Fleming researchers have revealed that MAP3K8 (TPL2), a Ser/Thr MAP3K kinase, has a central role in the regulation of fibrotic responses in the lung. [PubMed]

Read more: 18/01/2021


recoup, a new software package by the Moulos lab, published in BMC Bioinformatics, allows for comprehensive and versatile visualization of summarized NGS signals. Backed by a small user-study, recoup’s purpose spans applications from routine quality control and visual hypothesis checks up to publication quality figures. [Pubmed], [DOI]

Read more: 08/01/2021


Α new study performed by Papanikolopoulou Lab, BSRC Alexander Fleming, published in Journal of Neuroscience, evidence that that the two cysteine residues of Tau protein are not functionally equivalent with respect to Tau biology and pathological potential. [Pubmed]

Read more: 28/12/2020


The “Fotis Kafatos” award for Excellence in Biology goes to BSRC Alexander Fleming young researchers!

Read more: 2/12/2020


Fleming retains its position as the top Greek research center in terms of publication impact in the Medical & Health Sciences.

Read more: 03/11/2020


BSRC Fleming researchers Marietta Armaka and George Kollias, in collaboration with Biomedcode, published a new study in Arthritis Research and Therapy, introducing the TgA86 transmembrane TNF transgenic mouse as a novel model of human spondyloarthritis (SpA). 

Read more: 16/10/2020


BSRC Fleming contributes to the fight against Covid-19.

Read more: 23/09/2020


Koliaraki, Armaka and Kollias laboratories published a review article in Nature Immunology on the contextual role of fibroblastic mesenchymal cells in physiology and disease. [Pubmed]

Read more: 04/09/2020


A new study by the Moulos lab reveals that combining RNA-Seq analysis algorithms not only improves accuracy, but shows robustness against different normalizations, alleviates downstream biases including gene-length bias in pathway analysis and improves long non-coding RNAs expression analysis. [Pubmed]

Read more: 01/09/2020


Verykokakis and colleagues revealed that the transcription factor BCL-6 controls early development of innate-like T cells, including Natural Killer T (NKT) and Mucosal-Associated Invariant T (MAIT) cells, in a new study, published in Nature Immunology.

Read more: 29/07/2020


Two Open Calls for proposals for (A) mouse model development and (B) mouse phenotyping services offered FREE OF CHARGE by the InfrafrontierGR/Phenotypos research infrastructure at BSRC Fleming.

Read more: 23/07/2020


BSRC Alexander Fleming joins in the National Plan for Open Science.

Read more: 10/07/2020


OPEN CALL for applications for the Institute for Bioinnovation Director position of the BSRC Alexander Fleming.
Deadline: 31 August 2020.

Read more: 24/06/2020


Α new collaborative study published in ‘Nature’ by George Kollias’ lab at BSRC Fleming and University of Athens, and Richard Flavell’s lab at Yale University, provides the first definitive in vivo evidence that the mesenchymal microenvironment of intestinal stem cells controls tumor initiation in the intestine. [Source], Press Release GR.

Read more: 02/04/2020


As the SARS-Cov-2 virus continues to spread, BSRC Fleming joins national and international efforts to combat it and offers its facilities, resources, expertise and specialised personnel to support research and diagnosis needs during the COVID-19 pandemic.
1st announcement (GR), (ENG).
UPDATED announcement (GR), (ENG).


OPEN CALL for applications for the Director position of the BSRC Alexander Fleming. Deadline: 25 May 2020.

Read more: 13/03/2020


BSRC A. Fleming participates in a new three-year collaborative H2020 project of €5 million budget, ELIXIR-CONVERGE, working on some of the major challenges in data access, provisioning and distribution.

