Liakos, Konstantopoulos et al. new study conducted under the supervision of M Lavigne and M Fousteri revealed how maintaining transcription initiation at genes and regulatory regions during genotoxic stress recovery secures the integrity of the whole transcriptome. Performing high throughput genome wide measurements and by developing robust integrative bioinformatics analyses they dissected transcription and chromatin dynamics and showed how human cells respond to significantly limit the potentially carcinogenic effects of DNA damaging stresses present in our daily environment (i.e.: UV irradiation, chemicals or cigarette smoke). 

The study was published in Nature Communications 11, Article number: 916 (2020), 14 February 2020, DOI: 10.1038/s41467-020-14566-9

Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/?term=32060325

B.S.R.C. "Alexander Fleming"
34 Fleming Street, 16672 Vari, Greece
Contact us - Privacy Policy