We are investigating Wnt-dependent transcriptional regulation in the intestine and liver and its contribution to normal homeostasis and carcinogenesis. By using high-throughput techniques, such as ChIP- and RNA-seq and proteomic approaches, we are interested in:

  1. identifying and characterizing novel protein modulators of TCF4/β-catenin, the transcription complex at the endpoint of the pathway
  2. identifying noncoding RNA targets of the Wnt-pathway and exploring their contribution in Wnt-dependent transcriptional responses
  3. investigating the functional interplay between the Wnt-pathway and other intestine- and liver-enriched transcription factors in the regulation of tissue-specific transcriptional responses.

B.S.R.C. "Alexander Fleming"
34 Fleming Street, 16672 Vari, Greece
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