Read more: 06/03/2020


Liakos, Konstantopoulos et al. new study conducted under the supervision of M Lavigne and M Fousteri revealed how maintaining transcription initiation at genes and regulatory regions during genotoxic stress recovery secures the integrity of the whole transcriptome [Nature Communications]

Read more: 18/02/2020


Koliaraki and Kollias laboratories published a review article in JEM that provides a concise overview of the relationship between the innate stroma and cancer, bringing into focus an emerging concept that sets the fibroblastic mesenchyme as a central player in shaping the tumor microenvironment. The innate stroma, encompassing innate immune as well as fibroblastic mesenchymal cells, acts as an important orchestrator of the cancer microenvironment and can influence tumor fate through anti- or pro-tumorigenic roles. [Pubmed]

Read more: 13/02/2020


A collaborative study involving advanced bioinformatics analyses conducted by Panagiotis Moulos, Stavros Niarchos researcher at BSRC Alexander Fleming and Iannis Talianidis lab at IMBB-FORTH provides evidence of chromatin bookmarking by the non-pioneer transcription factors C/EBPα and HNF4α which then is key to future gene activation during liver development. [Pubmed]

Read more: 06/02/2020


A new Frontiers E-book on “Pulmonary Fibrosis”, guest-edited by Fleming Researchers and distinguished leading experts, was recently published. The E-book comprises of 13 peer-reviewed articles published in the corresponding research topic, in the section of Pulmonary Medicine, Frontiers in Medicine [Frontiers].


Fleming researchers, in collaboration with GlaxoSmithKline and the London School of Hygiene and Tropical Medicine, developed a novel series of fast-kill agents against malaria. Chemoproteomic analysis also showed that the mechanism through which this fast-kill effect is exhibited is the inhibition of serine/arginine protein kinase 2 (SRPK2), thus rendering this target a tractable approach for developing antimalarial compounds with extremely fast-killing properties. [Pubmed]

Read more: 15/11/2019


Glentis et al., from the Dimas lab, uncover genetic risk variants for hereditary breast cancer in the first exome sequencing study to be conducted in the Greek population. The authors carried out exome sequencing on BSRC Alexander Fleming’s in-house NGS platform, in patients with hereditary breast cancer of unknown genetic aetiology and in their informative relatives. [Pubmed]

Read more: 06/11/2019


Custom bioinformatics analysis performed by Dr. Martin Reczko contributed to a new collaborative study that introduces a platform for bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation, associated with a wide range of human disorders, including Alzheimer’s and Parkinson’s disease. [Science Advances]

Read more: 29/10/2019


In a new publication from the Skoulakis lab in the Journal of Neuroscience, Roussou et al  provides conceptual, but also pharmacological links between habituation defects in Drosophila and particular schizophrenia symptoms in humans. [Pubmed]

Read more: 15/10/2019


Denaxa et al., describes how to genetically engineer young neurons, transplant them into the brain and study their impact on brain function. These methodologies are powerful tools for the design of cell transplantation therapies and exploring mechanisms of neurodevelopmental diseases. [Pubmed]

Read more: 08/10/2019


Α new study performed by Papanikolopoulou and Skoulakis Lab, BSRC Alexander Fleming, published in Journal of Neuroscience, evidence that Tau loss in Drosophila dynamically alters brain cytoskeletal dynamics and profoundly affects neuronal proteostasis and plasticity. [Pubmed]

Read more: 16/09/2019


A new collaborative research study in which Dr. Georgios Pavlopoulos’ team from BSRC Alexander Fleming actively participated, demonstrates that the Human microbiome churns out thousands of tiny novel proteins which may be involved in diverse functions that have not yet been identified. [Pubmed]

Read more: 02/09/2019


Marietta Armaka from BSRC Alexander Fleming, Geert Van Loo (VIB, Ghent) and Manolis Pasparakis (Uni. Cologne, co-ordinator) supervised a study published in Nature Cell Biology which identifies a new molecular mechanism causing rheumatoid arthritis. [Nature Cell Biology]

Read more: 13/05/2019


Kerdidani et al. from Tsoumakidou lab demonstrated that the Wnt1 oncoprotein signals paracrine on dendritic cells to silence chemokine genes and promote tumor immune escape.  In vivo RNA interference against Wnt1 activated anti-tumor immunity and halted tumor growth. [Pubmed]

Read more: 10/04/2019


OPEN CALL for applications for 2 Director positions for the newly inaugurated Institutes at the BSRC Fleming: the Institute for Basic Biomedical Research and the Institute for Bioinnovation. Deadline for applications: 6 May 2019.

