Ερευνητική ομάδα Γεωργίου Κόλλια

Δημοσιεύσεις

2004

Panagopoulos D., Victoratos P., Alexiou M., Kollias G., Mosialos G., 2004, "Comparative analysis of signal transduction by CD40 and the Epstein-Barr Virus Oncoprotein LMP1 in vivo", J. Virol., 78 (3), 13253-61 [PubMed].

Staelens J., Puimege L., Mahieu T., Pynaert G., Hochepied T., Vandenabeele A., Grooten J., Kontoyiannis D., Van Roy F., Kollias G., Libert C., 2004, "Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders", Mamm. Genome., 15, 537-543 [PubMed].

Auwerx J., Avner P., Baldock R., Ballabio A., Balling R., Barbacid M., Berns A., Bradley A., Brown S., Carmeliet P., Chambon P., Cox R., Davidson D., Davies K., Duboule D., Forejt J., Granucci F., Hastie N., de Angelis M. H., Jackson I., Kioussis D., Kollias G., Lathrop M., Lendahl U., Malumbres M., von Melchner H., Muller W., Partanen J., Ricciardi-Castagnoli P., Rigby P., Rosen B., Rosenthal N., Skarnes B., Stewart AF, Thornton J., Tocchini-Valentini G., Wagner E., Wahli W., Wurst W., 2004, "The European dimension for the mouse genome mutagenesis program", Nat. Genetics, 36, 925-7 [PubMed].

Smolen J. S., Hayer S., Schett G., Redlich K., Aringer M., Kollias G., Wagner E., Steiner G., 2004, "Autoimmunity and rheumatoid arthritis", Autoimmun. Rev., 3 Suppl 1, S23 [PubMed].

Kollias G., 2004, "Modeling the function of tumor necrosis factor in immune pathophysiology", Autoimmun. Rev., 3 Suppl 1, S24-5 [PubMed].

Xanthoulea S., Pasparakis M., Kousteni S., Brakebusch C., Wallach D., Bauer J., Lassmann H., Kollias G., 2004, "Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases", J. Exp. Med., 2;200 (3), 367-76 [PubMed].

Herrak P., Gortz B., Hayer S., Redlich K., Reiter E., Gasser J., Bergmeister H., Kollias G., Smolen J. S., Schett G., 2004, "Zoledronic acid protects against local and systemic bone loss in tumor necrosis factor-mediated arthritis", Arthritis Rheum., 50 (7), 2327-37 [PubMed].

Thwin M. M., Douni E., Aidinis V., Kollias G., Kodama K., Sato K., Satish R. L., Mahendran R., Gopalakrishnakone P., 2004, "Effect of phospholipase A2 inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study", Arthritis Res. & Ther., 6 (3), R282-94 [PubMed].

Gortz B., Hayer S., Redlich K., Zwerina J., Tohidast-Akrad M., Tuerk B., Hartmann C., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation", J. Bone Miner. Res., 19 (6), 990-8 [PubMed].

Douni E., Alexiou M., Kollias G., 2004, "Genetic engineering in the mouse: tuning TNF/TNFR expression", Methods Mol. Med., 98, 137-70 [PubMed].

Redlich K., Gortz B., Hayer S., Zwerina J., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Overexpression of tumor necrosis factor causes bilateral sacroiliitis", Arthritis Rheum., 50 (3), 1001-5 [PubMed].

Douni E., Sfikakis P. P., Haralambous S., Fernandes P., Kollias G., 2004, "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols", Arthritis Res. & Ther., 6 (1), R65-R72 [PubMed].

Redlich K., Gortz B., Hayer S., Zwerina J., Doerr N., Kostenuik P., Bergmeister H., Kollias G., Steiner G., Smolen J. S., Schett G., 2004, "Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis", Am. J. Pathol., 164 (2), 543-55 [PubMed].

Zwerina J., Hayer S., Tohidast-Akrad M., Bergmeister H., Redlich K., Feige U., Dunstan C., Kollias G., Steiner G., Smolen J., Schett G., 2004, "Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction", Arthritis Rheum., 50, 277-90 [PubMed].

