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Pantelis Hatzis' research group

Publications

1. Mokry M, Hatzis P, de Bruijn E, Guryev V, Koster J, Versteeg R, Schuijers J, van de Wetering M, Clevers H, Cuppen E. Double fragmentation ChIP-seq provides single nucleotide resolution of Tcf4 binding characteristics. PLoSOne. In press

2. Mahmoudi T, Boj SF, Hatzis P, Li, VSW, Taouatas N, Vries RGJ, Teunissen H, Begthel, H, Korving, J, Mohammed S, Heck AJR, Clevers H. The Leukemia-Associated MLLT10 and DOT1L proteins are critical activators of Wnt target genes. PLoSBiology. In press

3. Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Freed E, Brown MA, Lynch JP, Dang DT, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-elements in intestinal cells. PNAS. 107(34): 15157-62

4. Ng SS, Mahmoudi T, Li VS, Hatzis P, Boersema PJ, Mohammed S, Heck AJ, Clevers H. (2010) MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biol Chem. 391(2-3): 171-80

5. van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. (2009) Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 136(5): 903-12

6. Armand AS, Bourajjaj M, Martínez-Martínez S, el Azzouzi H, da Costa Martins PA, Hatzis P, Seidler T, Redondo JM, De Windt LJ. (2008) Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem. 283(43):29004-10.

7. Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg HG. (2008) Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 28(8): 2732-44

8. Hatzis P, Kyrmizi I, Talianidis I. (2006) Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression. Mol Cell Biol. 26(19):7017-29

9. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I. (2006)Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 20(16): 2293-305

10. van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol. 7(4): 381-6

11. Hatzis P, Talianidis I. (2002) Dynamics of enhancer-promoter communication during differentiation-induced gene activation. Mol Cell. 10(6): 1467-77

12. Hatzis P, Talianidis I. (2001) Regulatory mechanisms controlling human hepatocyte nuclear factor 4alpha gene expression. Mol Cell Biol. 21(21): 7320-30.

13. Conlan RS, Gounalaki N, Hatzis P, Tzamarias D. (1999) The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co- activator. J Biol Chem. 274(1): 205-10

14. Hatzis P, Al-Madhoon AS, Jüllig M, Petrakis TG, Eriksson S, Talianidis I. (1998) The intracellular localization of deoxycytidine kinase. J Biol Chem. 273(46): 30239-43