Highlights

09/05/2018

Expanding previous work on the role of autotaxin in chronic inflammatory disorders that has provided the scientific basis for phase IIb clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a role for this secreted lysophospholipase D in the pathogenesis of lung cancer [PubMed].

Read more: 09/05/2018

16/04/2018

Fleming researchers, using a Spondyloarthritis (SpA) mouse model have found that Tnfr2 signaling is regulating polyarthritis and a newly identified heart valve stenosis, which is a common comorbidity of SpA in human patients. [PubMed], [JCI Highlight].

Read more: 16/04/2018

30/03/2018

Rheumatoid arthritis and Spondyloarthritis are accompanied by several comorbid pathologies in human patients, often involving heart, lung and intestinal pathologies. Using the TNF-driven model of murine arthritis, Fleming researchers recently revealed the co-occurrence of arthritis with valvular heart disease. [PubMed], [Editorial].

Read more: 30/03/2018

06/03/2018

Two Fleming doctoral students (Panagiotis Chouvardas and Rania Semelidou) have been selected to attend the prestigious 68th Lindau Nobel Laureate Meeting, following a nomination by the Onassis Foundation. This year’s Meeting is dedicated to Physiology and Medicine and will bring together 600 young scientists and a record 43 Nobel Laureates.

Read more: 06/03/2018

15/02/2018

In a collaborative study published in Cell Reports, a Fleming Stavros Niarchos fellow uncovered a novel mechanism that determines the number of cortical interneurons in the brain. The research has important implications for improving the effectiveness of cell-based therapies for epilepsy syndromes. PubMed.

Read more: 15/02/2018

14/02/2018

Fleming researchers uncovered a molecular interplay between survival and death pathways in synovial fibroblasts mediating modelled Rheumatoid Arthritis. Their results suggest that combinatorial targeting of the IKK2/RIPK3 axis in chronic polyarthritis will be advantageous over targeting either of these pathways alone. Nat Commun , PubMed, Research highlight in Nature Reviews Rheumatology.

29/01/2018

In a collaborative study published in Nat Med, a Fleming Marie Curie Fellow revealed that aerosolized delivery of active Thyroid Hormone (TH) resolved pulmonary fibrosis in two mouse models through a mechanism that involved improvement of mitochondrial biogenesis and mitophagy in alveolar type II epithelial cells. PubMed.

Read more: 29/01/2018

23/01/2018

A summary of the pioneering work in the Skoulakis and Turin labs demonstrating the contribution of odorant vibrations to odor character and identification as recently published appeared in Vima Science 21/01/2018. Pubmed.

12/12/2017

Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins-exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis. Nat Com.

21/11/2017

On behalf of the Scientists and Personnel of BSRC Fleming I would like to express our sadness for the loss of Fotis Kafatos, an innovative mind that has influenced and shaped the development of Molecular Biology in Europe and in Greece. We extend our condolences to his family and the many students and colleagues he inspired through the years. 
George Kollias, President and Director of BSRC Fleming.

 

27/10/2017

Recently published work from the Skoulakis lab suggests that cortical actin rearrangements underlie the little understood Anesthesia Resistant Memory, whose molecular mechanisms remained mysterious to date. Pubmed

Read more: 27/10/2017

27/07/2017

The Genomics Facility of the BSRC Alexander Fleming, in collaboration with the lab of Iannis Talianidis, has developed a new high-throughput method for sequencing nascent RNAs labeled in vivo.

Read more: 27/07/2017

20/07/2017

BSRC Fleming has signed a MoU with the National Bank of Greece sharing the common vision of fostering innovation and entrepreneurship in emerging areas of modern research. This partnership aims to contribute to the translation of scientific achievements into clinical practice and the development of innovative products of high added value. Press Release (in Greek).

Read more: 20/07/2017

12/05/2017

Work by Fleming researchers has revealed that omic profiles of synovial fibroblasts from the Tg197 human TNF-transgenic model of arthritis greatly mimic human synovial fibroblast profiles from Rheumatoid arthritis patients, revealing commonly represented pathways that may constitute potential targets for future therapies (Pubmed, Editorial)

Read more: 12/05/2017

12/05/2017

Fleming researchers have identified two new dual inhibitors of TNF and RANKL, two key factors involved in inflammatory processes. These inhibitors can be further optimized to develop improved treatments for a range of inflammatory, autoimmune, and bone loss diseases (PubMed, Ηighlights in international press).

Read more: 12/05/2017

20/04/2017

Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot-Marie-Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia. Pubmed

Read more: 20/04/2017

19/12/2016

Expanding previous work on the role of autotaxin in chronic inflammatory disorders that have led to phase II clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a novel, major role for this secreted lysophospholipase D in the pathogenesis of hepatitis and hepatocellular carcinoma. PubMed.

Read more: 19/12/2016

20/09/2016

Fleming Researcher Dr Antigone Dimas has been awarded an ERC Starting Grant to explore the complex biological impact of dietary intake in humans. This is the fourth ERC grant awarded to a Fleming Researcher in the past 5 years. The title of Dr Dimas's grant is "A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans”. 

Read more: 20/09/2016

16/06/2016

Recent work by Fleming researchers identifies a Wnt-regulated long non-coding RNA that controls intestinal stem cell fate and carcinogenesis. Pubmed

Read more: 16/06/2016

16/06/2016

Recent work by Fleming researchers uncovered a protein methylation-dependent control mechanism in the pathogenesis of pulmonary fibrosis. Pubmed

Read more: 16/06/2016

28/04/2016

Τhe 2011 Nobel Laureate in Physiology or Medicine, Prof. Bruce Beutler, will be visiting Fleming, on Tuesday May 24th, 2016, and at 12 noon, he will be discussing his life in science in an "Ask the Nobelist" Q&A session targeted to young scientists (open to the public). Prof. Beutler will also be giving inaugural addresses at the Academy of Athens on May 23rd, 2016 at 20:00 and the University of Athens on May 24th, 2016 at 19:00.

Read more: 28/04/2016

01/03/2016

Recent work by Fleming researchers demonstrates that the histone methyltransferase Smyd3 is required for the development of experimentally induced liver and colon cancer in mice. Pubmed

Read more: 01/03/2016

18/02/2016

The study by Fleming researchers highlighted in December 2015 (Koliaraki et al., J. Exp. Med. 2015) is featured in a “News & Views” article in Nature. The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.

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