29/12/2011. Fleming Researchers (Kontoyiannis Group) revealed the importance of the mRNA regulator HuR, in inflammation supporting tumor development. Using transgenic systems for the deletion or overexpression of HuR in inflammatory cells, they unraveled unprecedented effects in mRNA regulation and demonstrated that enhancing HuR activity may be of clinical benefit in the battle against pathologic inflammation and colitis associated cancer. See [Article; http://www.jci.org/articles/view/45021 ] and related [Commentary; http://www.jci.org/articles/view/61677 ].

13/12/2011. Fleming researcher receives ERC Advanced Grant. Iannis Talianidis (Director of IMBG) was awarded the prestigious ERC Advanced Investigator Grant to study the function of histone modifying enzymes in disease. The award will aid in reinforcing the position of the Institute as a center of excellence in the field of epigenetics.

17/11/2011. Fleming’s researchers have discovered a functional mutation in the mouse Rankl gene that causes Autosomal Recessive Osteopetrosis, a lethal inherited disorder in humans characterized by increased bone mass. Molecular characterization of the causal mutation identified an amino acid critical for RANKL function providing a basis for the design and evaluation of novel RANKL inhibitors that apply in bone-resorptive diseases like osteoporosis. More info

Introducing Biomedcode Hellas SA.
A spin off company of BSRC "Alexander Fleming" providing pre-clinical drug evaluation services to pharmaceutical companies using disease animal models.

The Center has established six core facilities to offer internal and external users direct access to its research infrastructures. The animal house facility, protein chemistry lab, expression profiling facility, transgenic facility, flow cytometry facility, innovation and enterprise unit, genotyping facility and BioIT unit are actively involved in collaborations with both academic and industrial partners.

The BSRC Fleming participates in a number of International programs. Such collaborations are of significant importance for the exchange and dissemination of knowledge and expertise as well as bring together major groups around the world for the study and therapy of human disease.