The Biomedical Sciences Research Center "Alexander
Fleming" is a governmental,
non-profit institution with a history closely linked to the Greek
Foundation for Basic Biological Research "Alexander Fleming".
The Center started its research functions in 1998 and is today actively
involved in research areas covering immunology, molecular biology
and genetics and molecular oncology.
BSRC Fleming has staffed its laboratories with leading researchers and has achieved international acclaim for its cutting-edge research in disease modeling via transgenesis, cellular immunology, transcriptional and post-transcriptional regulation of gene expression, inter- and intracellular signaling, functional genomics and stem cell biology.
Competitive funding from National Sources, the European Commission, US organizations and international or local industry, amount each year for 70-80% of the total budget of the Center. This strong position in competitive funding, relative to the number of senior researchers, is the result of the center's strategic prioritization of research, which fall tightly within European academic and industrial biomedical research priorities.
To date, the Center has developed three out of its five research Institutes:
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Highlights
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Researchers of BSRC Al. Fleming contribute to a EU consortium in order to propose strategies for balancing the pathogenic/beneficial effects of TNF in opportunistic infections appearing in anti-TNF treated patients. More info |
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Researchers at the Institute for Immunology, utilizing comparative expression profiling, have discovered new genes and pathways involved in the pathophysiology of pulmonary fibrosis. Among them and through the utilization of tissue microarrays, HIF-1a was shown to have an early primary role in disease pathogenesis. [Pubmed] | ||
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Al. Fleming researchers participate in consortium to collate mouse genetics. see related press release | read about the database revolution |
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The MUGEN Mouse Database (MMdb) is a database of murine models of immune processes and immunological diseases. It was developed in the context of MUGEN network of Excellence (MUGEN NoE) and serves as a use-case example of database integration and interoperability, in the context of CASIMIR, a co-ordination action on mouse resource integration. An article describing MMdb has recently been published in the Nucleic Acid Research Database Issue [Pubmed]. | ||
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BSRC Fleming's TgDb provides on-line information on mouse strains expressing recombinases for the temporal and spatial genetic recombination of conditionally mutagenised genes. It is the largest European virtual repository of its kind, and was designed to be complementary to a number of European projects aiming to manipulate the mouse genome (EUCOMM, EUMODIC, MUGEN) in order to reveal the complexity of gene function and to design better models of human diseases. TgDb is still actively developed and curated. | ||
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Introducing
Biomedcode Hellas SA. A spin off company of BSRC "Alexander Fleming" providing pre-clinical drug evaluation services to pharmaceutical companies using disease animal models. |
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Fleming is offering several education and job opportunities. For more information look at our job openings page. | ||
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The Center has established two core facilities to offer internal and external users direct access to its research infrastructures. The mouse facility and protein chemistry facilities are actively involved in collaborations with both academic and industrial partners. | ||
