Highlights

12/5/2017

Work by Fleming researchers has revealed that omic profiles of synovial fibroblasts from the Tg197 human TNF-transgenic model of arthritis greatly mimic human synovial fibroblast profiles from Rheumatoid arthritis patients, revealing commonly represented pathways that may constitute potential targets for future therapies (Pubmed, Editorial)

Read more: 12/5/2017

12/05/2017

Fleming researchers have identified two new dual inhibitors of TNF and RANKL, two key factors involved in inflammatory processes. These inhibitors can be further optimized to develop improved treatments for a range of inflammatory, autoimmune, and bone loss diseases (PubMed, Ηighlights in international press).

Read more: 12/05/2017

20/04/2017

Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot-Marie-Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia. Pubmed

Read more: 20/04/2017

19/12/2016

Expanding previous work on the role of autotaxin in chronic inflammatory disorders that have led to phase II clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a novel, major role for this secreted lysophospholipase D in the pathogenesis of hepatitis and hepatocellular carcinoma. PubMed.

Read more: 19/12/2016

20/09/2016

Fleming Researcher Dr Antigone Dimas has been awarded an ERC Starting Grant to explore the complex biological impact of dietary intake in humans. This is the fourth ERC grant awarded to a Fleming Researcher in the past 5 years. The title of Dr Dimas's grant is "A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans”. 

Read more: 20/09/2016

16/06/2016

Recent work by Fleming researchers identifies a Wnt-regulated long non-coding RNA that controls intestinal stem cell fate and carcinogenesis. Pubmed

Read more: 16/06/2016

16/06/2016

Recent work by Fleming researchers uncovered a protein methylation-dependent control mechanism in the pathogenesis of pulmonary fibrosis. Pubmed

Read more: 16/06/2016

28/04/2016

Τhe 2011 Nobel Laureate in Physiology or Medicine, Prof. Bruce Beutler, will be visiting Fleming, on Tuesday May 24th, 2016, and at 12 noon, he will be discussing his life in science in an "Ask the Nobelist" Q&A session targeted to young scientists (open to the public). Prof. Beutler will also be giving inaugural addresses at the Academy of Athens on May 23rd, 2016 at 20:00 and the University of Athens on May 24th, 2016 at 19:00.

Read more: 28/04/2016

01/03/2016

Recent work by Fleming researchers demonstrates that the histone methyltransferase Smyd3 is required for the development of experimentally induced liver and colon cancer in mice. Pubmed

Read more: 01/03/2016

18/02/2016

The study by Fleming researchers highlighted in December 2015 (Koliaraki et al., J. Exp. Med. 2015) is featured in a “News & Views” article in Nature. The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.

09/12/2015

In an invited commentary by Nature Immunology (December 2015 issue), Fleming researcher George Kollias, and John Lambris (UPenn) propose “A ‘rule of 3’ to revive Greek science, research and innovation”. Pubmed

Read more: 09/12/2015

03/12/2015

In a new study published in J. Exp. Med., Fleming researchers show that IKKβ deletion in ColVI-expressing intestinal mesenchymal cells protects mice against inflammation-induced intestinal carcinogenesis,  revealing a hitherto unknown role of mesenchymal IKKβ in driving inflammation and enabling carcinogenesis in the intestine. Pubmed, commentary.

 

Read more: 03/12/2015

11/03/2015

Fleming Researcher Prof. George Kollias has been awarded the first Galien Scientific Research Award at the  Prix Galien Greece 2015. The prize recognizes his seminal contributions towards the development of biological therapies for rheumatoid arthritis and the discovery of novel disease pathways in animal models of chronic inflammation and autoimmunity. (Press release in Greek)

16/02/2015

The Biomedical Sciences Research Center "Alexander Fleming" is seeking independent researchers to establish their own laboratories, and Staff Scientists (ΕΛΕ) to lead and manage FLEMING’s research facilities/units. (PDF)

12/01/2015

Papanikolopoulou & Skoulakis demonstrate that Tau-mediated neuronal dysfunction and toxicity are separable and in fact neuronal dysfunction, which requires phosphorylation on Ser262, precedes and is required for Ser238 phosphorylation which in turn is requisite for premature lethality. PubMed

Read more: 12/01/2015

08/01/2015

Dr Antigone Dimas, Marie-Curie and EMBO Research Fellow at BSRC Alexander Fleming, was awarded this year’s L’Oréal-UNESCO Award for Women in Science. This prestigious award rewards promising young women scientists whose outstanding achievements have contributed to the advancement of scientific knowledge.