2003

Schett G., Redlich K., Hayer S., Zwerina J., Bolon B., Dunstan C., Gortz B., Schulz A., Bergmeister H., Kollias G., Steiner G., Smolen J. S., 2003, "Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice", Arthritis Rheum., 48, 2042-51 [PubMed].

Sfikakis P. P., Kollias G., 2003, "Tumor necrosis factor biology in experimental and clinical arthritis", Curr. Op. Rheumatol., 15, 380-6 [PubMed].

Probst H. C., Lagnel J., Kollias G., van den Broek M., 2003, "Inducible transgenic mice reveal resting dentritic cells as potent inducers of CD8+ T cell tolerance", Immunity, 18, 713-720 [PubMed].

Aidinis V., Plows D., Haralambous S., Armaka M., Papadopoulos P., Kanaki M. Z., Koczan D., Thiessen H. J., Kollias G., 2003, "Functional analysis of an arthritogenic synovial fibroblast", Arthritis Res. & Ther., 5, 140-157 [PubMed].

Hukkanen M., Platts L. A., Haralambous S., Ainola M., Konttinen Y. T., Kollias G., Polak J. M., 2003, "Induction of Inducible Nitric Oxide Synthase, Argininosuccinate Synthase, and GTP Cyclohydrolase I in Arthritic Joints of Human Tumor Necrosis Factor-a Transgenic Mice", J. Rheumatol., 30, 652-9 [PubMed].

Ye P., Price W., Kassiotis G., Kollias G., D'Ercole A. J., 2003, "Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice", J. Neurosci. Res., 71, 721-31 [PubMed].

Akassoglou K., Douni E., Bauer J., Lassmann H., Kollias G., Probert L., 2003, "Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 100, 709-714 [PubMed].

2002

Holtmann M. H., Douni E., Schutz M., Zeller G., Mudter J., Lehr H. A., Gerspach J., Scheurich P., Galle P. R., Kollias G., Neurath M. F., 2002, "Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimenta colitis in vivo", Eur. J. Immunol., 32, 3142-51 [PubMed].

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizzaro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, "Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease", J. Exp. Med., 196, 1563-74 [PubMed].

Redlich K., Hayer S., Ricci R., David J.-P., Tohidast-Akrad M., Kollias G., Steiner G., Smolen G. S., Wagner E. F., Schett G., 2002, "Oscteoclasts are essential for TNF-α-mediated joint destruction", J. Clin. Invest., 110, 1419-1427 [PubMed].

Kollias G., Kontoyiannis D., 2002, "Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments", Cytokine Growth Factor Rev., 13, 315-321 [PubMed].

Redlich K., Hayer S., Maier A., Dunstan C. R., Tohidast-Akrad M., Lang S., Turk B., Pietschmann P., Woloszezuk W., Haralambous S., Kollias G., Steiner G., Smolen J. S., Schett G., 2002, "Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin", Arthritis Rheum., 46, 785-92 [PubMed].

Kollias G., Kontoyiannis D., Douni E., Kassiotis G., 2002, "The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies", Curr. Dir. Autoimmun., 5, 30-50 [PubMed].

Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H.-D., Holtmann H., Kollias G., Gaestel M., 2002, "MK2 targets AU-rich elements and regulates biosynthesis of Tumor Necrosis Factor and Interleukin-6 independently at different post-transcriptional levels", J. Biol. Chem., 277, 3065-3068 [PubMed].

2001

Schett G., Hayer S., Tohidast-Akrad M., Jahn Schmid B., Lang S., Turk B., Kainberger F., Kollias G., Newby A. C., Xu Q., Steiner G., Smolen J., 2001, "Adenoviral-based overexpression of TIMP-1 reduces tissue damage in the joints of TNFα-transgenic mice", Arthritis Rheum., 44, 2888-98 [PubMed].

Kassiotis G., Kranidioti K., Kollias G., 2001, "Defective CD4T cell priming and resistance to experimental autoimmune encephalomyelitis in TNF-deficient mice due to innate immune hypo-responsiveness", J. Neuroimmunol., 119, 239-47 [PubMed].

