In a collaborative study published in Nat Med, a Fleming Marie Curie Fellow revealed that aerosolized delivery of active Thyroid Hormone (TH) resolved pulmonary fibrosis in two mouse models through a mechanism that involved improvement of mitochondrial biogenesis and mitophagy in alveolar type II epithelial cells. PubMed.

Similar therapeutic effects were also observed with sobetirome, a well-characterized thyroid-receptor agonist. The results suggest that strategies utilizing lung-targeted TH-therapy should be further studied in patients with fibrotic lung diseases.

Dr. Argyrios Tzouvelekis is a Marie Curie ERS/EU - RESPIRE2 Post-doc Associate at the Biomedical Sciences Research Center Alexander Fleming with Vassilis Aidinis' Research Team.


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