Fleming researchers, using a Spondyloarthritis (SpA) mouse model have found that Tnfr2 signaling is regulating polyarthritis and a newly identified heart valve stenosis, which is a common comorbidity of SpA in human patients. [PubMed], [JCI Highlight], [Correspondence].

They have uncovered a dual role for Tnfr2 signaling in these processes, with mesenchymal Tnfr2 driving pathogenesis and non-mesenchymal TNFR2 providing protective signals. The work provides insights into the future use of TNFR2 as a therapeutic target.

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