Two works, by Antonis Klonizakis and Sofia Papanikolaou from the Computational Genomics Group (Nikolaou lab) win full and short talk awards respectively, in the 15th Annual Meeting of the Hellenic Society for Computational Biology and Bioinformatics.
Molecular condensates are formed through the aggregation of potent enhancers in nuclear entities with increased transcriptional activity that are phase-separated from the rest of the nucleoplasm. The method developed by Antonis Klonizakis combines information from expression, epigenetic and chromatin data and provides a promising framework for the study of the sequence of events in the transdifferentiation of B-cells to macrophages. A. Klonizakis won the best full talk award (a travel grant of 500€).
Sofia Papanikolaou’s work has focused on the prevalence of transcriptional changes in whole blood cells of SLE patients that are associated with alternative splicing. We detect a number of intron retention events, during which, large introns are included in processed transcripts and likely lead them for non-sense mediated decay, thus adding an additional layer of post-transcriptional regulation in SLE. S. Papanikolaou won the best short talk award (a travel grant of 300€).