The scientists at BSRC “Alexander Fleming” perform cutting-edge research, aiming to understand molecular mechanisms of complex biological processes in health and disease. We are also committed to contribute to innovation in medicine, by developing novel therapeutic and diagnostic methods, focusing on immunity and inflammation, cancer, and neurodegenerative diseases. To keep our focus on top-notch research, we recruit at all levels with excellence as the sole criterion and we support our researchers by providing state-of-the science infrastructures and a pleasant working environment. FLEMING is a non-profit organization operating under the auspices of the Greek General Secretariat for Research & Technology and is supported by the Greek government and by national, European and international grants.
In an invited commentary by Nature Immunology (December 2015 issue), Fleming researcher George Kollias, and John Lambris (UPenn) propose “A ‘rule of 3’ to revive Greek science, research and innovation”. Pubmed
In a new study published in J. Exp. Med., Fleming researchers show that IKKβ deletion in ColVI-expressing intestinal mesenchymal cells protects mice against inflammation-induced intestinal carcinogenesis, revealing a hitherto unknown role of mesenchymal IKKβ in driving inflammation and enabling carcinogenesis in the intestine. Pubmed, commentary.
Fleming Researcher Prof. George Kollias has been awarded the first Galien Scientific Research Award at the Prix Galien Greece 2015. The prize recognizes his seminal contributions towards the development of biological therapies for rheumatoid arthritis and the discovery of novel disease pathways in animal models of chronic inflammation and autoimmunity. (Press release in Greek)
Papanikolopoulou & Skoulakis demonstrate that Tau-mediated neuronal dysfunction and toxicity are separable and in fact neuronal dysfunction, which requires phosphorylation on Ser262, precedes and is required for Ser238 phosphorylation which in turn is requisite for premature lethality. PubMed
Seminar 16/12/2015, 13.00. "Genetics of gene expression regulation in a case-control study for Acute Myocardial Infarction in a Pakistani population", Nikos Panousis, Functional Population Genomics and Genetics of Complex Traits Laboratory University of Geneva Medical School.
Seminar 09/12/2015, 13.00. "Role of parvins in vessel development", Eloi Montanez Miralles, PhD, Walter-Brendel-Center of Experimental Medicine, Ludwig-Maximilians University, Munich, Germany.