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George Mosialos' research group

Publications

 

2006

Tzimas C, Michailidou G, Arsenakis M, Kieff E, Mosialos G. , Hatzivassiliou EG., 2006, "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB." , Cell Signal., 2006 Jan, 18(1):83-92 [PubMed].

2005

Wang L, Baiocchi RA, Pal S, Mosialos G. ,Caligiuri M, Sif S., 2005, "The BRG1- and hBRM-associated factor BAF57 induces apoptosis by stimulating expression of the cylindromatosis tumor suppressor gene." , Mol Cell Biol., 2005 Sep, 25(18):7953-65 [PubMed].

Hatzivassiliou EG, Tsichritzis T, Mosialos G. , 2005, "Induction of apoptosis by rewiring the signal transduction of Epstein-Barr virus oncoprotein LMP1 toward caspase activation." , J Virol., 2005 Apr, 79(8):5215-9 [PubMed].

2004

Panagopoulos D., Victoratos P., Alexiou M., Kollias G., Mosialos G., 2004, "Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo", J. Virol., 78, 13253-13261 [PubMed].

Jono H., Lim J. H., Chen L. F., Xu H., Trompouki E., Pan Z. K., Mosialos G., Li J. D., 2004, "NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB: Evidence for A Novel Inducible Auto-Regulatory Feedback Pathway", J. Biol. Chem., 279, 36171-36174 [PubMed].

2003

Luftig M., Prinarakis E., Yasui T., Tsichritzis T., Cahir-McFarland E., Inoue J. I., Nakano H., Mak T. W., Yeh W. C., Li X., Akira S., Suzuki N., Suzuki S., Mosialos G., Kieff E., 2003, "Epstein-Barr Virus Latent Membrane Protein 1 Activation of NF-κB Through IRAK1 and TRAF6", Proc. Natl. Acad. Sci. U.S.A., 100, 15595-15600 [PubMed].

Trompouki E., Hatzivassiliou E., Tsichritzis T., Farmer H., Ashworth A., Mosialos G., 2003, "CYLD is a deubiquitinating enzyme that negatively regulates NF-kB activation by TNFR family members", Nature, 424, 793-796 [PubMed].

2002

Prokova V., Mosialos G., Kardassis D., 2002, "Inhibition of transforming growth factor beta signaling and Smad-dependent activation of transcription by the latent membrane protein 1 of Epstein-Barr virus", J. Biol. Chem., 277, 9342-9350 [PubMed].

Hatzivassiliou E., Mosialos G., 2002, "Cellular signalling pathways engaged by the Epstein-Barr virus transforming protein LMP1", Frontiers in Bioscience, 7, 319-329 [PubMed].

2001

Mosialos G., 2001, "Cytokine signaling and Epstein-Barr virus-mediated cell transformation", Cytokine Growth Factor Rev., 12, 259-270 [PubMed].

Ishii T., Kwon H., Hiscott J., Mosialos G., Koromilas A. E., 2001, "Activation of the IkappaBalpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR", Oncogene, 20, 1900-1912 [PubMed].

Luftig M. A., Cahir-McFarland E., Mosialos G., Kieff E. D., 2001, "Effects of the NIK aly mutation on NF-{kappa}B activation by the Epstein-Barr virus latent infection membrane protein, LT{beta}R, and CD40", J. Biol. Chem., 276, 14602-14606 [PubMed].

2000

Sylla B. S., Murphy K., Cahir-McFarland E., Lane W. S., Mosialos G., Kieff E., 2000, "The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B", Proc. Natl. Acad. Sci. U.S.A., 97, 7470-7475 [PubMed].

1999

Cahir McFarland E. D., Izumi K. M., Mosialos G., 1999, "Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB", Oncogene, 18, 6959-6964 [PubMed].

1998

Devergne O., McFarland E. C., Mosialos G., Izumi K. M., Ware C. F., Kieff E., 1998, "Role of the the TRAF binding site and NF-kB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression", J. Virol., 72, 7900-7908 [PubMed].

Sylla B. S., Hung S. C., Davidson D., Hatzivassiliou E., Malinin N., Wallach D., Gilmore T. D., Kieff E., Mosialos G., 1998, "Epstein-Barr virus transforming protein latent infection membrane protein 1 activates transcription factor NF-kB through a pathway that includes the NF-kB-inducing kinase and the IkB kinases IKKa and IKKb", Proc. Natl. Acad. Sci. U.S.A., 95, 10106-10111 [PubMed].

Hatzivassiliou E., Miller W., Raab-Traub N., Kieff E., Mosialos G., 1998, "A fusion of the Epstein-Barr virus latent membrane protein 1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor kB, and stress activated protein kinase", J. Immunol., 160, 1116-1121 [PubMed].

1997

Mosialos G., 1997, "The role of Rel/NF-kB proteins in viral oncogenesis and the regulation of viral transcription", Seminars in Cancer Biology, 8, 121-129 [PubMed].

Chatila T., Ho N., Liu P., Liu S., Mosialos G., Kieff E., Speck S., 1997, "The Epstein-Barr Virus induced Ca<sup>2+</sup>/Calmodulin dependent kinase type IV/GR promotes a Ca<sup>+2</sup> dependent switch from latency to viral replication", J. Virol., 71, 6560-6567 [PubMed].

VanArsdale T., VanArsdale S., Force W., Walter B., Mosialos G., Kieff E., Reed J., Ware C., 1997, "Lymphotoxin-beta Receptor signaling complex: the role of TRAF3 recruitment in cell death and activation of Nuclear Factor-κB", Proc. Natl. Acad. Sci. U.S.A., 94, 2460-2465 [PubMed].