Kontoyiannis D., Kotlyarov A., Carballo E., Alexopoulou L., Blackshear P. J., Gaestel M., Davis R., Flavell R., Kollias G., 2001, "Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology", EMBO J., 20, 3760-3770 [PubMed].

Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., Vescovi A., Bagetta G., Kollias G., Meodolesi J., Volterra A., 2001, "CXCR4-activated astrocyte glytamate release via TNFα: amplification by microglia triggers neurotoxicity", Nat. Neurosci., 4, 702-10 [PubMed].

Kassiotis G., Kollias G., 2001, "TNF and receptors in organ-specific autoimmune disease: multi-layered functioning mirrored in animal models", J. Clin. Invest., 107, 1507-8 [PubMed].

Kassiotis G., Kollias G., 2001, "Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination", J. Exp. Med., 193, 427-434 [PubMed].

2000

Dumitru C. D., Ceci J. D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J. H., Patriotis C., Jenkins N. A., Copeland N. G., Kollias G., Tsichlis P. N., 2000, "TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway", Cell, 103, 1071-1083 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Fibroblast biology: Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?", Arthritis Res., 2, 342-3 [PubMed].

Biedermann T., Kneilling M., Mailhammer R., Maier K., Sander C. A., Kollias G., Kunkel S. L., Hultner L., Rocken M., 2000, "Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2", J. Exp. Med., 192, 1441-52 [PubMed].

Kontoyiannis D., Kollias G., 2000, "Accelerated autoimmunity and lupus nephritis in NZB mice with engineered heterozygous deficiency in tumor necrosis factor", Eur. J. Immunol., 30, 2038-47 [PubMed].

Schwarz E. M., Lu A. P., Goater J. J., Benz E. B., Kollias G., Rosier R. N., Puzas J. E., O'Keefe R. J., 2000, "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis", J. Orthop. Res., 18, 472-80 [PubMed].

Liefner M., Siebert H., Sachse T., Michel U., Kollias G., Bruck W., 2000, "The role of TNF-alpha during Wallerian degeneration", J. Neuroimmunol., 108, 147-52 [PubMed].

Abu-Amer Y., Erdmann J., Alexopoulou L., Kollias G., Ross F. P., Teitelbaum S. L., 2000, "Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis", J. Biol. Chem., 275, 27307-27310 [PubMed].

White D. W., Badovinac V. P., Kollias G., Harty J. T., 2000, "Cutting Edge: Antilisterial activity of CD8+T cells derived from TNF-deficient and TNF/perforin double-deficient mice", J. Immunol., 165, 5-9 [PubMed].

Pasparakis M., Kousteni S., Peschon J., Kollias G., 2000, "Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic precursors into splenic follicles", Cell. Immunol., 201, 33-41 [PubMed].

Goater J., Muller R., Kollias G., Firestein G. S., Sanz I., O'Keefe R. J., Schwarz E. M., 2000, "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis", J. Rheumatol., 27, 983-9 [PubMed].

Iyler S., Kontoyiannis D., Chevrier D., Woo J., Mori N., Cornejo M., Kollias G., Buelow R., 2000, "Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide", J. Biol. Chem., 275, 17051-7 [PubMed].

Mabbott N. A., Williams A., Farquhar C. F., Pasparakis M., Kollias G., Bruce M. E., 2000, "Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie", J. Virol., 74, 3338-44 [PubMed].

1999

Akassoglou K., Bauer J., Kassiotis G., Lassmann H., Kollias G., Probert L., 1999, "Transgenic models of TNF induced demyelination", Adv. Exp. Med. Biol., 468, 245-259 [PubMed].

Van den Berg W. B., Joosten L. A., Kollias G., and van De Loo F. A., 1999, "Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction", Ann. Rheum. Dis., 58 Suppl 1, I40-8 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Ann. Rheum. Dis., 58 Suppl 1, I32-9 [PubMed].

Kollias G., Douni E., Kassiotis G., Kontoyiannis D., 1999, "On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease", Immunol. Rev., 169, 175-194 [PubMed].

