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Eleni Douni's research group
Publications
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium , de Angelis MH, Brown SD, Hancock JM, Mallon AM.,
2010,
"EuroPhenome: a repository for high-throughput mouse phenotyping data.",
Nucleic Acids Res,
2010 Jan;38(Database issue):,
D577-85. Epub 2009 Nov 23.;
[PubMed].
Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P.
2009,
"Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.",
Arthritis Res Ther.,
2009 Sep 18;11(5):R138. [Epub ahead of print] ,
[PubMed]
Douni E.,
Armaka M., and Kollias G. (2007).
Functional genetic and genomic analysis of modeled arthritis.
Advances in Experimental Medicine and Biology.
Springer, in
press.
Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A,
Douni E.,
Blackshear PJ, Kontoyiannis DL, Kollias G.
(2006).
Transmembrane TNF protects mutant mice against intracellular
bacterial infections, chronic inflammation and autoimmunity.
European Journal of Immunology,
Oct;36(10):2768-80.
Douni, E.,
Sfikakis, P., Haralambous, S., Fernandez, P. and Kollias G. (2004).
Attenuation
of inflammatory polyarthritis in TNF transgenic mice by diacerein:
comparative analysis with dexamethasone, methotrexate and anti-TNF
protocols. Arthritis Research & Therapy, 6(1):R65-R72.
Douni E.,
Alexiou M., Kontoyiannis D., and Kollias G. (2004). Genetic
engineering in the mouse: Tuning TNF/TNFR expression. In Methods in
Molecular Medicine, Vol. 98: Tumor Necrosis Factor. Eds A. Corti and
P. Ghezzi. Humana Press Inc., p139-171.
Maung-Maung, T., Douni, E., Aidinis V., Kollias, G.,
Kodama, K., Sato, K., Satish, R.L., Mahendran, R., and
Gopalakrishnakone, P. (2004).
Effect of Phospholipase A2 Inhibitory Peptide on Inflammatory
Arthritis in a TNF Transgenic Mouse Model: A Time Course
Ultrastructural Study. Arthritis Research & Therapy,
6(3):R282-94.
Akassoglou,
Κ.,
Douni,
Ε.,
Bauer, J., Lassmann, H., Kollias, G. and Probert, L. (2003).
The
p75TNF Receptor Independently Signals Pro-inflammatory Effects of
TNF at the CNS Vasculature and the Development of Spontaneous
Inflammatory Ischaemia in Transgenic Mice. PNAS,
100:709-714
.
Holtmann, M., Douni, E., Schutz, M., Mudter, J., Lehr,
H., Gerspach, J., Scheurich, P., Galle, P., Kollias, G. and Neurath,
M. (2002).
TNF-R2 is upregulated on lamina propria mononuclear cells in Crohn`s
disease and promotes experimental colitis in vivo. European
Journal of Immunology, 32:3142-3151.
Kollias, G., Kontoyiannis, D., Douni, E, and Kassiotis
G. (2002).
The
role of TNF/TNFR in organ-specific and systemic autoimmunity:
implications for the design of optimized `anti-TNF` therapies.
Curr. Dir. Autoimmun.; 5:30-50.
Kollias, G., Douni, E., Kassiotis, G., and
Kontoyiannis, D. (1999). The function of tumour necrosis
factor and receptors in models of multi-organ inflammation,
rheumatoid arthritis, multiple sclerosis and inflammatory bowel
disease. Ann. Rheum. Dis., 58, 132-139.
Kollias, G., Douni, E., Kassiotis, G., and
Kontoyiannis, D. (1999).
On
the role of tumor necrosis factor and receptors in models of
multiorgan failure, rheumatoid arthritis, multiple sclerosis and
inflammatory bowel disease. Immunological Reviews, 169,
175-194.
Douni, E.,
and Kollias, G. (1998).
A critical role of the p75TNF-R
in organ inflammation independent of TNF, LTα
or the p55 TNF-R. Journal of Experimental Medicine, 188,
1343-1352.
Kusters, S., Tiegs, G., Alexopoulou, L., Pasparakis, M.,
Douni, E., Kunstle, G., Bluethmann, H., Wendel, A.,
Pfizenmaier, K., Kollias, G., and Grell, M. (1997).
In vivo
evidence for a functional role of both tumor necrosis factor (TNF)
receptors and transmembrane TNF in experimental hepatitis.
European Journal of Immunology, 27, 2870-2875.
Douni, E.,
Akassoglou, K., Alexopoulou, L., Georgopoulos, S., Haralambous, S.,
Hill, S., Kassiotis, G., Kontoyiannis, D., Pasparakis, M., Plows,
D., Probert, L., and Kollias, G. (1996). Transgenic and
knockout analysis of the role of TNF in immune regulation and
disease pathogenesis. Journal of Inflammation, 47, 27-38.
Pasparakis, M., Alexopoulou, L., Douni, E., and
Kollias, G. (1996).
Tumour
necrosis factors in immune regulation: everything that’s interesting
is … new! Cytokine and Growth Factor Reviews, 7, 223-229.
Probert,
L., Akassoglou, K., Alexopoulou, L., Douni, E.,
Haralambous, S., Hill, S., Kassiotis, G., Kontoyiannis, D.,
Pasparakis, M., Plows, D., and Kollias, G. (1996). Dissection
of the pathologies induced by transmembrane and wild-type tumour
necrosis factor in transgenic mice. Journal of Leukocyte Biology,
59, 518-525.
Grell,
M., Douni, E., Wajant, H., Lohden, M., Clauss, M.,
Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G.,
Pfizenmaier, K., Scheurich, P. (1995).
The
transmembrne form of tumour necrosis factor (TNF) is the prime
activating ligand of the 80 kDa TNF receptor. Cell, 83,
793-802.
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