox", Biochem. J., 317, 919-924 [PubMed].

Wymann M. P., Bulgarelli-Leva G., Zvelebil M. J., Pirola L., Vanhaesebroeck B., Waterfield M. D., Panayotou G., 1996, "Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction", Mol. Cell. Biol., 16, 1722-1733 [PubMed].

Zvelebil M. J., MacDougall L., Leevers S., Volinia S., Vanhaesebroeck B., Gout I., Panayotou G., Domin J., Stein R., Pages F., Koga H., Salim K., Linacre J., Das P., Panaretou C., Wetzker R., Waterfield M. D., 1996, "Structural and functional diversity of phosphoinositide 3-kinases", Phil. Trans. R. Soc. Lond., 351, 217-223 [PubMed].

Ellis C., Kasmi F., Ganju P., Walls E., Panayotou G., Reith A. D., 1996, "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn", Oncogene, 12, 1727-1736 [PubMed].

Panayotou G., 1996, "Multiple roles for PI 3-kinases in signal transduction", In 'Signal Transduction' (eds. Heldin C.-H. and Purton M.), Chapman and Hall, 189-204.

1995

Zvelebil M., Panayotou G., Waterfield M. D., 1995, "Prediction and analysis of SH2 domain - phosphopeptide interactions", Protein Engineering, 8, 527-533 [PubMed].

Pelicci G., Giordano S., Zhen Z., Salcini A. E., Lanfrancone L., Bardelli A., Panayotou G., Waterfield M. D., Ponzetto C., Pelicci P. G., Comoglio P. M., 1995, "The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein", Oncogene, 10, 1631-1638 [PubMed].

1994

Dhand R., Hiles I., Panayotou G., Fry M. J., Roche S., Gout I., Totty N. F., Truong O., Yonezawa K., Kasuga M., Courtneidge S., Waterfield M. D., 1994, "PI 3-kinase is a dual specificity kinase: Autoregulation by an intrinsic protein-serine kinase activity", EMBO J., 13, 522-533 [PubMed].

Dhand R., Hara K., Hiles I., Bax B., Gout I., Panayotou G., Fry M. J., Yonezawa K., Kasuga M., Waterfield M. D., 1994, "PI 3-kinase: Structural and functional analysis of intersubunit interactions", EMBO J., 13, 511-521 [PubMed].

Hensmann M., Booker G. W., Panayotou G., Boyd J., Linacre J., Waterfield M. D., Campbell I. D., 1994, "Phosphopeptide binding to the N-terminal SH2 domain of the p85α subunit of PI 3-kinase: A heteronuclear NMR study", Protein Science, 3, 1020-1030 [PubMed].

Ponzetto C., Bardelli A., Zhen Z., della Zonca P., Maina F., Giordano S., Graziani A., Panayotou G., Comoglio P. M., 1994, "A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor / scatter factor (HGF/SF) receptor family", Cell, 77, 261-271 [PubMed].

1993

Panayotou G., Waterfield M. D., End P., 1993, "Riding the evanescent wave", Current Biol., 3, 913-915 [PubMed].

Gout I., Dhand R., Hiles I. D., Fry M. J., Panayotou G., Das P., Truong O., Totty N. F., Hsuan J., Booker G. W., Campbell I. D., Waterfield M. D., 1993, "The GTPase dynamin binds to and is activated by a subset of SH3 domains", Cell, 75, 25-36 [PubMed].

Panayotou G., Gish G., End P., Truong O., Gout I., Dhand R., Fry M. J., Hiles I., Pawson T., Waterfield M. D., 1993, "Interactions between SH2 domains and tyrosine-phosphorylated PDGF β-receptor sequences: Analysis of kinetic parameters using a novel biosensor-based approach", Mol. Cell. Biol., 13, 3567-3576 [PubMed].

Panayotou G., Waterfield M. D., 1993, "The assembly of signalling complexes by activated growth factor receptors", BioEssays, 15, 171-177 [PubMed].