Glosli H., Veiby O. P., Fjerdingstad H., Mehlum A., Probert L., Kollias G., Gjernes E., Prydz H., 1999, "Effects of hTNFalpha expression in T cells on haematopoiesis in transgenic mice", Eur. J. Haematol., 63, 50-60 [PubMed].

Moore R. J., Owens D. M., Stamp G., Arnott C., Burke F., East N., Holdsworth H., Turner L., Rollins B., Pasparakis M., Kollias G., Balkwill F., 1999, "Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis", Nat. Med., 5, 828-831 [PubMed].

Zhang Y., Pasparakis M., Kollias G., Simons M., 1999, "Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha", J. Biol. Chem., 274, 14786-14790 [PubMed].

Kontoyiannis D., Pasparakis M., Pizarro T. T., Cominelli F., Kollias G., 1999, "Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies", Immunity, 10, 387-398 [PubMed].

Kassiotis G., Bauer J., Akassoglou K., Lassmann H., Kollias G., Probert L., 1999, "A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice", Eur. J. Immunol., 29, 912-917 [PubMed].

Kassiotis G., Bauer J., Akassoglou K., Lassmann H., Kollias G., Probert L., 1999, "TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis", Eur. J. Immunol., 29:1, 774-780 [PubMed].

Neurath M. F., Hildner K., Becker C., Schlaak J. F., Barbulescu K., Germann T., Schmitt E., Schirmacher P., Haralambous S., Pasparakis M., Meyer Z. B. K., Kollias G., Marker-Hermann E., 1999, "Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression", Clin. Exp. Immunol., 115, 42-55 [PubMed].

Plows D., Kontogeorgos G., Kollias G., 1999, "Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen", J. Immunol., 162, 1018-1023 [PubMed].

1998

Adorini L., Bonneville M., Kollias G., 1998, "Pathogenic and protective T-cell responses in autoimmune diseases", Res. Immunol., 149, 873-875 [PubMed].

Tselios T., Probert L., Kollias G., Matsoukas E., Roumelioti P., Alexopoulos K., Moore G. J., Matsoukas J., 1998, "Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on myelin basic protein (MBP)", Amino. Acids., 14, 333-341 [PubMed].

Maurer M., Echtenacher B., Hultner L., Kollias G., Mannel D. N., Langley K. E., Galli S. J., 1998, "The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells", J. Exp. Med., 188, 2343-2348 [PubMed].

Douni E., Kollias G., 1998, "A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF- R", J. Exp. Med., 188, 1343-1352 [PubMed].

Akassoglou K., Bauer J., Kassiotis G., Pasparakis M., Lassmann H., Kollias G., Probert L., 1998, "Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy", Am. J. Pathol., 153, 801-813 [PubMed].

Alexopoulou L., Pasparakis M., Kollias G., 1998, "Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function", J. Exp. Med., 188, 745-754 [PubMed].

Fiore M., Alleva E., Probert L., Kollias G., Angelucci F., Aloe L., 1998, "Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha", Physiol. Behav., 63, 571-576 [PubMed].

Bessis N., Chiocchia G., Kollias G., Minty A., Fournier C., Fradelizi D., Boissier M. C., 1998, "Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-alpha)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13", Clin. Exp. Immunol., 111, 391-396 [PubMed].

Alonzi T., Fattori E., Lazzaro D., Costa P., Probert L., Kollias G., De Benedetti F., Poli V., Ciliberto G., 1998, "Interleukin 6 is required for the development of collagen-induced arthritis", J. Exp. Med., 187, 461-468 [PubMed].

1997

Kusters S., Tiegs G., Alexopoulou L., Pasparakis M., Douni E., Kunstle G., Bluethmann H., Wendel A., Pfizenmaier K., Kollias G., Grell M., 1997, "In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis", Eur. J. Immunol., 27, 2870-2875 [PubMed].

Alexopoulou L., Pasparakis M., Kollias G., 1997, "A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling", Eur. J. Immunol., 27, 2588-2592 [PubMed].

Plumier J. C., Krueger A. M., Currie R. W., Kontoyiannis D., Kollias G., Pagoulatos G. N., 1997, "Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury", Cell Stress Chaperones, 2, 162-167 [PubMed].

