Maria Tsoumakidou Research Group

Tsoumakidou M. The advent of immune stimulating CAFs in cancer. Nat Rev Cancer (in press)

Aerakis E, Chatzigeorgiou A, Kerdidani D, Angelidis I, Matthaiakaki M, Malissen B, Henri S, Tsoumakidou M. Interferon-induced lysosomal membrane permeabilization causes cDC1-deserts in tumors. bioRxiv; doi:

Kerdidani D, Aerakis E, Verrou K.M, Angelidis I, Douka K, Maniou M.A, Stamoulis P, Goudevenou K, Prados A, Tzaferis C, Ntafis V, Vamvakaris I, Kaniaris E, Vachlas K, Sepsas E, Koutsopoulos A, Potaris K, Tsoumakidou M. Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. J Exp Med. 2022; 219 (2): e20210815. doi: 10.1084/jem.20210815

Kerdidani D, Chouvardas P, Arjo AR, Giopanou I, Ntaliarda G, Guo YA, Tsikitis M, Kazamias G, Potaris K, Stathopoulos GT, Zakynthinos S, Kalomenidis I, Soumelis V, Kollias G, Tsoumakidou M. Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma. Nat Commun. 2019;10(1):1405.

Kerdidani D, Magkouta S, Chouvardas P, Karavana V, Glynos K, Roumelioti F, Zakynthinos S, Wauters E, Janssens W, Lambrechts D, Kollias G, Tsoumakidou M. Cigarette Smoke-Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells. J Immunol. 2018;201(5):1558-1569.

Tsoumakidou M*, Tousa S, Semitekolou M, Panagiotou P, Panagiotou A, Morianos I, Litsiou E, Trochoutsou AI, Konstantinou M, Potaris K, Footitt J, Mallia P, Zakynthinos S, Johnston SL, Xanthou G*. Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand. J Allergy Clin Immunol. 2014 Oct;134(4):944-954. *Co-correspondence.

Litsiou E, Semitekolou M, Galani I, Morianos I, Tsoutsa A, Kara P, Rontogianni D, Bellenis I, Konstantinou M, Potaris K, Andreakos E, Sideras P, Zakynthinos S, Tsoumakidou M. Reply: CXCL13 in tertiary lymphoid tissues: sites of production are different from sites of functional localization. Am J Respir Crit Care Med. 2014 Feb 1;189(3):370-1. 

Litsiou E, Semitekolou M, Galani IE, Morianos I, Tsoutsa A, Kara P, Rontogianni D, Bellenis I, Konstantinou M, Potaris K, Andreakos E, Sideras P, Zakynthinos S, Tsoumakidou M. CXCL13 production in B cells via Toll-like receptor/lymphotoxin receptor signaling is involved in lymphoid neogenesis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1194-202. 

Tsoumakidou M. The crucial task of defining a healthy immune response toward respiratory infections. J Allergy Clin Immunol. 2013 Apr;131(4):1260. 

Bouloukaki I, Tsiligianni IG, Tsoumakidou M, Mitrouska I, Prokopakis EP, Mavroudi I, Siafakas NM, Tzanakis N. Sputum and nasal lavage lung-specific biomarkers before and after smoking cessation. BMC Pulm Med. 2011 Jun 2;11:35.

Tsoumakidou M, Tsiligianni I, Tzanakis N. Mechanisms of altered cell immunity and cytotoxicity in COPD. Curr Drug Targets. 2011 Apr;12(4):450-9. 

Tsoumakidou M, Bouloukaki I, Thimaki K, Tzanakis N, Siafakas NM. Innate immunity proteins in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Exp Lung Res. 2010 Aug;36(6):373-80. 

Bouloukaki I, Tsoumakidou M, Vardavas CI, Mitrouska I, Koutala E, Siafakas NM, Schiza SE, Tzanakis N.Maintained smoking cessation for 6 months equilibrates the percentage of sputum CD8+ lymphocyte cells with that of nonsmokers. Mediators Inflamm. 2009;2009:812102. 

Tsoumakidou M, Bouloukaki I, Koutala H, Kouvidi K, Mitrouska I, Zakynthinos S, Tzanakis N, Jeffery PK, Siafakas NM. Decreased sputum mature dendritic cells in healthy smokers and patients with chronic obstructive pulmonary disease. Int Arch Allergy Immunol. 2009;150(4):389-97. 

Tsoumakidou M, Karagiannis KP, Bouloukaki I, Zakynthinos S, Tzanakis N, Siafakas NM. Increased bronchoalveolar lavage fluid CD1c expressing dendritic cells in idiopathic pulmonary fibrosis. Respiration. 2009;78(4):446-52.

Tsoumakidou M, Koutsopoulos AV, Tzanakis N, Dambaki K, Tzortzaki E, Zakynthinos S, Jeffery PK, Siafakas NM. Decreased small airway and alveolar CD83+ dendritic cells in COPD. Chest. 2009 Sep;136(3):726-33. 

Tsoumakidou M, Kemp SJ, Thorley AJ, Zhu J, Dewar A, Jeffery PK, Tetley TD. Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cells. Respir Med. 2009 Jun;103(6):935-8. 

