30/03/2018

Rheumatoid arthritis and Spondyloarthritis are accompanied by several comorbid pathologies in human patients, often involving heart, lung and intestinal pathologies. Using the TNF-driven model of murine arthritis, Fleming researchers recently revealed the co-occurrence of arthritis with valvular heart disease. PubMed , Ann Rheum Dis, Editorial.

Most notably, a common TNF-mediated and mesenchymal-cell driven mechanism was found to be causative of both pathologies. These findings introduce a novel understanding of causative mechanisms in comorbid diseases and lay the ground for future development of therapies commonly targeting such pathogenic pathways. ARD

B.S.R.C. "Alexander Fleming"
34 Fleming Street, 16672 Vari, Greece
Contact us