ࡱ> kj \p ktzovelekiski Ba=  =xx<"8X@"1pArial1pArial1pArial1pArial1pArial1pArial1 pArial1$pArial1pVerdana1pVerdana1pVerdana1pVerdana"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)3#,##0\ " ";\-#,##0\ " "=#,##0\ " ";[Red]\-#,##0\ " "?#,##0.00\ " ";\-#,##0.00\ " "I"#,##0.00\ " ";[Red]\-#,##0.00\ " "q6_-* #,##0\ " "_-;\-* #,##0\ " "_-;_-* "-"\ " "_-;_-@_-k3_-* #,##0\ _ _-;\-* #,##0\ _ _-;_-* "-"\ _ _-;_-@_->_-* #,##0.00\ " "_-;\-* #,##0.00\ " "_-;_-* "-"??\ " "_-;_-@_-{;_-* #,##0.00\ _ _-;\-* #,##0.00\ _ _-;_-* "-"??\ _ _-;_-@_-![$-408]dddd\,\ d\ mmmm\ yyyy"Yes";"Yes";"No""True";"True";"False""On";"On";"Off"],[$ -2]\ #,##0.00_);[Red]\([$ -2]\ #,##0.00\)$[$-409]dddd\,\ mmmm\ dd\,\ yyyy m/d/yy;@ mm/dd/yy;@                           h@ @      0@  0 Q # #   h@ @         8  `I News Aug08T News Sept08i News Oct08-{ News Nov08 News Dec08" \TitleURLDateSourceSummaryGroup Animal ModelsHuman diseasesNLM Animal modelsJResearchers make advances in understanding structure & design of HIV spike PharmaBiz~The use of advanced imaging techniques has allowed researchers to visualize how a key part of the human immunodeficiency virusPhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45519§ionid=20,Scientists develop sensitive salivary sensorPhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45546§ionid=20For people who dislike needles, medical tests that require a drop of saliva instead of a vial of blood will one day make a trip to a doctor or dentist much easierTStudies show targeted drug blocks growth of breast cancer cells that spread to brainUsing laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cellsPhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45572§ionid=20levelopment and characterisation of a novel animal model of prostate inflammation-induced chronic pelvic pain NLM 26/12/2008Chronic pelvic pain due to prostate inflammation is a significant clinical problem. In the current study we developed and validated an animal model of inflammation-induced pelvic pain (NIH category IIIA)http://www.ncbi.nlm.nih.gov/pubmed/19127346?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumpHost-virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptorN LMSignaling lymphocyte activation molecule (SLAM) is thought to be a major cellular receptor for high-host specificity morbilliviruses, which cause devastating and highly infectious diseases in mammals. 21/11/2008http://www.ncbi.nlm.nih.gov/pubmed/19027953?ordinalpos=1711&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\Imaging spontaneous tumorigenesis: Inflammation precedes development of peripheral NK tumors 31/10/2008Early events in tumor development are spontaneous, microscopic, and affected by the microenvironment. We developed a mouse model of spontaneous lymphoma in which malignant transformation is coupled with light emission that can be detected non-invasively using bioluminescent imaging.http://www.ncbi.nlm.nih.gov/pubmed/18971418?ordinalpos=2988&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agentsSeveral hypotheses have been proposed to explain how antiangiogenic drugs enhance the treatment efficacy of cytotoxic chemotherapy, including impairing the ability of chemotherapy-responsive tumors to regrow after therapy. With respect to the latter, we show that certain chemotherapy drugs, e.g., paclitaxel, can rapidly induce proangiogenic bone marrow-derived circulating endothelial progenitor (CEP) mobilization and subsequent tumor homing, whereas others, e.g., gemcitabine, do not.http://www.ncbi.nlm.nih.gov/pubmed/18772115?ordinalpos=4989&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum1The H19 locus acts in vivo as a tumor suppressor.The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated in some human tumors, such as Wilms' tumors. In these cases, biallelic IGF2 expression and lack of expression of H19 are associated with hypermethylation of the imprinting center of this locus. 25/8/2008http://www.ncbi.nlm.nih.gov/pubmed/18719115?ordinalpos=6400&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumStructural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding sitez2F5 is a monoclonal antibody with potent and broadly neutralizing activity against HIV-1. It targets the membrane-proximal external region (MPER) of the gp41 subunit of the envelope glycoprotein and interferes with the process of fusion between viral and host cell membranes. This study presents eight 2F5 F(ab)' crystal structures in complex with various gp41 peptide epitopes.http://www.ncbi.nlm.nih.gov/pubmed/18824005?ordinalpos=984&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumuFc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestineMicrobes and microbial products are closely associated with the pathogenesis of inflammatory bowel disease (IBD); however, the mechanisms behind this connection remain unclear. It has been previously reported that flagellin-specific antibodies are increased in IBD patient sera. As mastocytosis is one of the pathological features of IBD, we hypothesized that flagellin-specific immune responses might activate mast cells that then contribute to the initiation and maintenance of intestinal inflammation. 