The Koliaraki lab published a new study in Cellular and Molecular Life Sciences on the role of mesenchymal cells in intestinal morphogenesis and homeostasis.
A new study published in Cellular and Molecular Life Sciences by the Koliaraki lab in collaboration with the Kollias lab revealed the role of Col6a1+/CD201+ mesenchymal cells in intestinal morphogenesis and homeostasis.
Intestinal mesenchymal cells encompass multiple subsets, whose origins, functions, and pathophysiological importance are still not clear.
In a new study published in Cellular and Molecular Life Sciences, entitled “Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis”, Koliaraki and colleagues described the properties and identities of Col6a1-cre lineage colonic intestinal mesenchymal cells, which include PDGFRαhi fibroblasts and perivascular cells, defined their ontogenic relationship with mesenchymal clusters during embryonic development and identified their role as orchestrators of intestinal morphogenesis and regulators of epithelial homeostasis.
Moreover, compensatory proliferation along with topological and functional alterations of CD34+ mesenchymal cells following depletion of Col6a1-cre lineage cells further supported the concept of mesenchymal plasticity both during homeostasis and tissue repair.
Melissari, MT., Henriques, A., Tzaferis, C., Prados A., Sarris M.E., Chalkidi N., Mavroeidi D., Chouvardas P., Grammenoudi S., Kollias G., Koliaraki V. Col6a1+/CD201+ mesenchymal cells regulate intestinal morphogenesis and homeostasis. Cell. Mol. Life Sci. 79, 1 (2022). https://doi.org/10.1007/s00018-021-04071-7 [Pubmed]
Read the full text in Sharedit: https://rdcu.be/cDi7D