Publications

1.                   Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.

Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G.

Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. Epub 2020 Mar 16.

2.                   A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M*, van Loo G*#, Pasparakis M*#

(*jointly supervised the study; #co-corresponding authors)

Nat Cell Biol. 2019 Jun;21(6):731-742. doi: 10.1038/s41556-019-0324-3.

·         highlighted in foreign and Greek media (Medical News Today, GEN, MedicalXpress, Technology Networks, Kathimerini.gr, Vima Science, healthmag.gr etc)

3.    Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.

Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT.

Elife. 2019 May 29;8. pii: e45571. doi: 10.7554/eLife.45571.

4.                   RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.

Krishna-Subramanian S, Singer S, Armaka M, Banales JM, Holzer K, Schirmacher P, Walczak H, Kollias G, Pasparakis M, Kondylis V.

Cell Death Differ. 2019 Apr 15. doi: 10.1038/s41418-019-0330-9.

5.    The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.

Armaka M*, Ospelt C, Pasparakis M, Kollias G.*
(Co-corresponding authors)

Nat Commun. 2018 Feb 12;9(1):618. doi: 10.1038/s41467-018-02935-4.

(Research highlight in Nature Reviews Rheumatology)

6.    Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.

Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, Brachthäuser L, Calzada-Wack J, Horsch M, Beckers J, Rathkolb B, Adler T, Neff F, Wolf E, Gailus-Durner V, Fuchs H, de Angelis MH, Kollias G.

Sci Rep. 2017 May 25;7(1):2397. doi: 10.1038/s41598-017-02581-8.

7.    Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions.

Frank-Bertoncelj M, Trenkmann M, Klein K, Karouzakis E, Rehrauer H, Bratus A, Kolling C, Armaka M, Filer A, Michel BA, Gay RE, Buckley CD, Kollias G, Gay S, Ospelt C.

Nat Commun. 2017 Mar 23;8:14852. doi: 10.1038/ncomms14852.

8.    Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.

Wroblewski R*, Armaka M*, Kondylis V, Pasparakis M, Walczak H, Mittrücker HW, Schramm C, Lohse AW, Kollias G, Ehlken H.

(*equal contributors)

Hepatology. 2016 Aug;64(2):508-21. doi: 10.1002/hep.28551. Epub 2016 Apr 18.

9.    RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.

Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T, Takayanagi H.

Ann Rheum Dis. 2016 Jun;75(6):1187-95. doi: 10.1136/annrheumdis-2014-207137. Epub 2015 May 29.

10.Host and microbiota interactions are critical for development of murine Crohn's-like ileitis.

Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado GC, Lira SA, Kollias G.

Mucosal Immunol. 2016 May;9(3):787-97. doi: 10.1038/mi.2015.102. Epub 2015 Oct 21.

11.Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications.

Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, Szondy Z.

J Immunol. 2016 Feb 1;196(3):1146-57. doi: 10.4049/jimmunol.1501573. Epub 2016 Jan 4.

12.Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells.

Jacques P, Lambrecht S, Verheugen E, Pauwels E, Kollias G, Armaka M, Verhoye M, Van der Linden A, Achten R, Lories RJ, Elewaut D.

Ann Rheum Dis. 2014 Feb;73(2):437-45. doi: 10.1136/annrheumdis-2013-203643. Epub 2013 Aug 6.

13.Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium.

Van Hauwermeiren F*, Armaka M*, Karagianni N*, Kranidioti K, Vandenbroucke RE, Loges S, Van Roy M, Staelens J, Puimège L, Palagani A, Berghe WV, Victoratos P, Carmeliet P, Libert C, Kollias G.
(
*equal contributors)

J Clin Invest. 2013 Jun;123(6):2590-603. doi: 10.1172/JCI65624. Epub 2013 May 15.

14.Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.

Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V.

J Exp Med. 2012 May 7;209(5):925-33. doi: 10.1084/jem.20112012. Epub 2012 Apr 9.

15.Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology.

Roulis M, Armaka M, Manoloukos M, Apostolaki M, Kollias G.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5396-401. doi: 10.1073/pnas.1007811108. Epub 2011 Mar 14.

16.Cellular mechanisms of TNF function in models of inflammation and autoimmunity.

Apostolaki M, Armaka M, Victoratos P, Kollias G.

Curr Dir Autoimmun. 2010;11:1-26. doi: 10.1159/000289195. Epub 2010 Feb 18. Review.

17.Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.

Armaka M, Apostolaki M, Jacques P, Kontoyiannis DL, Elewaut D, Kollias G.

J Exp Med. 2008 Feb 18;205(2):331-7. doi: 10.1084/jem.20070906. Epub 2008 Feb 4.

18.MUGEN mouse database; animal models of human immunological diseases.

Aidinis V, Chandras C, Manoloukos M, Thanassopoulou A, Kranidioti K, Armaka M, Douni E, Kontoyiannis DL, Zouberakis M, Kollias G; Mugen NoE consortium.

Nucleic Acids Res. 2008 Jan;36(Database issue):D1048-54. Epub 2007 Oct 11.

19.Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis.

Vasilopoulos Y, Gkretsi V, Armaka M, Aidinis V, Kollias G.

Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii23-8. Review.

20.Functional genetic and genomic analysis of modeled arthritis.

Douni E, Armaka M, Kontoyiannis DL, Kollias G.

Adv Exp Med Biol. 2007;602:33-42. Review. No abstract available.

21.Generation and characterization of p38beta (MAPK11) gene-targeted mice.

Beardmore VA, Hinton HJ, Eftychi C, Apostolaki M, Armaka M, Darragh J, McIlrath J, Carr JM, Armit LJ, Clacher C, Malone L, Kollias G, Arthur JS.

Mol Cell Biol. 2005 Dec;25(23):10454-64.

22.Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.

Aidinis V, Carninci P, Armaka M, Witke W, Harokopos V, Pavelka N, Koczan D, Argyropoulos C, Thwin MM, Möller S, Waki K, Gopalakrishnakone P, Ricciardi-Castagnoli P, Thiesen HJ, Hayashizaki Y, Kollias G.

PLoS Genet. 2005 Oct;1(4):e48. Epub 2005 Oct 28. Erratum in: PLoS Genet. 2005 Nov;1(5):e73. Kazunori, Waki [corrected to Waki, Kazunori].

23.Functional analysis of an arthritogenic synovial fibroblast.

Aidinis V, Plows D, Haralambous S, Armaka M, Papadopoulos P, Kanaki MZ, Koczan D, Thiesen HJ, Kollias G.

Arthritis Res Ther. 2003;5(3):R140-57. Epub 2003 Mar 14.

24.Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.

Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G.

J Exp Med. 2002 Dec 16;196(12):1563-74.

25.Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1.

Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M.

Antiviral Res. 1999 Sep;43(2):79-92.

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