Tsoumakidou M, Demedts IK, Brusselle GG, Jeffery PK. Dendritic cells in chronic obstructive pulmonary disease: new players in an old game. Am J Respir Crit Care Med. 2008 Jun 1;177(11):1180-6. 

Tsoumakidou M, Jeffery PK. Dendritic cell maturity and obstructive airway disease. Am J Respir Crit Care Med. 2007 Oct 15;176(8):833; author reply 833-4. 

Tsoumakidou M, Zhu J, Wang Z, Thorley A, Kemp S, Tetley T, Jeffery PK. Immunohistochemical detection of dendritic cells in human lung tissue. Histopathology. 2007 Oct;51(4):565-8. 

Mitrouska I, Tsoumakidou M, Prinianakis G, Milic-Emili J, Siafakas NM. Effect of voluntary respiratory efforts on breath-holding time. Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):290-4. 

Tsoumakidou M, Elston W, Zhu J, Wang Z, Gamble E, Siafakas NM, Barnes NC, Jeffery PK. Cigarette smoking alters bronchial mucosal immunity in asthma. Am J Respir Crit Care Med. 2007 May 1;175(9):919-25. 

Tsoumakidou M, Siafakas NM. Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations. Respir Res. 2006 May 22;7:80. 

Zervou MI, Tzortzaki EG, Makris D, Gaga M, Zervas E, Economidou E, Tsoumakidou M, Tzanakis N, Milic-Emili J, Siafakas NM. Differences in microsatellite DNA level between asthma and chronic obstructive pulmonary disease. Eur Respir J. 2006 Sep;28(3):472-8. 

Tsoumakidou M, Papadopouli E, Tzanakis N, Siafakas NM. Airway inflammation and cellular stress in noneosinophilic atopic asthma. Chest. 2006 May;129(5):1194-202.

Tsoumakidou M, Tzanakis N, Papadaki HA, Koutala H, Siafakas NM. Isolation of myeloid and plasmacytoid dendritic cells from human bronchoalveolar lavage fluid. Immunol Cell Biol. 2006 Jun;84(3):267-73.

Tsoumakidou M, Chrysofakis G, Tsiligianni I, Maltezakis G, Siafakas NM, Tzanakis N. A prospective analysis of 184 hemoptysis cases: diagnostic impact of chest X-ray, computed tomography, bronchoscopy. Respiration. 2006;73(6):808-14. 

Papadopouli E, Tzanakis N, Tsoumakidou M, Kyriakoy D, Plataki M, Mantzouranis EC, Siafakas NM. Comparison of induced sputum inflammatory profiles between childhood and adult-onset asthma. Respir Med. 2006 Aug;100(8):1442-50. 

Laboratory markers for COPD in "susceptible" smokers. Tzortzaki EG, Tsoumakidou M, Makris D, Siafakas NM. Clin Chim Acta. 2006 Feb;364(1-2):124-38. 

Nitrosative stress, heme oxygenase-1 expression and airway inflammation during severe exacerbations of COPD. Tsoumakidou M, Tzanakis N, Chrysofakis G, Siafakas NM. Chest. 2005 Jun;127(6):1911-8.

Tsoumakidou M, Tzanakis N, Chrysofakis G, Kyriakou D, Siafakas NM. Changes in sputum T-lymphocyte subpopulations at the onset of severe exacerbations of chronic obstructive pulmonary disease. Respir Med. 2005 May;99(5):572-9. 

Tsoumakidou M, Tzanakis N, Kyriakou D, Chrysofakis G, Siafakas NM. Inflammatory cell profiles and T-lymphocyte subsets in chronic obstructive pulmonary disease and severe persistent asthma. Clin Exp Allergy. 2004 Feb;34(2):234-40.

Tsoumakidou M, Tzanakis N, Voulgaraki O, Mitrouska I, Chrysofakis G, Samiou M, Siafakas NM. Is there any correlation between the ATS, BTS, ERS and GOLD COPD's severity scales and the frequency of hospital admissions? Respir Med. 2004 Feb;98(2):178-83.

Tzanakis N, Chrysofakis G, Tsoumakidou M, Kyriakou D, Tsiligianni J, Bouros D, Siafakas NM. Induced sputum CD8+ T-lymphocyte subpopulations in chronic obstructive pulmonary disease. Respir Med. 2004 Jan;98(1):57-65.

Chrysofakis G, Tzanakis N, Kyriakoy D, Tsoumakidou M, Tsiligianni I, Klimathianaki M, Siafakas NM. Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest. 2004 Jan;125(1):71-6.

Tsoumakidou M, Tzanakis N, Siafakas NM. Induced sputum in the investigation of airway inflammation of COPD. Respir Med. 2003 Aug;97(8):863-71. 

Siafakas NM, Stathopoulou M, Tzanakis N, Mitrouska I, Tsoumakidou M, Georgopoulos D. Effect of digoxin on global respiratory muscle strength after cholecystectomy: a double blind study. Thorax. 2000 Jun;55(6):497-501.