Fleming researchers have revealed that MAP3K8 (TPL2), a Ser/Thr MAP3K kinase, has a central role in the regulation of fibrotic responses in the lung. [PubMed]

In the recently published study [PubMed], TPL2 was found to regulate Cox-2-mediated, prostaglandin E2 production in the lung. The development of pulmonary fibrosis in both humans and mice was shown to entail a transcriptional down regulation of TPL2, leading to the attenuation of PGE2 levels, and its potent anti-fibrotic effects, and the exacerbation of disease severity. 

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