In a recent study published in PNAS, PhD student Ana Henriques from the labs of Dr. George Kollias and Dr. Vasiliki Koliaraki revealed that the kinase MK2 through the activation of Hsp27 in intestinal mesenchymal cells/CAFs plays an essential role in the promotion of colorectal cancers. [Pubmed].

This work provides insight into the cell specificity of MK2’s function in colorectal cancer, reveals its important role in intestinal mesenchymal cells, provides a novel mechanism of function through the regulation of epithelial proliferation via downstream Hsp27-mediated secretion of protumorigenic mediators and demonstrates the value of MK2 inhibition in the treatment of cancer.

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