Read more: 08/01/2015

02/01/2015

Recent work by Fleming researchers indicate that in liver tumors, cancer stem cells may originate from differentiating ductal progenitors following oncogenic transformation. PubMed .

Read more: 02/01/2015

19/12/2014

Infrafrontier-GR/Phenotypos, the Greek Research Infrastructure for molecular and behavioural Phenotyping of biological model organisms for chronic degenerative diseases, which is coordinated by Fleming, has been included in the new National Roadmap for Research infrastructures that has just been launched by the General Secretariat for Research and Technology.

Read more: 19/12/2014

17/12/2014

The Induction Ceremony for Fleming researcher, Professor George Kollias, at the Academy of Athens took place on Tuesday, 11 November 2014 (Opening Lecture video – in Greek).

Read more: 17/12/2014

23/10/2014

In a study published this week in PNAS, Fleming researchers uncover a novel mechanism that exists to physiologically protect the intestinal epithelium against damage and when dysregulated, it may underlie the development of Inflammatory Bowel Diseases in humans. The study is highlighted in Nat. Rev. Gastroenterol. Hepatol. and Faculty of 1000.

Read more: 23/10/2014

17/10/2014

Work from Kontoyiannis Lab presented in Cell Death and Differentiation suggests that specific RNA-binding proteins (RBPs) of the Elavl family are required to confer protection from neurodegeneration.

Read more: 17/10/2014

28/08/2014

Work from Luca Turin, Efthimios Skoulakis and Andrew Horsfield just published in PNAS suggests that volatile anesthetics operate by perturbing the internal electronic structure of proteins.

Read more: 28/08/2014

27/08/2014

In a study published this week at the BMC Genomics journal researchers of the Division of Molecular Biology and Genetics and the FLEMING's Genomics Facility, in close collaboration with the University of Thessaly, helped to uncover a novel aspect of insecticide resistance in the olive fly, the most devastating pest of cultivated olives.

Read more: 27/08/2014

29/05/2014

International recognition of a molecular biology database developed in Greece. Diana-TarBase, the database of experimentally verified microRNA targets, is now part the widely used genome browser Ensembl.

Read more: 29/05/2014

09/05/2014

This year's Carol Nachman Prize for Rheumatology was awarded to BSRC Fleming researcher, biologist Prof. Dr. George Kollias.  The Prize is one of Germany's highest medical honours and the most prestigious international award for research in Rheumatology.

Read more: 09/05/2014

10/04/2014

The quality of the work performed at the Fleming Genomics Facility has recently been recognized in the Run RecognitION League of the Ion Community.

Read more: 10/04/2014

18/03/2014

600 graduate students and postdoctoral scientists are selected worldwide after nomination from scientists of their home countries to attend the yearly Lindau Nobel Laureates Meeting.

Read more: 18/03/2014

05/12/2013

FLEMING joins Infrafrontier GmbH. The Center is now a Founding Member of Infrafrontier GmbH, the managing entity of the European ESFRI Infrafrastructure INFRAFRONTIER.

Read more: 05/12/2013

25/10/2013

Fleming researcher Iannis Talianidis has been elected member of Academia Europaea. Earlier this year he was elected Foreign Member of the Hungarian Academy of Sciences.

Read more: 25/10/2013

16/10/2013

Novel osteoporosis models. In a study published this week at the Journal of Bone and Mineral Research (DOI: 10.1002/jbmr.2112) the research group of Eleni Douni and colleagues

Read more: 16/10/2013

27/09/2013

Fleming researcher Prof. George Kollias has been awarded an Advanced ERC grant, to tackle the role of mesenchymal cells (MC) in intestinal homeostasis during inflammatory and tumorigenic conditions

Read more: 27/09/2013

25/06/2013

Fighting cancer: FAK levels do matter. In a study published today at Nature Communication (DOI: 10.1038/ncomms3020), Fleming researcher Vassiliki Kostourou and colleagues demonstrated

Read more: 25/06/2013

15/05/2013

Tumor necrosis by TNF revisited: In a study published today at JCI, Fleming researchers, in collaboration with Ghent University, VIB and Biomedcode Hellas SA, uncouple the mechanisms