Read more: 06/03/2019


Koliaraki et al. from the Kollias and Koliaraki labs demonstrate that innate sensing through mesenchymal TLR4/MyD88 signals promotes spontaneous intestinal tumorigenesis. Genetic deletion of TLR4 or MyD88 in IMCs led to altered molecular profiles and reduction of intestinal tumors in the APCmin model. [Pubmed]

Read more: 22/01/2019


Christodoulou-Vafeiadou and Ioakeimidis et al. in the Kontoyiannis lab showed that the ubiquitous RNA binding protein HuR has divergent roles in intestinal epithelial cells and myeloid-derived immune compartment in various models of intestinal inflammation and cancer. [PubMed]

Read more: 07/01/2019


Semelidou et al from the  Skoulakis lab demonstrated that distinct neuronal circuits mediate olfactory habituation latency and induction and proposed a novel role for the Lateral Horn, a neuropil innately encoding response valence to odor stimuli, in this process. [Pubmed]


Greece joins the European Research Infrastructure ELIXIR as a full Member. As an ELIXIR Member, the Greek Node of ELIXIR – coordinated by BSRC Fleming  - and the Greek bioinformatics community is now able to fully integrate into ELIXIR activities and collaborate with other ELIXIR Nodes. Press release.

Read more: 13/09/2018


Gouzi et al in the Skoulakis lab revealed a novel mechanism of activity-dependent constrain on long term memory formation, apparently by mediated autoactivation of the Receptor Tyrosine Kinase Alk. [PubMed].

Read more: 03/09/2018


BSRC Fleming and the Medical School of the National and Kapodistrian University of Athens will jointly organize the Graduate program in "Molecular Biomedicine: Mechanisms of Disease, Molecular and Cell Therapies, and Bio-innovation".


The Inauguration of the "Center for New Biotechnologies & Precision Medicine" was announced at a press conference held on 07.06.2018 at the University of Athens. Fleming is a key collaborating Institute in this initiative and partner of pMedGR, the Greek Research Infrastructure for Personalised Medicine, which forms the basis of the New Center.

Read more: 18/06/2018


In a recent study published in PNAS, PhD student Ana Henriques from the labs of Dr. George Kollias and Dr. Vasiliki Koliaraki revealed that the kinase MK2 through the activation of Hsp27 in intestinal mesenchymal cells/CAFs plays an essential role in the promotion of colorectal cancers. [Pubmed].

Read more: 06/06/2018


Expanding previous work on the role of autotaxin in chronic inflammatory disorders that has provided the scientific basis for phase IIb clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a role for this secreted lysophospholipase D in the pathogenesis of lung cancer [PubMed].

Read more: 09/05/2018


Fleming researchers, using a Spondyloarthritis (SpA) mouse model have found that Tnfr2 signaling is regulating polyarthritis and a newly identified heart valve stenosis, which is a common comorbidity of SpA in human patients. [PubMed], [JCI Highlight], [Correspondence].

Read more: 16/04/2018


Rheumatoid arthritis and Spondyloarthritis are accompanied by several comorbid pathologies in human patients, often involving heart, lung and intestinal pathologies. Using the TNF-driven model of murine arthritis, Fleming researchers recently revealed the co-occurrence of arthritis with valvular heart disease. [PubMed], [Editorial], [Correspondence].

Read more: 30/03/2018


Two Fleming doctoral students (Panagiotis Chouvardas and Rania Semelidou) have been selected to attend the prestigious 68th Lindau Nobel Laureate Meeting, following a nomination by the Onassis Foundation. This year’s Meeting is dedicated to Physiology and Medicine and will bring together 600 young scientists and a record 43 Nobel Laureates.

Read more: 06/03/2018


In a collaborative study published in Cell Reports, a Fleming Stavros Niarchos fellow uncovered a novel mechanism that determines the number of cortical interneurons in the brain. The research has important implications for improving the effectiveness of cell-based therapies for epilepsy syndromes. PubMed.

Read more: 15/02/2018


Fleming researchers uncovered a molecular interplay between survival and death pathways in synovial fibroblasts mediating modelled Rheumatoid Arthritis. Their results suggest that combinatorial targeting of the IKK2/RIPK3 axis in chronic polyarthritis will be advantageous over targeting either of these pathways alone. Nat Commun , PubMed, Research highlight in Nature Reviews Rheumatology.


In a collaborative study published in Nat Med, a Fleming Marie Curie Fellow revealed that aerosolized delivery of active Thyroid Hormone (TH) resolved pulmonary fibrosis in two mouse models through a mechanism that involved improvement of mitochondrial biogenesis and mitophagy in alveolar type II epithelial cells. PubMed.