Pinkus G. S., Pinkus J. I., Langhoff E., Matsumura F., Yamashiro S., Mosialos G., Said J. W., 1997, "Fascin, a sensitive new marker for Reed-Sternberg cells of Hodgkin's Disease. Evidence for a dendritic or B cell derivation?", Am. J. Pathol., 150, 543-562 [PubMed].

Miller W., Mosialos G., Kieff E., Raab-Traub N., 1997, "Epstein-Barr Virus LMP1 induction of the Epidermal Growth Factor Receptor is mediated through a TRAF signaling pathway distinct from NF-κB", J. Virol., 71, 586-594 [PubMed].

Mosialos G., 1997, "Signal transduction by the Epstein-Barr virus latent membrane protein-1", EBV Report, 4, 121-126.

1996

Eliopoulos A., Dawson C., Mosialos G., Floettmann J., Rowe M., Armitage R., Dawson J., Kerr D., Wakelman M., Reed J., Kieff E., Young L., 1996, "CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: Involvement of TRAF3 as a common mediator", Oncogene, 13, 2243-2254 [PubMed].

Devergne O., Hatzivasilliou E., Izumi K., Kaye K., Kleijnen M., Kieff E., Mosialos G., 1996, "Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation", Mol. Cell. Biol., 16, 7098-7108 [PubMed].

Ishida T., Mizushima S., Azuma S., Kobayshi N., Tojo T., Suzuki K., Aizawa S., Watanabe T., Mosialos G., Kieff E., Yamamoto T., Inoue J., 1996, "Identification of TRAF6, a novel TRAF protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region", J. Biol. Chem., 271, 28745-28748 [PubMed].

Kaye K., Devergne O., Harada J., Izumi K., Yalamanchili R., Kieff E., Mosialos G., 1996, "TNF Receptor Associated Factor 2 (TRAF2) is a mediator of NF-κB Activation by the Epstein-Barr Virus Transforming Protein LMP1", Proc. Natl. Acad. Sci. U.S.A., 93, 11085-11090 [PubMed].

Mosialos G., Birkenbach M., Ayehunie S., Kieff E., Langhoff E., 1996, "Circulating dendritic cells differentially express high levels of a 55-kD actin bundling protein", Am. J. Pathol., 148, 593-599 [PubMed].

1995

Johannsen E., Koh E., Mosialos G., Tong X., Kieff. E, Grossman E., 1995, "Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by Jk and PU.1", J. Virol., 69, 253-262 [PubMed].

Mosialos G., Birkenbach M., Yalamanchili R., VanArsdale T., Ware C., Kieff E., 1995, "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family", Cell, 80, 389-399 [PubMed].

Kaye K., Izumi K., Mosialos G., Kieff E., 1995, "The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B lymphocyte transformation; fibroblast co-cultivation complements a critical function within the terminal 155 residues", J. Virol., 69, 675-683 [PubMed].

Tong X., Drapkin R., Yalamanchili R., Mosialos G., Kieff E., 1995, "The Epstein-Barr virus nuclear protein 2 acidic domain interacts with a novel cellular coactivator that can associate with TFIIE", Mol. Cell. Biol., 15, 4735-4744 [PubMed].

1994

Feinstein R., Bolton W. K., Quinones J. N., Mosialos G., Sif S., Huff J. L., Capobianco A. J., Gilmore T. D., 1994, "Characterization of a chicken cDNA encoding the retinoblastoma gene product", Biochim. Biophys. Acta, 1218, 82-86 [PubMed].

Mosialos G., Hanissian S., Jawahar S., Vara L., Kieff E., Chatalia T., 1994, "A Ca++/Calmodulin-dependent protein kinase-Gr, expressed after transformation of primary B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1", J. Virol., 68, 1697-1705 [PubMed].

Yalamanchili R., Tong X., Grossman S., Johannsen E., Mosialos G., Kieff E., 1994, "Genetic and biochemical evidence that EBNA 2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV", Virology, 204, 634-641 [PubMed].

Mosialos G., Yamashiro S., Baughman R., Matsudaira P., Vara L., Matsumura F., Kieff E., Birkenbach M., 1994, "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kD actin-bundling protein", J. Virol., 68, 7320-7328 [PubMed].

1993

Mosialos G., Gilmore T. D., 1993, "vRel and cRel are differentially affected by mutations at a conserved protein kinase recognition sequence", Oncogene, 8, 721-730 [PubMed].

1992

Capobianco A. J., Chang D., Mosialos G., Gilmore T. D., 1992, "p105, the NF-κB p50 precursor, is one of the cellular proteins complexed with the vRel oncoprotein in transformed chicken spleen cells", J. Virol., 66, 3758-3767 [PubMed].

1991

Mosialos G., Hamer P., Capobianco A. J., Laursen R. A., Gilmore T. D., 1991, "A conserved protein kinase-A recognition sequence is structurally linked to transformation by p59<sup>v-rel</sup> and cytoplasmic retention of p68<sup>c-rel</sup>", Mol. Cell. Biol., 11, 5867-5877 [PubMed].

1990

Delwart E. L., Mosialos G., Gilmore T. D., 1990, "Retroviral envelope glycoproteins contain Leucine Zipper:-like repeat", AIDS Research and Human Retroviruses, 6, 703-706 [PubMed].

Kamens J., Richardson P., Mosialos G., Brent R., Gilmore T. D., 1990, "Oncogenic transformation by vRel requires an amino-terminal activation domain", Mol. Cell. Biol., 10, 2840-2847 [PubMed].

1989

Yupsanis T., Mosialos G., Georgatsos J. G., 1989, "Redundancy of a chromatin-associated nuclease in a wheat-rye hybrid", Biochimie und Physiologie der Pflanzen, 184, 179-182.