Ruiz-Larrea F., Vicendo P., Yaish P., End P., Panayotou G., Fry M. J., Morgan S. J., Thompson A., Parker P. J., Waterfield M. D., 1993, "Characterisation of the bovine brain cytosolic phosphatidylinositol 3-kinase complex", Biochem. J., 290, 609-616 [PubMed].

Fry M. J., Panayotou G., Booker G. W., Waterfield M. D., 1993, "New insights into protein-tyrosine kinase receptor signalling complexes", Protein Science, 2, 1785-1797 [PubMed].

Ponzetto C., Bardelli A., Maina F., Longati P., Panayotou G., Dhand R., Waterfield M. D., Comoglio P. M., 1993, "A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the Hepatocyte Growth Factor / Scatter Factor receptor", Mol. Cell. Biol., 13, 4600-4608 [PubMed].

End P., Gout I., Fry M. J., Panayotou G., Dhand R., Yonezawa K., Kasuga M., Waterfield M. D., 1993, "A biosensor approach to probe the structure and function of the p85α subunit of the PI 3-kinase complex", J. Biol. Chem., 268, 10066-10075 [PubMed].

White H., Totty N., Panayotou G., 1993, "Haemonectin, a granulocytic cell binding protein, is highly related to the plasma glycoprotein fetuin", Eur. J. Biochem., 213, 523-528 [PubMed].

1992

Panayotou G., Waterfield M. D., 1992, "Phosphatidylinositol 3-kinase: a key enzyme in diverse signalling processes", Trends Cell Biol., 2, 358-360 [PubMed].

Panayotou G., Fry M. J., Waterfield M. D., 1992, "Multi-enzyme complexes associated with receptors during signal transduction", C. R. Acad. Sci. Paris, 314, 11-20 [PubMed].

End P., Panayotou G., Entwistle A., Waterfield M. D., Chiquet M., 1992, "Tenascin: a modulator of cell growth", Eur. J. Biochem., 209, 1041-1051 [PubMed].

McGlade C. J., Ellis C., Reedijk M., Anderson D., Mbamalu G., Reith A. D., Panayotou G., End P. Bernstein A., Kazlauskas A., Waterfield M. D., Pawson T., 1992, "SH2 domains of the p85α subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors", Mol. Cell. Biol., 12, 991-997 [PubMed].

Goot I., Dhand R., Panayotou G., Fry M. J., Waterfield M. D., 1992, "Expression and characterisation of two 85 kDa components of the PI 3-kinase complex using baculovirus vectors", Biochem. J., 288, 395-405 [PubMed].

Panayotou G., Bax B., Gout I., Federwisch M., Wroblowski B., Dhand R., Fry M. J., Blundell T. L., Wollmer A., Waterfield M. D., 1992, "Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: Structural features and analysis of conformational changes", EMBO J., 11, 4261-4272 [PubMed].

Booker G. W., Breeze A. L., Downing A. K., Panayotou G., Gout I., Waterfield M. D., Campbell I. D., 1992, "Structure of an SH2 domain of the p85α subunit of phosphatidylinositol 3-kinase", Nature, 358, 684-687 [PubMed].

Hiles I. D., Otsu M., Volinia S., Fry M. J., Gout I., Dhand R., Panayotou G., Ruiz-Larrea F., Thompson A., Totty N. F., Hsuan J. J., Courtneidge S. A., Parker P. J., Waterfield M. D., 1992, "Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit", Cell, 70, 419-429 [PubMed].

Fry M. J., Panayotou G., Ruiz-Larrea F., Waterfield M. D., 1992, "Purification and charaterisation of the binding specificity of the PtdIns 3-kinase complex of bovine brain using phosphopeptide affinity columns", Biochem. J., 288, 383-393 [PubMed].

1991

Otsu M., Hiles I., Gout I., Fry M. J., Ruiz-Larrea F., Panayotou G., Thompson A., Dhand R., Hsuan J., Totty N., Smith A. D., Morgan S., Courtneidge S. A., Parker P., Waterfield M. D., 1991, "Characterization of two 85 kDa proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase", Cell, 65, 91-104 [PubMed].

