Publications

1. Boj S. F., van Es J. H., Huch M., Li V., José A., Hatzis P., Mokry M., Haegebarth A., van den Born M., Chambon P., Voshol P., Dor Y., Cuppen E., Fillat C., Clevers H. (2012) Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell Dec. 21; 151(7):1595-607

2. Mokry M.*, Hatzis P. *, Schuijers J. *, Lansu N., Ruzius F. P., Clevers H., Cuppen E. (2012) RNA polymerase II DNA occupancy as a measure of gene activity. Nucleic Acids Res. Jan;40(1) 148-58

3. Mokry M., Hatzis P., de Bruijn E., Guryev V., Koster J., Versteeg R., Schuijers J., van de Wetering M., Clevers H., Cuppen E. (2010) Double fragmentation ChIP-seq provides single nucleotide resolution of Tcf4 binding characteristics. PloS One Nov 30;5(11):e15092

4. Mahmoudi T., Boj S.F., Hatzis P., Li V.S.W., Taouatas N., Vrie R.G.J., Teunissen H., Begthel H., Korving J., Mohammed S., Heck A.J.R., Clevers H. (2010) The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biology, PLoS Biol. Nov 16;8(11):e1000539

5. Verzi M.P., Hatzis P., Sulahian R., Philips J., Schuijers J., Shin H., Freed E., Lynch J.P., Dang D.T., Brown M., Clevers H., Liu X.S., Shivdasani R.A. (2010) TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. PNAS 107(34): 15157-62

6. Sue Ng S., Mahmoudi T., Li V.S., Hatzis P., Boersema P.J., Mohammed S., Heck A.J., Clevers H. (2010) MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biol Chem. 391(2-3): 171-80

7. van der Flier L.G., van Gijn M.E., Hatzis P., Kujala P., Haegebarth A., Stange D.E., Begthel H., van den Born M., Guryev V., Oving I., van Es J.H., Barker N., Peters P.J., van de Wetering M., Clevers H. (2009) Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 136(5): 903-12

8. Armand A.S., Bourajjaj M., Martínez-Martínez S., el Azzouzi H., da Costa Martins P.A., Hatzis P., Seidler T., Redondo J.M., De Windt L.J. (2008) Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem. 283(43):29004-10

9. Hatzis P., van der Flier L.G., van Driel M.A., Guryev V., Nielsen F., Denissov S., Nijman I.J., Koster J., Santo E.E., Welboren W., Versteeg R., Cuppen E., van de Wetering M., Clevers H., Stunnenberg H.G. (2008) Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 28(8): 2732-44

10. Hatzis, P., Kyrmizi, I., Talianidis, I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. Mol Cell Biol. 26(19): 7017-29

11. Kyrmizi I., Hatzis P., Katrakili N., Tronche F., Gonzalez F.J., Talianidis I. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20(16): 2293-305

12. van Es J.H., Jay P., Gregorieff A., van Gijn M.E., Jonkheer S., Hatzis P., Thiele A., van den Born M., Begthel H., Brabletz T., Taketo M.M., Clevers H. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol. 7(4): 381-6

13. Hatzis P., Talianidis I. (2002) Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol Cell. 10(6): 1467-77

14. Hatzis P., Talianidis I. (2001) Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression. Mol Cell Biol. 21(21): 7320-30.

15. Conlan R.S., Gounalaki N., Hatzis P., Tzamarias D. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co- activator. J Biol Chem. 274(1): 205-10

16. Hatzis P., Al-Madhoon A.S., Jüllig M., Petrakis T.G., Eriksson S., Talianidis I. (1998) The intracellular localization of deoxycytidine kinase. J Biol Chem. 273(46): 30239-43

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