Butler D. M., Malfait A. M., Mason L. J., Warden P. J., Kollias G., Maini R. N., Feldmann M., Brennan F. M., 1997, "DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition", J. Immunol., 159, 2867-2876 [PubMed].

Ventre J., Doebber T., Wu M., MacNaul K., Stevens K., Pasparakis M., Kollias G., Moller D. E., 1997, "Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice", Diabetes, 46, 1526-1531 [PubMed].

Neurath M. F., Fuss I., Pasparakis M., Alexopoulou L., Haralambous S., Meyer Z. B. K., Strober W., Kollias G., 1997, "Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice", Eur. J. Immunol., 27, 1743-1750 [PubMed].

Pasparakis M., Alexopoulou L., Grell M., Pfizenmaier K., Bluethmann H., Kollias G., 1997, "Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor", Proc. Natl. Acad. Sci. U.S.A., 94, 6319-6323 [PubMed].

Cope A. P., Liblau R. S., Yang X. D., Congia M., Laudanna C., Schreiber R. D., Probert L., Kollias G., McDevitt H. O., 1997, "Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling", J. Exp. Med., 185, 1573-1584 [PubMed].

Probert L., Akassoglou K., Kassiotis G., Pasparakis M., Alexopoulou L., Kollias G., 1997, "TNF-alpha transgenic and knockout models of CNS inflammation and degeneration", J. Neuroimmunol., 72, 137-141 [PubMed].

Akassoglou K., Probert L., Kontogeorgos G., Kollias G., 1997, "Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice", J. Immunol., 158, 438-445 [PubMed].

1996

Pasparakis M., Alexopoulou L., Douni E., Kollias G., 1996, "Tumour necrosis factors in immune regulation: everything that's interesting is...new!", Cytokine Growth Factor Rev., 7, 223-229 [PubMed].

Pasparakis M., Alexopoulou L., Episkopou V., Kollias G., 1996, "Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response", J. Exp. Med., 184, 1397-1411 [PubMed].

Fiore M., Probert L., Kollias G., Akassoglou K., Alleva E., Aloe L., 1996, "Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain", Brain Behav. Immun., 10, 126-138 [PubMed].

Georgopoulos S., Plows D., Kollias G., 1996, "Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice", J. Inflamm., 46, 86-97 [PubMed].

Probert L., Akassoglou K., Alexopoulou L., Douni E., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Kollias G., 1996, "Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice", J. Leukoc. Biol., 59, 518-525 [PubMed].

1995

Douni E., Akassoglou K., Alexopoulou L., Georgopoulos S., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Probert L., Kollias G., 1995, "Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis", J. Inflamm., 47, 27-38 [PubMed].

Grell M., Douni E., Wajant H., Lohden M., Clauss M., Maxeiner B., Georgopoulos S., Lesslauer W., Kollias G., Pfizenmaier K., 1995, "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor", Cell, 83, 793-802 [PubMed].

Plumier J. C., Ross B. M., Currie R. W., Angelidis C. E., Kazlaris H., Kollias G., Pagoulatos G. N., 1995, "Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery", J. Clin. Invest., 95, 1854-1860 [PubMed].

Probert L., Plows D., Kontogeorgos G., Kollias G., 1995, "The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice", Eur. J. Immunol., 25, 1794-1797 [PubMed].

Aloe L., Probert L., Kollias G., Micera A., Tirassa P., 1995, "Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice", Rheumatol. Int., 14, 249-252 [PubMed].

Siegel S. A., Shealy D. J., Nakada M. T., Le J., Woulfe D. S., Probert L., Kollias G., Ghrayeb J., Vilcek J., Daddona P. E., 1995, "The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo", Cytokine, 7, 15-25 [PubMed].

Probert L., Akassoglou K., Pasparakis M., Kontogeorgos G., Kollias G., 1995, "Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha", Proc. Natl. Acad. Sci. U.S.A., 92, 11294-11298 [PubMed].

1994

Taverne J., Sheikh N., de Souza J. B., Playfair J. H., Probert L., Kollias G., 1994, "Anaemia and resistance to malaria in transgenic mice expressing human tumour necrosis factor", Immunology, 82, 397-403 [PubMed].

