It can be argued that the large capacity to learn, remember and use the acquired information in novel ways is the defining characteristic of our species. The long-term goal of the research program in our laboratory is to understand the molecular mechanisms and signaling systems that mediate learning and memory and how these are altered by aging, disease and adverse environmental factors. The essential nature of these processes is well documented by debilitating human conditions that disrupt them, such as learning disabilities, Alzheimer's, and the various amnesias. Progress towards amelioration and eventual cure of such pathological situations requires understanding the molecular signaling mechanisms that normally govern learning and memory and their relationship to signaling cascades utilized for other vital processes.