Read more: 15/05/2013

19/03/2013

In recognition of eminent scientific discoveries and contributions to science, Fleming researcher Professor George Kollias was elected March 14th 2013, full member of the Academy of Athens,

Read more: 19/03/2013

31/01/2013

A new study published in PLoSOne by the Turin and Skoulakis labs in collaboration with the local fragrance chemistry company Vioryl demontrates that humans can differentiate between

Read more: 31/01/2013

30/01/2013

In the context of Fleming's strategic plans for the creation of a "Biotechnopolis" in its premises, the Center participates in ESFRI Infrastructure INFRAFRONTIER, the European Infrastructure

Read more: 30/01/2013

29/10/2012

Fleming researchers have uncovered novel cancer modulating pathways acting in the mesenchymal microenvironment of colon tumors.

Read more: 29/10/2012

24/09/2012

In a paper marked as “must read” from the Journal of Neuroscience, the Skoulakis lab revealed a novel regulatory loop connecting metabotropic Glutamate Receptor, cAMP signalling and Fragile X Mental Retardation Protein.

Read more: 24/09/2012

13/07/2012

Fleming researcher receives ERC Starting/Consolidator Grant. Dr Maria Fousteri was awarded the prestigious ERC Starting/Consolidator Grant to study epigenetic mechanisms associated with DNA repair processes and with the pathogenesis of Cockayne syndrome.

Read more: 13/07/2012

06/07/2012

Fleming researchers have revealed a major role for Autotaxin (ATX, ENPP2) and its bioactive lipid product lysophosphatidic acid (LPA) in the pathogenesis of rheumatoid arthritis [Pubmed1] and pulmonary fibrosis [Pubmed2].

Read more: 06/07/2012

30/05/2012

Using miRNA profiling in synovial fibroblasts from an animal model of rheumatoid arthritis, Fleming researchers were able to predict novel miRNAs associated with the human disease.

Read more: 30/05/2012

30/01/2012

Using the EAE mouse model of Multiple Sclerosis (MS), Fleming researchers have uncovered the cellular basis of a pathologically significant role for TNFR2, the receptor of the proinflammatory cytokine TNF.

Read more: 30/01/2012

29/12/2011

Fleming Researchers (Kontoyiannis Group) revealed the importance of the mRNA regulator HuR, in inflammation supporting tumor development.

Read more: 29/12/2011

13/12/2011

Fleming researcher receives ERC Advanced Grant. Iannis Talianidis (Director of IMBG) was awarded the prestigious ERC Advanced Investigator Grant to study the function of histone modifying enzymes in disease.

Read more: 13/12/2011

17/11/2011

Fleming’s researchers have discovered a functional mutation in the mouse Rankl gene that causes Autosomal Recessive Osteopetrosis, a lethal inherited disorder in humans characterized by increased bone mass.

Read more: 17/11/2011

16/09/2011

Research in the Skoulakis lab identified the Receptor Tyrosine kinase Alk as essential for for manifestation of neurofibromatosis1, a common (1 in 3500 births) inherited disorder characterized by tumors of the nervous system, short stature and learning disabilities.

Read more: 16/09/2011

13/04/2011

BSRC Fleming participates in a EUR 38 million European investment project for research and innovation, funded by the EFPIA and the European Union under the Innovative Medicines Initiative (IMI) platform.

Read more: 13/04/2011

30/03/2011

Crohn's disease (CD) is a serious chronic inflammatory disease of the intestine but its causes remain largely unknown. The inflammatory molecule TNF plays a crucial role and therapies against TNF are successful in patients.

Read more: 30/03/2011

20/03/2011

5th International Course on Laboratory Animal Science. Vari, Greece, 19-30 September 2011. A two-week intensive course on laboratory animal science will be organized at the B.S.R.C Alexander Fleming–Vari, Greece in September 2011.

Read more: 20/03/2011

24/01/2011

Researchers at Fleming provide strong evidence that molecular vibrations of an odorant molecule contribute to its detection.

Read more: 24/01/2011

24/01/2011

Fleming Researchers report in “Molecular and Cellular Biology” journal the identification of some specific functions of the enzyme Dnmt3a1 in mouse Embryonic Stem cells.

