Marietta Armaka Research Group

Publications

  1.  Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components.

Roumelioti F, Tzaferis C, Konstantopoulos D, Papadopoulou D, Prados A, Sakkou M, Liakos A, Chouvardas P, Meletakos T, Pandis Y, Karagianni N, Denis MC, Fousteri M, Armaka M, Kollias G.

Elife. 2024 Sep 5;13:e84698. doi: 10.7554/eLife.84698.

  1.  Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis.

Rinotas V, Iliaki K, Pavlidi L, Meletakos T, Mosialos G, Armaka M.

Cell Death Dis. 2024 Aug 9;15(8):584. doi: 10.1038/s41419-024-06966-2.

  1.  The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis.

Elhai M, Micheroli R, Houtman M, Mirrahimi M, Moser L, Pauli C, Bürki K, Laimbacher A, Kania G, Klein K, Schätzle P, Frank Bertoncelj M, Edalat SG, Keusch L, Khmelevskaya A, Toitou M, Geiss C, Rauer T, Sakkou M, Kollias G, Armaka M, Distler O, Ospelt C.

Nat Commun. 2023 Dec 9;14(1):8172. doi: 10.1038/s41467-023-44053-w.

  1.   A20 controls RANK-dependent osteoclast formation and bone physiology.

Martens A, Hertens P, Priem D, Rinotas V, Meletakos T, Gennadi M, Van Hove L, Louagie E, Coudenys J, De Muynck A, Gaublomme D, Sze M, van Hengel J, Catrysse L, Hoste E, Zajac JD, Davey RA, Van Hoorebeke L, Hochepied T, Bertrand MJM, Armaka M, Elewaut D, van Loo G.
EMBO Rep. 2022 Dec 6;23(12):e55233. doi: 10.15252/embr.202255233.

  1.   Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis.

Armaka M*#, Konstantopoulos D#, Tzaferis C#, Lavigne MD, Sakkou M, Liakos A, Sfikakis PP, Dimopoulos MA, Fousteri M*, Kollias G*.
(*Co-corresponding authors, # equal first co-authors)

Genome Med. 2022 Jul 26;14(1):78. doi: 10.1186/s13073-022-01081-3.

  1.  'SMASH' recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models.

Hayer S, Vervoordeldonk MJ, Denis MC, Armaka M, Hoffmann M, Bäcklund J, Nandakumar KS, Niederreiter B, Geka C, Fischer A, Woodworth N, Blüml S, Kollias G, Holmdahl R, Apparailly F, Koenders MI.
Ann Rheum Dis. 2021 Feb 18;80(6):714-26. doi: 10.1136/annrheumdis-2020-219247. PMID: 33602797

  1.  Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis.

Christodoulou-Vafeiadou E, Geka C, Ntari L, Kranidioti K, Argyropoulou E, Meier F, Armaka M, Mourouzis I, Pantos C, Rouchota M, Loudos G, Denis MC, Karagianni N, Kollias G.
Arthritis Res Ther. 2020 Oct 6;22(1):232. doi: 10.1186/s13075-020-02327-4.PMID: 33023659 

  1.  The mesenchymal context in inflammation, immunity and cancer.

Koliaraki V, Prados A, Armaka M, Kollias G.Nat Immunol. 2020 Sep;21(9):974-982. doi: 10.1038/s41590-020-0741-2. Epub 2020 Aug 3.PMID: 32747813 Review.

  1.  Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis.

Kaaij MH, van Tok MN, Blijdorp IC, Ambarus CA, Stock M, Pots D, Knaup VL, Armaka M, Christodoulou-Vafeiadou E, van Melsen TK, Masdar H, Eskes HJPP, Yeremenko NG, Kollias G, Schett G, Tas SW, van Duivenvoorde LM, Baeten DLP.
J Exp Med. 2020 Oct 5;217(10):e20200288. doi: 10.1084/jem.20200288.PMID: 32662821 

10.         Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.

Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G.

Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. Epub 2020 Mar 16.

11.         A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M*, van Loo G*, Pasparakis M*.

(*jointly supervised the study)

Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3.

(highlighted in foreign and Greek media (Medical News Today, GEN, MedicalXpress, Technology Networks, Kathimerini.gr, Vima Science, healthmag.gr etc))

12.         Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.

Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT.

Elife. 2019 May 29;8. pii: e45571. doi: 10.7554/eLife.45571.

13.         RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.

Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V.

Cell Death Differ. 2019 Apr 15. doi: 10.1038/s41418-019-0330-9.

  1.  The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.

Armaka M*, Ospelt C, Pasparakis M, Kollias G*.
(*Co-corresponding authors)

Nat Commun. 2018 Feb 12;9(1):618. doi: 10.1038/s41467-018-02935-4.

(Research highlight in Nature Reviews Rheumatology)

  1.  Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.

Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G.

Sci Rep. 2017 May 25;7(1):2397. doi: 10.1038/s41598-017-02581-8.

