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Eleni Douni's research group

Publications

Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium , de Angelis MH, Brown SD, Hancock JM, Mallon AM., 2010, "EuroPhenome: a repository for high-throughput mouse phenotyping data.", Nucleic Acids Res, 2010 Jan;38(Database issue):, D577-85. Epub 2009 Nov 23.; [PubMed].

Thwin MM, Douni E, Arjunan P, Kollias G, Kumar PV, Gopalakrishnakone P. 2009, "Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.", Arthritis Res Ther., 2009 Sep 18;11(5):R138. [Epub ahead of print] , [PubMed]

Douni E., Armaka M., and Kollias G. (2007). Functional genetic and genomic analysis of modeled arthritis. Advances in Experimental Medicine and Biology. Springer, in press.

Alexopoulou L, Kranidioti K, Xanthoulea S, Denis M, Kotanidou A, Douni E., Blackshear PJ, Kontoyiannis DL, Kollias G. (2006). Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. European Journal of  Immunology, Oct;36(10):2768-80.

Douni, E., Sfikakis, P., Haralambous, S., Fernandez, P. and Kollias G. (2004). Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols. Arthritis Research & Therapy,  6(1):R65-R72.

Douni E., Alexiou M., Kontoyiannis D., and Kollias G. (2004). Genetic engineering in the mouse: Tuning TNF/TNFR expression. In Methods in Molecular Medicine, Vol. 98: Tumor Necrosis Factor. Eds A. Corti and P. Ghezzi. Humana Press Inc., p139-171.

Maung-Maung, T., Douni, E., Aidinis V., Kollias, G., Kodama, K., Sato, K., Satish, R.L., Mahendran, R., and Gopalakrishnakone, P. (2004). Effect of Phospholipase A2 Inhibitory Peptide on Inflammatory Arthritis in a TNF Transgenic Mouse Model: A Time Course Ultrastructural Study. Arthritis Research & Therapy, 6(3):R282-94.

Akassoglou, Κ., Douni, Ε., Bauer, J., Lassmann, H., Kollias, G. and Probert, L. (2003). The p75TNF Receptor Independently Signals Pro-inflammatory Effects of TNF at the CNS Vasculature and the Development of Spontaneous Inflammatory Ischaemia in Transgenic Mice. PNAS, 100:709-714 .

Holtmann, M., Douni, E., Schutz, M., Mudter, J., Lehr, H., Gerspach, J., Scheurich, P., Galle, P., Kollias, G. and Neurath, M. (2002). TNF-R2 is upregulated on lamina propria mononuclear cells in Crohn`s disease and promotes experimental colitis in vivo. European Journal of Immunology, 32:3142-3151.

Kollias, G., Kontoyiannis, D., Douni, E, and Kassiotis G. (2002). The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized `anti-TNF` therapies. Curr. Dir. Autoimmun.; 5:30-50.

Kollias, G., Douni, E., Kassiotis, G., and Kontoyiannis, D. (1999). The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Ann. Rheum.  Dis., 58, 132-139.

Kollias, G., Douni, E., Kassiotis, G., and Kontoyiannis, D. (1999). On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunological Reviews, 169, 175-194.

Douni, E., and Kollias, G. (1998). A critical role of the p75TNF-R in organ inflammation independent of TNF, LTα or the p55 TNF-R. Journal of Experimental Medicine, 188, 1343-1352.

Kusters, S., Tiegs, G., Alexopoulou, L., Pasparakis, M., Douni, E., Kunstle, G., Bluethmann, H., Wendel, A., Pfizenmaier, K., Kollias, G., and Grell, M. (1997). In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. European Journal of Immunology, 27, 2870-2875.

Douni, E., Akassoglou, K., Alexopoulou, L., Georgopoulos, S., Haralambous, S., Hill, S., Kassiotis, G., Kontoyiannis, D., Pasparakis, M., Plows, D., Probert, L., and Kollias, G. (1996). Transgenic and knockout analysis of the role of TNF in immune regulation and disease pathogenesis. Journal of Inflammation, 47, 27-38.

Pasparakis, M., Alexopoulou, L., Douni, E., and Kollias, G. (1996). Tumour necrosis factors in immune regulation: everything that’s interesting is … new! Cytokine and Growth Factor Reviews, 7, 223-229.

Probert, L., Akassoglou, K., Alexopoulou, L., Douni, E., Haralambous, S., Hill, S., Kassiotis, G., Kontoyiannis, D., Pasparakis, M., Plows, D., and Kollias, G. (1996). Dissection of the pathologies induced by transmembrane and wild-type tumour necrosis factor in transgenic mice. Journal of Leukocyte Biology, 59, 518-525.

Grell, M., Douni, E., Wajant, H., Lohden, M., Clauss, M., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G., Pfizenmaier, K., Scheurich, P. (1995). The transmembrne form of tumour necrosis factor (TNF) is the prime activating ligand of the 80 kDa TNF receptor. Cell, 83, 793-802.