15/11/2019

Fleming researchers, in collaboration with GlaxoSmithKline and the London School of Hygiene and Tropical Medicine, developed a novel series of fast-kill agents against malaria. Chemoproteomic analysis also showed that the mechanism through which this fast-kill effect is exhibited is the inhibition of serine/arginine protein kinase 2 (SRPK2), thus rendering this target a tractable approach for developing antimalarial compounds with extremely fast-killing properties. [Pubmed]

DOI: 10.1021/acs.jmedchem.9b01099 

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