Expanding previous work on the role of autotaxin in chronic inflammatory disorders that have led to phase II clinical trials in idiopathic pulmonary fibrosis, Fleming researchers have now uncovered a novel, major role for this secreted lysophospholipase D in the pathogenesis of hepatitis and hepatocellular carcinoma. PubMed.
Fleming Researcher Dr Antigone Dimas has been awarded an ERC Starting Grant to explore the complex biological impact of dietary intake in humans. This is the fourth ERC grant awarded to a Fleming Researcher in the past 5 years. The title of Dr Dimas's grant is "A genomics and systems biology approach to explore the molecular signature and functional consequences of long-term, structured fasting in humans”.
Τhe 2011 Nobel Laureate in Physiology or Medicine, Prof. Bruce Beutler, will be visiting Fleming, on Tuesday May 24th, 2016, and at 12 noon, he will be discussing his life in science in an "Ask the Nobelist" Q&A session targeted to young scientists (open to the public). Prof. Beutler will also be giving inaugural addresses at the Academy of Athens on May 23rd, 2016 at 20:00 and the University of Athens on May 24th, 2016 at 19:00.
The study by Fleming researchers highlighted in December 2015 (Koliaraki et al., J. Exp. Med. 2015) is featured in a “News & Views” article in Nature. The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.
In a new study published in J. Exp. Med., Fleming researchers show that IKKβ deletion in ColVI-expressing intestinal mesenchymal cells protects mice against inflammation-induced intestinal carcinogenesis, revealing a hitherto unknown role of mesenchymal IKKβ in driving inflammation and enabling carcinogenesis in the intestine. Pubmed, commentary.
Fleming Researcher Prof. George Kollias has been awarded the first Galien Scientific Research Award at the Prix Galien Greece 2015. The prize recognizes his seminal contributions towards the development of biological therapies for rheumatoid arthritis and the discovery of novel disease pathways in animal models of chronic inflammation and autoimmunity. (Press release in Greek)
Papanikolopoulou & Skoulakis demonstrate that Tau-mediated neuronal dysfunction and toxicity are separable and in fact neuronal dysfunction, which requires phosphorylation on Ser262, precedes and is required for Ser238 phosphorylation which in turn is requisite for premature lethality. PubMed
Dr Antigone Dimas, Marie-Curie and EMBO Research Fellow at BSRC Alexander Fleming, was awarded this year’s L’Oréal-UNESCO Award for Women in Science. This prestigious award rewards promising young women scientists whose outstanding achievements have contributed to the advancement of scientific knowledge.
Infrafrontier-GR/Phenotypos, the Greek Research Infrastructure for molecular and behavioural Phenotyping of biological model organisms for chronic degenerative diseases, which is coordinated by Fleming, has been included in the new National Roadmap for Research infrastructures that has just been launched by the General Secretariat for Research and Technology.
In a study published this week in PNAS, Fleming researchers uncover a novel mechanism that exists to physiologically protect the intestinal epithelium against damage and when dysregulated, it may underlie the development of Inflammatory Bowel Diseases in humans. The study is highlighted in Nat. Rev. Gastroenterol. Hepatol. and Faculty of 1000.
In a study published this week at the BMC Genomics journal researchers of the Division of Molecular Biology and Genetics and the FLEMING's Genomics Facility, in close collaboration with the University of Thessaly, helped to uncover a novel aspect of insecticide resistance in the olive fly, the most devastating pest of cultivated olives.
Research in the Skoulakis lab identified the Receptor Tyrosine kinase Alk as essential for for manifestation of neurofibromatosis1, a common (1 in 3500 births) inherited disorder characterized by tumors of the nervous system, short stature and learning disabilities.
Fleming researchers uncover how the Sox1 transcription factor regulates the size of the cortical neural progenitor cell pool in mice [PubMed1] and develop a safe and efficient metabolite-inducible gene expression system for basic research and biomedical applications [PubMed2].
Fleming's researchers have shown that the RNA-binding protein HuR controls T-cell maturation. As highlighted in the Journal of Immunology, Papadaki et al. demonstrated that HuR controls the cell cycle of immature progenitors as well as the antigenic, apoptotic and migration signals that guide T-cell maturation, deletion and egress.
Fleming’s researchers have discovered a new role for the enzyme heme oxygenase (HO)-1. In their latest article in JEM they show that macrophages need HO-1 to incite inflammation upon viral infection through the antiviral cytokine IFN-β, identifying HO-1 as a new target in developing effective therapeutic interventions in a range of infectious and immune diseases.
Post-transcriptional Regulators in Development: Fleming Researchers reveal the role of the AU-rich binding protein HuR in the post-transcriptional regulation of gene expression during placental morphogenesis, skeletal patterning and splenic development. [Pubmed]
Fleming researchers have shown for the first time that an adaptor protein in neurons engages distinct signalling molecules and cascades for learning and memory formation, providing an experimental platform for exploration of human cognitive disorders that aftect RASRAF/MAPK signalling.
Chemoinformatics at Fleming: Fleming's researchers have used molecular modeling and chemoinformatics methods to derive relationships between chemical structure and biological activity of small-molecule antagonists of the CXCR3 receptor, a drug development target for chronic inflammatory diseases.
BI Fleming Researchers in collaboration with the University of Crete have published a review that summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, neurite outgrowth and neurogenesis;
Researchers at the Institute of Molecular Biology and Genetics, identified neuralized as a gene preferentially expressed in the mushroom bodies, sites of associative learning and memory in insects and functionally equivalent to the vertebrate hippocampus/piriform cortex.
International Course on Laboratory Animal Science, BSRC Al. Fleming, Athens, Greece. 22/9–3/10, 2008. A two-week intensive course on the basic facts and principles that are essential for the humane care and use of animals in the laboratory and research quality.
Inauguration of BSRC Fleming’s Expression Profiling Unit. The Unit is equipped with the most advanced technology on microarray experimentation and data analysis. The B.S.R.C. Al. Fleming’s Expression Profiling Unit provides expression profiling services to academic and research centers as well as the private sector.
Fleming to coordinate the FP7 Marie Curie Initial Training Network “InteGeR” (2009-2012). The InteGeR (“Integrated Gene Regulation”) ITN aims at understanding gene regulatory mechanisms during cell differentiation by integrating studies from DNA binding by transcription factors, to epigenetics and nuclear organization.
Researchers at the Institute of Molecular Oncology, BSRC Al. Fleming and their partners at the University of Pennsylvania and Ohio State University identified eight microRNAs located in chromosome 14 as potential tumor suppressors in Epithelial Ovarian Cancer (EOC).
CASIMIR Network Meeting in Corfu (3rd-6th October) organized by BSRC Fleming. CASIMIR, a coordination action of the 6th Framework Programme of the European Commission, focuses on co-ordination, integration and sustainability of international mouse informatics resources.
BSRC Al. Fleming was recently appointed coordinator of MUGEN, a consortium of 24 European organizations constituting a Network of Excellence on 'Functional Genomics in mutant mouse models as tools to investigate the complexity of human immunological disease' (6th Framework Program, 2005-2009).
Research at the Institute of Immunology provided Don Cleveland?s group at the University of California at San Diego with transgenic tools (CD11b-Cre mice) to help in the analysis of disease mechanisms in a mouse model of Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease in humans.