17/12/2008http://www.ncbi.nlm.nih.gov/pubmed/18974296?ordinalpos=481&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumSCharacterization of cytokine production by human term placenta macrophages in vitroPROBLEM: Macrophages are apparently the only immune cells within placenta villi, yet functions of these cells remain obscure. It has been postulated that placental macrophages accomplish regulatory roles at the fetal-maternal interface by means of wide variety of secreted cytokines. We attempt to analyze the patterns of cytokine production in an isolated population of placental macrophages.http://www.ncbi.nlm.nih.gov/pubmed/18853988?ordinalpos=483&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumXUse of a leucocyte filter to remove tumour cells from intra-operative cell salvage bloodSUMMARY: The intra-operative blood loss of 50 consecutive gynae-oncology patients undergoing surgery for endometrial, cervical or ovarian cancer was cell salvaged and filtered. In each case blood samples were taken from the effluent tumour vein, a central venous line, the cell saver reservoir, the cell salvage re-transfusion bag after processing but before filtration and from the cell salvage re-transfusion bag after processing and filtration.http://www.ncbi.nlm.nih.gov/pubmed/19032302?ordinalpos=489&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumType 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells!Melanoma patients may exhibit a T(H)2-skewed cytokine profile within blood and tumor-infiltrating lymphocytes. Therapies that induce beneficial T(H)1-type tumor-specific immune responses, therefore, are highly desirable. Dendritic cells (DC) are widely used as immune adjuvants for cancer.http://www.ncbi.nlm.nih.gov/pubmed/19010919?ordinalpos=1082&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum 15/11/2008gLeptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8We have shown that ObRb, the leptin receptor, is overexpressed in colorectal cancer cells, and that this may influence the patients' outcome. We investigated colonocytes as leptin targets and characterized their pivotal role in antitumor immune response. Cytokine and chemokine mRNAs in HT29 cells were measured by targeted arrays. In vitro, normal colonocytes and human colon cancer cells (HT29, Caco-2, SW480, and HCT116) were used to investigate ObRb transduction system and cytokine releases.http://www.ncbi.nlm.nih.gov/pubmed/19010917?ordinalpos=1084&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDoc<SumMonoclonal antibody CC188 binds a carbohydrate epitope expressed on the surface of both colorectal cancer stem cells and their differentiated progenyPURPOSE: Recently, cancer stem cells (CSC), undifferentiated cancer progenitor cells, have been successfully isolated from colorectal tumors. Targeting both CSCs and differentiated, rapidly proliferating tumor cells with therapeutic drugs provides a focused strategy to treat cancer. In this study, we isolated the monoclonal antibody (mAb) CC188 and characterized the epitope recognized by mAb CC188, which is useful for developing biological reagents that target CSCs.http://www.ncbi.nlm.nih.gov/pubmed/19010863?ordinalpos=1089&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumHTumor infection by oncolytic reovirus primes adaptive antitumor immunityPURPOSE: Early clinical trials are under way exploring the direct oncolytic potential of reovirus. This study addresses whether tumor infection by reovirus is also able to generate bystander, adaptive antitumor immunity. EXPERIMENTAL DESIGN: Reovirus was delivered intravenously to C57BL/6 mice bearing lymph node metastases from the murine melanoma, B16-tk, with assessment of nodal metastatic clearance, priming of antitumor immunity against the tumor-associated antigen tyrosinase-related protein-2, and cytokine responses.http://www.ncbi.nlm.nih.gov/pubmed/19010851?ordinalpos=1092&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumExpansion of human cytomegalovirus (HCMV) immediate-early 1-specific CD8+ T cells and control of HCMV replication after allogeneic stem cell transplantationhttp://www.ncbi.nlm.nih.gov/pubmed/18684826?ordinalpos=1087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumPRecovery of human cytomegalovirus (HCMV)-specific T immunity is critical for protection against HCMV disease in the early phase after allogeneic stem cell transplantation (SCT). Using an enzyme-linked immunospot assay with overlapping 15-mer peptides spanning pp65 and immediate-early 1 HCMV proteins, we investigated which HCMV-specific CD8(+) gamma interferon-positive (IFN-gamma(+)) T-cell responses against pp65 and IE-1 were associated with control of HCMV replication in 48 recipients of unmanipulated HLA-matched allografts at 3 months (M3) and 6 months (M6) after SCT and in 23 donors6Hematogones in acute leukemia during and after therapyoAfter each leukemia therapy phase, characteristics of normal regenerating B-cells may be reminiscent of and mistaken for a relapse. We compared the incidence and phenotypic characteristics of hematogone stages in a total of 669 bone marrow aspirates from 107 patients with B-ALL, 97 patients of AML, and 27 patients with T-ALL at diagnosis, during, and after therapy.http://www.ncbi.nlm.nih.gov/pubmed/18452085?ordinalpos=1095&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum;Cancer/testis genes expression in human melanoma cell linesZWe analyzed the expression of 15 cancer/testis and four melanoma differentiation antigens in 21 metastatic melanoma cell lines using reverse transcriptase-polymerase chain reaction (RT-PCR) assay. On the basis of morphological characteristics, tumor cell lines were divided into three groups with high, moderate, and low grade of differentiation.http://www.ncbi.nlm.nih.gov/pubmed/18781128?ordinalpos=1102&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumUse of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patientsIt