1993

Grigoreas C., Pappas D., Galatas I. D., Kollias G., Papadimos S., Papadakis P., 1993, "Serum total IgE levels in a representative sample of a Greek population. I. Correlation with age, sex, and skin reactivity to common aeroallergens", Allergy, 48 (3), 142-146 [PubMed].

Probert L., Keffer J., Corbella P., Cazlaris H., Patsavoudi E., Stephens S., Kaslaris E., Kioussis D., Kollias G., 1993, "Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell- targeted human tumor necrosis factor transgenes", J. Immunol., 151, 1894-1906 [PubMed].

Kollias G., 1993, "Tumour necrosis factor: a specific trigger in arthritis", Res. Immunol., 144, 342-347 [PubMed].

Aloe L., Probert L., Kollias G., Bracci-Laudiero L., Spillantini M. G., Levi-Montalcini R., 1993, "The synovium of transgenic arthritic mice expressing human tumor necrosis factor contains a high level of nerve growth factor", Growth Factors, 9, 149-155 [PubMed].

Aloe L., Probert L., Kollias G., Bracci-Laudiero L., Micera A., Mollinari C., Levi-Montalcini R., 1993, "Level of nerve growth factor and distribution of mast cells in the synovium of tumour necrosis factor transgenic arthritic mice", Int. J. Tissue React., 15, 139-143 [PubMed].

1991

Keffer J., Probert L., Cazlaris H., Georgopoulos S., Kaslaris E., Kioussis D., Kollias G., 1991, "Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis", EMBO J., 10, 4025-4031 [PubMed].

Dillon N., Kollias G., Grosveld F., Williams J. G., 1991, "Expression of adult and tadpole specific globin genes from Xenopus laevis in transgenic mice", Nucleic. Acids. Res., 19, 6227-6230 [PubMed].

1988

Grosveld F., Kollias G., 1988, "Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities", Cell, 54, 920 [PubMed].

1987

Grosveld F., van Assendelft G. B., Greaves D. R., Kollias G., 1987, "Position-independent, high-level expression of the human beta-globin gene in transgenic mice", Cell, 51, 975-985 [PubMed].

Grosveld F., Antoniou M., van Assendelft G. B., de Boer E., Hurst J., Kollias G., MacFarlane F., Wrighton N., 1987, "The regulation of expression of human beta-globin genes", Prog. Clin. Biol. Res., 251, 133-144 [PubMed].

Kollias G., Hurst J., deBoer E., Grosveld F., 1987, "The human beta-globin gene contains a downstream developmental specific enhancer", Nucleic. Acids. Res., 15, 5739-5747 [PubMed].

Kollias G., Evans D. J., Ritter M., Beech J., Morris R., Grosveld F., 1987, "Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities", Cell, 51, 21-31 [PubMed].

Kollias G., Spanopoulou E., Grosveld F., Ritter M., Beech J., Morris R., 1987, "Differential regulation of a Thy-1 gene in transgenic mice", Proc. Natl. Acad. Sci. U.S.A., 84, 1492-1496 [PubMed].

1986

Kollias G., Wrighton N., Hurst J., Grosveld F., 1986, "Regulated expression of human A gamma-, beta-, and hybrid gamma beta- globin genes in transgenic mice: manipulation of the developmental expression patterns", Cell, 46, 89-94 [PubMed].

Kolsto A. B., Kollias G., Giguere V., Isobe K. I., Prydz H., Grosveld F., 1986, "The maintenance of methylation-free islands in transgenic mice", Nucleic. Acids. Res., 14, 9667-9678 [PubMed].

Isobe K., Kollias G., Kolsto A. B., Grosveld F., 1986, "T cell independent Thy-1 allo-antibody response with the use of transgenic mice", J. Immunol., 137, 2089-2092 [PubMed].

1985

Kollias G., Sekeris C. E., Grosveld F. G., 1985, "Alpha-amanitin insensitive transcription of the human epsilon-globin gene", Nucleic. Acids. Res., 13, 7993-8005 [PubMed].