Read more: 29/01/2018


A summary of the pioneering work in the Skoulakis and Turin labs demonstrating the contribution of odorant vibrations to odor character and identification as recently published appeared in Vima Science 21/01/2018. Pubmed.


Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins-exposed tissues, such as skin and lung, thus actively participating in lowering oncogenesis. Nat Com.


On behalf of the Scientists and Personnel of BSRC Fleming I would like to express our sadness for the loss of Fotis Kafatos, an innovative mind that has influenced and shaped the development of Molecular Biology in Europe and in Greece. We extend our condolences to his family and the many students and colleagues he inspired through the years. 
George Kollias, President and Director of BSRC Fleming.



Recently published work from the Skoulakis lab suggests that cortical actin rearrangements underlie the little understood Anesthesia Resistant Memory, whose molecular mechanisms remained mysterious to date. Pubmed

Read more: 27/10/2017


The Genomics Facility of the BSRC Alexander Fleming, in collaboration with the lab of Iannis Talianidis, has developed a new high-throughput method for sequencing nascent RNAs labeled in vivo.

Read more: 27/07/2017


BSRC Fleming has signed a MoU with the National Bank of Greece sharing the common vision of fostering innovation and entrepreneurship in emerging areas of modern research. This partnership aims to contribute to the translation of scientific achievements into clinical practice and the development of innovative products of high added value. Press Release (in Greek).

Read more: 20/07/2017


Work by Fleming researchers has revealed that omic profiles of synovial fibroblasts from the Tg197 human TNF-transgenic model of arthritis greatly mimic human synovial fibroblast profiles from Rheumatoid arthritis patients, revealing commonly represented pathways that may constitute potential targets for future therapies (Pubmed, Editorial)

Read more: 12/05/2017


Fleming researchers have identified two new dual inhibitors of TNF and RANKL, two key factors involved in inflammatory processes. These inhibitors can be further optimized to develop improved treatments for a range of inflammatory, autoimmune, and bone loss diseases (PubMed, Ηighlights in international press).

Read more: 12/05/2017


Following a Forward Genetics approach, Fleming researchers identified a novel neurological mouse model caused by a functional mutation in the Slc25a46 gene, a new pathogenic target in a wide spectrum of human neurological diseases, including optic atrophy, Charcot-Marie-Tooth type 2, Leigh syndrome, progressive myoclonic ataxia and lethal congenital pontocerebellar hypoplasia. Pubmed

Read more: 20/04/2017


Expanding previous work on the role of autotaxin in chronic inflammatory disorders that have led to phase II clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a novel, major role for this secreted lysophospholipase D in the pathogenesis of hepatitis and hepatocellular carcinoma. PubMed.

Read more: 19/12/2016


Fleming Researcher Dr Antigone Dimas has been awarded an ERC Starting Grant to explore the complex biological impact of dietary intake in humans. This is the fourth ERC grant awarded to a Fleming Researcher in the past 5 years. The title of Dr Dimas's grant is "A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans”. 

Read more: 20/09/2016


Recent work by Fleming researchers identifies a Wnt-regulated long non-coding RNA that controls intestinal stem cell fate and carcinogenesis. Pubmed

Read more: 16/06/2016


Recent work by Fleming researchers uncovered a protein methylation-dependent control mechanism in the pathogenesis of pulmonary fibrosis. Pubmed

Read more: 16/06/2016


Τhe 2011 Nobel Laureate in Physiology or Medicine, Prof. Bruce Beutler, will be visiting Fleming, on Tuesday May 24th, 2016, and at 12 noon, he will be discussing his life in science in an "Ask the Nobelist" Q&A session targeted to young scientists (open to the public). Prof. Beutler will also be giving inaugural addresses at the Academy of Athens on May 23rd, 2016 at 20:00 and the University of Athens on May 24th, 2016 at 19:00.

Read more: 28/04/2016


Recent work by Fleming researchers demonstrates that the histone methyltransferase Smyd3 is required for the development of experimentally induced liver and colon cancer in mice. Pubmed

Read more: 01/03/2016


The study by Fleming researchers highlighted in December 2015 (Koliaraki et al., J. Exp. Med. 2015) is featured in a “News & Views” article in Nature. The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.


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