Read more: 24/01/2011

19/10/2010

Fleming researchers discovered a dynamic interplay between posttranslational modifications of E2F1 that plays a decisive role in the activation of opposite biological pathways. [PubMed1] [PubMed2]

Read more: 19/10/2010

01/09/2010

Fleming researchers uncover how the Sox1 transcription factor regulates the size of the cortical neural progenitor cell pool in mice [PubMed1] and develop a safe and efficient metabolite-inducible gene expression system for basic research and biomedical applications [PubMed2].

Read more: 01/09/2010

16/01/2010

Fleming’s researchers have discovered that embryonic expression of Autotaxin, a secreted lysophospholipase D generating lysophosphatidic acid, is necessary for vascular branching morphogenesis and neural tube closure. [PubMed]

Read more: 16/01/2010

13/01/2010

Fleming’s researchers have shown that pan-neuronal accumulation of wild type and mutant Taus in the Drosophila Central Nervous System yielded specific and differential toxicity in the embryonic neuroblasts that generate the mushroom body neurons. [PubMed]

Read more: 13/01/2010

10/01/2010

Infrafrontier-GR Strategy Meeting, October 15, 2010, BSRC Fleming. BSRC Fleming is organizing a Strategy Meeting in the context of the National Research Infrastructure Infrafrontier-GR.

Read more: 10/01/2010

04/01/2010

International Course on Laboratory Animal Science IV. Vari, Greece, 4-15  October 2010. A two-week intensive course on laboratory animal science will be organized at the B.S.R.C Alexander Fleming–Vari, Greece in October 2010.

Read more: 04/01/2010

02/06/2009

Fleming's researchers have shown that the RNA-binding protein HuR controls T-cell maturation. As highlighted in the Journal of Immunology, Papadaki et al. demonstrated that HuR controls the cell cycle of immature progenitors as well as the antigenic, apoptotic and migration signals that guide T-cell maturation, deletion and egress.

Read more: 02/06/2009

28/04/2009

Fleming’s researchers have discovered a new role for the enzyme heme oxygenase (HO)-1. In their latest article in JEM they show that macrophages need HO-1 to incite inflammation upon viral infection through the antiviral cytokine IFN-β, identifying HO-1 as a new target in developing effective therapeutic interventions in a range of infectious and immune diseases.

Read more: 28/04/2009

24/03/2009

Post-transcriptional Regulators in Development: Fleming Researchers reveal the role of the AU-rich binding protein HuR in the post-transcriptional regulation of gene expression during placental morphogenesis, skeletal patterning and splenic development. [Pubmed]

Read more: 24/03/2009

10/03/2009

Registration is now open! 2nd International MUGEN Conference on Animal Models for Human Immunological Disease, 8-10 October, Athens, Greece MUGEN Workshop on Immune Mouse Phenotyping, 6-8 October 2009, Athens, Greece.

Read more: 10/03/2009

02/03/2009

International Course on Laboratory Animal Science III. Vari, Greece, 21 September-2 October 2009. A two-week intensive course on laboratory animal science will be organized at the B.S.R.C Alexander Fleming–Vari, Greece in September 2009.

Read more: 02/03/2009

26/02/2009

Fleming researchers have shown for the first time that an adaptor protein in neurons engages distinct signalling molecules and cascades for learning and memory formation, providing an experimental platform for exploration of human cognitive disorders that aftect RASRAF/MAPK signalling.

Read more: 26/02/2009

12/02/2009

Pulmonary translational research at Fleming: Researchers at the institute of immunology in collaboration with various University hospitals have discovered an important role for gelsolin, an actin-binding protein, in lung pathophysiology.

Read more: 12/02/2009

17/01/2009

Fleming researchers have discovered an important role for follicular dendritic cells (FDCs) in autoimmunity. Using a mouse model of arthritis, they found that FDCs were essential for autoantibody production through two distinct but cooperative functions.

Read more: 17/01/2009

30/10/2008

Chemoinformatics at Fleming: Fleming's researchers have used molecular modeling and chemoinformatics methods to derive relationships between chemical structure and biological activity of small-molecule antagonists of the CXCR3 receptor, a drug development target for chronic inflammatory diseases.

Read more: 30/10/2008

23/10/2008

BI Fleming Researchers in collaboration with the University of Crete have published a review that summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis;

Read more: 23/10/2008

23/10/2008

Bone Morphogenetic Proteins: From Local to Systemic Therapeutics’ summarizes recent advances made on the local and systemic use of BMPs.