Khazaie K., Panayotou G., Aguzzi A., Samarut J., Gazzolo L., Jurdic P., 1991, "EGF promotes in vivo tumorigenic growth of primary chicken embryo fibroblasts expressing v-myc and enhances in vitro transformation by the v-erbA oncogene", Oncogene, 6, 21-28 [PubMed].

Fry M. J., Panayotou G., Waterfield M. D., 1991, "Oncogenes and their relation to growth regulating receptors", In 'Receptor Sub-units and Complexes' (eds. Bergen A. S. V., Roberts G. C. K.), Cambridge University Press, 15.

1990

Panayotou G., Haley J. D., Hsuan J. J., Clark S., Waterfield M. D., 1990, "The structure and function of growth factor receptors and their subversion in cancer", In 'New Concepts in Cancer: Metastasis, Oncogenes and Growth Factors' (eds. C. Etievant, J. Cros and Y. M.Rustum - Macmillan Press, London), 166-180.

Panayotou G., Gregoriou M., 1990, "Purification of the epidermal growth factor receptor from A431 cells", In 'Receptor Biochemistry, A Practical Approach' (ed. E. Hulme), IRL Press, Oxford/Washington DC, 203-211.

1989

Panayotou G., Waterfield M. D., 1989, "Cell surface receptors for polypeptide hormones, growth factors and neuropeptides", Current Opin. Cell Biol., 1, 167-176 [PubMed].

Panayotou G., End P., Aumaily M., Timpl R., Engel J., 1989, "Domains of laminin with growth factor activity", Cell, 56, 93-101 [PubMed].

Hsuan J. J., Panayotou G., Waterfield M. D., 1989, "Structural basis for epidermal growth factor receptor function", In 'Progress in Growth Factor Research' (ed. J. K. Heath), 1, 23-32 [PubMed].

Panayotou G., Hsuan J. J., Waterfield M. D., 1989, "Ligand- and antibody-affinity purification of the EGF receptor", In 'Receptor Purification' (ed. G. Litwack - Humana Press, New Jersey), 1, 289-302.

1988

Farzaneh F., Panayotou G. N., Bowler L. D., Hardas B. D., Broom T., Walther C., Shall,S., 1988, "ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome", Nucleic. Acids. Res., 16, 11319-11326 [PubMed].

Pallen C. J., Sahlin L., Panayotou G., Waterfield M. D., 1988, "Purification and characterization of placental membrane phosphotyrosine phosphatases", Cold Spring Harbor Symp. Quant. Biol., 53, 447-454 [PubMed].

Pallen C. J., Panayotou G. N., Sahlin L., Waterfield M. D., 1988, "Purification of a phosphotyrosine phosphatase that dephosphorylates the epidermal growth factor receptor autophosphorylation sites", Ann. N.Y. Acad. Sci., 551, 299-308 [PubMed].

1986

Panayotou G., Magee A., Gregoriou M., Rees A., Geisow M. J., 1986, "Transfer of reconstituted EGF receptor to receptor-negative cells by liposome fusion", Trans. Biochem. Soc., 14, 298-299.

1985

Panayotou G. N., Magee A. I., Geisow M. J., 1985, "Reconstitution of the epidermal growth factor receptor in artificial lipid bilayers", FEBS Lett., 183, 321-325.

1984

Geisow M. J., Childs J., Dash B., Harris A., Panayotou G., Sudhof T., Walker J. H., 1984, "Cellular distribution of three mammalian calcium-binding proteins related to Torpedo calelectrin", EMBO J., 3, 2969-2974 [PubMed].

Shall S., Creissen D., Farzaneh F., Irwin J., Murray B., Panayotou G., Tavassoli M., Tavassoli M., 1984, "ADP-Ribose in DNA repair and carcinogenesis", In 'Genes and Cancer' (eds. Bishop J. M., Rowley J. D., Greaves M. - Liss, New York), 175-183.

George Panayotou Research Group