is a challenging task to verify and quantify potential biomarkers expressed at elevated levels in sera from cancer patients. An immunoaffinity-mass spectrometry-based approach has been developed using antibodies to enrich proteins of interest from sera followed by mass spectrometry-based quantification. Antibodies specific to the protein of interest were immobilized to hydrazide resin via the carbohydrate moiety on the Fc region of the antibody.http://www.ncbi.nlm.nih.gov/pubmed/18388126?ordinalpos=1107&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumdRecognizing calcific uremic arteriolopathy in autoimmune disease: an emerging mimicker of vasculitisCalcinosis has long been associated with autoimmune disease and has a distinctive profile in scleroderma, dermatomyositis, systemic lupus erythematosus, and overlap syndromes. However, there have also been a number of case studies of calcific uremic arteriolopathy, or calciphylaxis, described within vessels, including patients with chronic renal insufficiency and several forms of vasculitis.http://www.ncbi.nlm.nih.gov/pubmed/18774119?ordinalpos=1087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumPDIA3, HSPA5 and vimentin, proteins identified by 2-DE in the valvular tissue, are the target antigens of peripheral and heart infiltrating T cells from chronic rheumatic heart disease patientsRheumatic fever (RF) is a post-infectious autoimmune disease due to sequel of group A streptococcus (GAS) pharyngitis. Rheumatic heart disease (RHD), the major manifestation of RF, is characterized by inflammation of heart valves and myocardium. Molecular mimicry between GAS antigens and host proteins has been shown at B and T cell level. However the identification of the autoantigens recognized by B and T cells within the inflammatory microenvironment of heart tissue in patients with RHD is still incompletely elucidated.http://www.ncbi.nlm.nih.gov/pubmed/18541406?ordinalpos=1681&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumuPrevalence and significance of antibodies to citrullinated human papilloma virus-47 E2345-362 in rheumatoid arthritisIt has been confirmed that antibodies to citrullinated profilaggrin306-324 may play important roles in RA. In this study, human papilloma virus (HPV)-47 E2345-362, homologous to profilaggrin306-324, was found using the NCBI BLAST program. Then, E2345-362 and citrullinated E2345-362, with arginine348 replaced by citrulline, were synthesized. The presence of antibodies against these peptides was examined by an enzyme-linked immunosorbent assay.http://www.ncbi.nlm.nih.gov/pubmed/18511237?ordinalpos=1682&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumAntiretroviral therapy-induced functional modification of IgG4 and IgM responses in HIV-1-infected individuals screened by an allosteric biosensorWe have explored the effect of antiretroviral drugs on the antiviral immune response in human immunodeficiency virus-1 (HIV-1)-infected patients by using an enzymatic immunosensor that detects epitope-modifying anti-gp41 antibodies. By this molecular sensing approach, we have identified an irreversible impact of drug administration on the functionality of IgG4 and IgM specific antibodies regarding the structural modification promoted on their target epitope.http://www.ncbi.nlm.nih.gov/pubmed/18708531?ordinalpos=1683&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumb: ]P"xq5*!'[.y/6 t="Eccc  J^M  dMbP?_*+%"??U} $} I } } } } $        &  ( ' )    ~ C@      ~ V@    ~ V@   "NxTTTTF>@  $ 7|yK Qhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45519&sectionid=20yK http://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45519&sectionid=20|yK Qhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45546&sectionid=20yK http://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45546&sectionid=20|yK Qhttp://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45572&sectionid=20yK http://www.pharmabiz.com/article/detnews.asp?Arch=a&articleid=45572&sectionid=20yK http://www.ncbi.nlm.nih.gov/pubmed/18719115?ordinalpos=6400&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18719115?ordinalpos=6400&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum  X[  dMbP?_*+%MAuto HP LaserJet 4050 Series P4C odLetter DINU"4~q" d??U} $ }  }  } m }  } I( } $          #  ~ !b@  $ % "  P  ~ !D@  Q R "  S  ~ !D@  T U "  V  ~ !D@  W X "  Y  ~ !D@  Z ["!xTTTTTT>@  7yK http://www.ncbi.nlm.nih.gov/pubmed/18772115?ordinalpos=4989&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18772115?ordinalpos=4989&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK http://www.ncbi.nlm.nih.gov/pubmed/18774119?ordinalpos=1087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18774119?ordinalpos=1087&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK http://www.ncbi.nlm.nih.gov/pubmed/18541406?ordinalpos=1681&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18541406?ordinalpos=1681&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK http://www.ncbi.nlm.nih.gov/pubmed/18511237?ordinalpos=1682&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18511237?ordinalpos=1682&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK http://www.ncbi.nlm.nih.gov/pubmed/18708531?ordinalpos=1683&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSumyK :http://www.ncbi.nlm.nih.gov/pubmed/18708531?ordinalpos=1683&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum  Vjpm  dMbP?_*+%"F??U} F} mF} F} F} F} $F@            !  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