Read more: 23/10/2008

16/09/2008

Researchers at the Institute of Molecular Biology and Genetics, identified neuralized as a gene preferentially expressed in the mushroom bodies, sites of associative learning and memory in insects and functionally equivalent to the vertebrate hippocampus/piriform cortex.

Read more: 16/09/2008

09/09/2008

Using a unique murine model for human Crohn’s disease, Fleming researchers identified key molecules that control T lymphocyte migration to the small intestine.

Read more: 09/09/2008

09/09/2008

International Course on Laboratory Animal Science, BSRC Al. Fleming, Athens, Greece. 22/9–3/10, 2008. A two-week intensive course on the basic facts and principles that are essential for the humane care and use of animals in the laboratory and research quality.

Read more: 09/09/2008

23/08/2008

Fleming researchers unraveled novel functions of the general transcription factor complex TFIID in regulating gene expression.

Read more: 23/08/2008

09/08/2008

Tumor cells in malignant pleural effusions (MPEs) are an important source of monocyte chemoattractant protein (MCP)-1.

Read more: 09/08/2008

01/08/2008

Inauguration of BSRC Fleming’s Expression Profiling Unit. The Unit is equipped with the most advanced technology on microarray experimentation and data analysis. The B.S.R.C. Al. Fleming’s Expression Profiling Unit provides expression profiling services to academic and research centers as well as the private sector.

Read more: 01/08/2008

20/07/2008

Fleming to coordinate the FP7 Marie Curie Initial Training Network “InteGeR” (2009-2012). The InteGeR (“Integrated Gene Regulation”) ITN aims at understanding gene regulatory mechanisms during cell differentiation by integrating studies from DNA binding by transcription factors, to epigenetics and nuclear organization.

Read more: 20/07/2008

16/05/2008

Researchers at the Institute of Molecular Oncology, BSRC Al. Fleming and their partners at the University of Pennsylvania and Ohio State University identified eight microRNAs located in chromosome 14 as potential tumor suppressors in Epithelial Ovarian Cancer (EOC).

Read more: 16/05/2008

05/05/2008

Researchers at the Institute of Immunology discover common cellular targets of Tumor Necrosis Factor, a key molecule involved in the pathogenesis of various arthritic and inflammatory bowel diseases. Please see related press release (English) and press release (Greek-VimaScience).

22/02/2008

Institute for Immunology, utilizing comparative expression profiling, have discovered new genes and pathways involved in the pathophysiology of pulmonary fibrosis.

Read more: 22/02/2008

22/11/2007

The MUGEN Mouse Database (MMdb) is a database of murine models of immune processes and immunological diseases.

Read more: 22/11/2007

10/10/2007

International Course on Laboratory Animal Science, Vari, Greece, 24 September - 5 October 2007 organized by BSRC Fleming.

Read more: 10/10/2007

10/10/2007

CASIMIR Network Meeting in Corfu (3rd-6th October) organized by BSRC Fleming. CASIMIR, a coordination action of the 6th Framework Programme of the European Commission, focuses on co-ordination, integration and sustainability of international mouse informatics resources.

Read more: 10/10/2007

27/02/2007

BSRC "Alexander Fleming" has recently published at PLoS One new work suggesting the use of soluble TNF inhibitors in the treatment of Idiopathic Pulmonary Fibrosis. (Press Release) (View PDF)

Read more: 27/02/2007

04/01/2007

BSRC Al. Fleming was recently appointed coordinator of MUGEN, a consortium of 24 European organizations constituting a Network of Excellence on 'Functional Genomics in mutant mouse models as tools to investigate the complexity of human immunological disease' (6th Framework Program, 2005-2009).

Read more: 04/01/2007

06/09/2006

For a second time in the last five years both our Institute of Immunology and the Institute of Molecular Biology and Genetics were evaluated as top of the list, "Excellent" research Institutes in Greece... more

Read more: 06/09/2006

05/06/2006

Research at the Institute of Immunology provided Don Cleveland?s group at the University of California at San Diego with transgenic tools (CD11b-Cre mice) to help in the analysis of disease mechanisms in a mouse model of Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease in humans.

Read more: 05/06/2006

05/01/2006

Researchers at the Institute for Immunology have uncovered a precise molecular mechanism by which follicular dendritic cells signal the formation of B cell follicles as well as B cell survival and maturation.

Read more: 05/01/2006

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