  1.  Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions.

Frank-Bertoncelj M, Trenkmann M, Klein K, Karouzakis E, Rehrauer H, Bratus A, Kolling C, Armaka M, Filer A, Michel BA, Gay RE, Buckley CD, Kollias G, Gay S, Ospelt C.

Nat Commun. 2017 Mar 23;8:14852. doi: 10.1038/ncomms14852.

  1.  Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.

Wroblewski R*, Armaka M*, Kondylis V, Pasparakis M, Walczak H, Mittrücker HW, Schramm C, Lohse AW, Kollias G, Ehlken H.

(*equal first authors)

Hepatology. 2016 Aug;64(2):508-21. doi: 10.1002/hep.28551. Epub 2016 Apr 18.

  1.  RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.

Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T, Takayanagi H.

Ann Rheum Dis. 2016 Jun;75(6):1187-95. doi: 10.1136/annrheumdis-2014-207137. Epub 2015 May 29.

  1.  Host and microbiota interactions are critical for development of murine Crohn's-like ileitis.

Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado GC, Lira SA, Kollias G.

Mucosal Immunol. 2016 May;9(3):787-97. doi: 10.1038/mi.2015.102.

  1.  Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications.

Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, Szondy Z.

J Immunol. 2016 Feb 1;196(3):1146-57. doi: 10.4049/jimmunol.1501573.

  1.  Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells.

Jacques P, Lambrecht S, Verheugen E, Pauwels E, Kollias G, Armaka M, Verhoye M, Van der Linden A, Achten R, Lories RJ, Elewaut D.

Ann Rheum Dis. 2014 Feb;73(2):437-45. doi: 10.1136/annrheumdis-2013-203643.

  1.  Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.

Van Hauwermeiren F*, Armaka M*, Karagianni N*, Kranidioti K, Vandenbroucke RE, Loges S, Van Roy M, Staelens J, Puimège L, Palagani A, Berghe WV, Victoratos P, Carmeliet P, Libert C, Kollias G.
(*equal first authors)

J Clin Invest. 2013 Jun;123(6):2590-603. doi: 10.1172/JCI65624.

  1.  Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.

Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V.

J Exp Med. 2012 May 7;209(5):925-33. doi: 10.1084/jem.20112012.

  1.  Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.

Roulis M, Armaka M, Manoloukos M, Apostolaki M, Kollias G.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5396-401. doi: 10.1073/pnas.1007811108.

  1.  A standardized protocol for the isolation and culture of normal and arthritogenic murine synovial fibroblasts

Armaka M, Gkretsi V, Kontoyiannis D and Kollias G

Nature Protocols Network (2009) doi:10.1038/nprot.2009.102

  1.  Cellular mechanisms of TNF function in models of inflammation and autoimmunity.

Apostolaki M, Armaka M, Victoratos P, Kollias G.

Curr Dir Autoimmun. 2010;11:1-26. doi: 10.1159/000289195. Review.

  1.  Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.

Armaka M, Apostolaki M, Jacques P, Kontoyiannis DL, Elewaut D, Kollias G.

J Exp Med. 2008 Feb 18;205(2):331-7. doi: 10.1084/jem.20070906.

  1.  MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G; Mugen NoE consortium.

Nucleic Acids Res. 2008 Jan;36(Database issue):D1048-54. doi: 10.1093/nar/gkm838.

  1.  Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.

Vasilopoulos Y, Gkretsi V, Armaka M, Aidinis V, Kollias G.

Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii23-8. doi: 10.1136/ard.2007.079822. Review.

  1.  Functional genetic and genomic analysis of modeled arthritis.

Douni E, Armaka M, Kontoyiannis DL, Kollias G.

Adv Exp Med Biol. 2007;602:33-42. doi: 10.1007/978-0-387-72009-8_4. Review.

  1.  Generation and characterization of p38beta (MAPK11) gene-targeted mice.

Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, Darragh J, McIlrath J, Carr JM, Armit LJ, Clacher C, Malone L, Kollias G, Arthur JS.

Mol Cell Biol. 2005 Dec;25(23):10454-64. doi: 10.1128/MCB.25.23.10454-10464.2005.

  1.  Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.

Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Möller S, Waki K, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y, Kollias G.

PLoS Genet. 2005 Oct;1(4):e48. doi: 10.1371/journal.pgen.0010048.

  1.  Functional analysis of an arthritogenic synovial fibroblast.

Aidinis V, Plows D, Haralambous S, Armaka M, Papadopoulos P, Kanaki MZ, Koczan D, Thiesen HJ, Kollias G.

Arthritis Res Ther. 2003;5(3):R140-57. doi: 10.1186/ar749.

  1.  Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.

Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G.

J Exp Med. 2002 Dec 16;196(12):1563-74. doi: 10.1084/jem.20020281.

  1.  Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1.

Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M.

Antiviral Res. 1999 Sep;43(2):79-92. doi: 10.1016/s0166-3542(99)00036-4.